8PXX: WW domain tandem of PRPF40A

Structure of the WW domain tandem of PRPF40A in complex with SF1. Determined by solution NMR. Released 3 Apr 2024.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 976
Mol. weight: 13.87 kDa
Released: 3 Apr 2024

Explore 8PXX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8PXX contains 8 α-helices and 6 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	139-141	3
α-helix	142-144	3
β-strand	146-150	5	1
β-strand	156-160	5	1
β-strand	166-167	2	1
α-helix	170-171	2
α-helix	177-183	7
β-strand	187-191	5	2
β-strand	197-201	5	2
β-strand	207-208	2	2
α-helix	211-212	2
α-helix	213-219	7

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	575-578	4
α-helix	586-590	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Pre-mRNA-processing factor 40 homolog A	A	protein	99	Homo sapiens	O75400 (AlphaFold model)
Splicing factor 1	B	protein	27	Homo sapiens	Q15637 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8PXX_1 Pre-mRNA-processing factor 40 homolog A (chains A)
GAMGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKP
YYYNSQTKESRWAKPKELEDLEGYQNTIVAGSLITKSNL

Sequence of entity 2 (B), FASTA

>8PXX_2 Splicing factor 1 (chains B)
GAMSGSPPLPPGAPPPPPPPPPSGSGN

Primary citation

Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs. Martinez-Lumbreras, S., Trager, L.K., Mulorz, M.M. et al. Nat Commun (2024) 15:3888-3888. DOI 10.1038/s41467-024-48004-x · PubMed

Other PDB entries of the same protein (UniProt O75400 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1UZC The structure of an ff domain from human HYPA/FBP11
1YWI Structure of the FBP11WW1 domain complexed to the peptide APPTPPPLPP
1YWJ Structure of the FBP11WW1 domain
1ZR7 Solution structure of the first WW domain of FBP11
2CQN Solution structure of the FF domain of human Formin-binding protein 3
2DYF Solution structure of the first WW domain of FBP11 / HYPA (FBP11 WW1) complexed with a…
2KZG A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution
2L5F Solution structure of the tandem WW domains from HYPA/FBP11
2L9V NMR structure of the FF domain L24A mutant's folding transition state
2LKS Ff11-60
8PXW Structure of the WW domain tandem of PRPF40A

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