8VRD: Gamma-tubulin complex component 3
Rigid body fitted model for free recombinant gamma tubulin ring complex. Determined by electron microscopy at 7.0 Å resolution. Released 27 Mar 2024.
- Method
- Electron microscopy
- Resolution
- 7.0 Å
- Organism
- Homo sapiens
- Chains
- 34
- Atoms
- 67,053
- Mol. weight
- 2807.02 kDa
- Released
- 27 Mar 2024
Explore 8VRD in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8VRD contains 671 α-helices and 321 β-strands across 34 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains a, b, c, d, e, f, g, h, m and n: 15 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-9 | 6 | 34 |
| α-helix | 11-28 | 18 | |
| β-strand | 31 | 1 | 35 |
| β-strand | 37 | 1 | 35 |
| β-strand | 52-53 | 2 | 36 |
| β-strand | 61-62 | 2 | 36 |
| β-strand | 64-66 | 3 | 34 |
| α-helix | 73-79 | 7 | |
| α-helix | 83-85 | 3 | |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 132-138 | 7 | 34 |
| β-strand | 140 | 1 | 37 |
| α-helix | 145-160 | 16 | |
| β-strand | 165 | 1 | 34 |
| β-strand | 168 | 1 | 34 |
| β-strand | 171-172 | 2 | 37 |
| α-helix | 184-195 | 12 | |
| β-strand | 205-206 | 2 | 37 |
| α-helix | 207-217 | 11 | |
| α-helix | 225-239 | 15 | |
| α-helix | 253-260 | 8 | |
| β-strand | 270-273 | 4 | 38 |
| α-helix | 290-297 | 8 | |
| β-strand | 317-324 | 8 | 38 |
| α-helix | 333-343 | 11 | |
| β-strand | 348 | 1 | 38 |
| β-strand | 356-360 | 5 | 38 |
| β-strand | 376-381 | 6 | 38 |
| α-helix | 382-384 | 3 | |
| α-helix | 385-399 | 15 | |
| α-helix | 420-436 | 17 | |
Chains A, C, E and G: 31 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 233-235 | 3 | |
| α-helix | 238-252 | 15 | |
| β-strand | 262-263 | 2 | 26 |
| β-strand | 274-275 | 2 | 26 |
| α-helix | 282-288 | 7 | |
| α-helix | 292-294 | 3 | |
| α-helix | 302-305 | 4 | |
| α-helix | 319-323 | 5 | |
| α-helix | 326-343 | 18 | |
| α-helix | 349-355 | 7 | |
| α-helix | 357-369 | 13 | |
| α-helix | 382-389 | 8 | |
| α-helix | 400-410 | 11 | |
| α-helix | 415-422 | 8 | |
| β-strand | 437-439 | 3 | 27 |
| β-strand | 460-462 | 3 | 27 |
| α-helix | 472-474 | 3 | |
| α-helix | 475-489 | 15 | |
| α-helix | 513-532 | 20 | |
| α-helix | 538-545 | 8 | |
| α-helix | 570 | 1 | |
| α-helix | 576-589 | 14 | |
| α-helix | 591-593 | 3 | |
| α-helix | 598-600 | 3 | |
| β-strand | 601-603 | 3 | 28 |
| β-strand | 646-648 | 3 | 28 |
| α-helix | 652-655 | 4 | |
| α-helix | 660-662 | 3 | |
| α-helix | 664-682 | 19 | |
| α-helix | 686-690 | 5 | |
| α-helix | 708-725 | 18 | |
| α-helix | 726-730 | 5 | |
| α-helix | 731-740 | 10 | |
| α-helix | 747-764 | 18 | |
| α-helix | 775-790 | 16 | |
| α-helix | 850-867 | 18 | |
| α-helix | 884-887 | 4 | |
Chains B, D, F, H and N: 29 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 247-257 | 11 | |
| β-strand | 266 | 1 | 42 |
| β-strand | 277 | 1 | 42 |
| α-helix | 285-310 | 26 | |
| α-helix | 320-325 | 6 | |
| α-helix | 330-344 | 15 | |
| α-helix | 364-370 | 7 | |
| α-helix | 377-387 | 11 | |
| α-helix | 394-397 | 4 | |
| α-helix | 415-430 | 16 | |
| β-strand | 448-450 | 3 | 43 |
| β-strand | 464-466 | 3 | 43 |
| α-helix | 480-495 | 16 | |
| α-helix | 529-551 | 23 | |
| α-helix | 555-564 | 10 | |
| α-helix | 572-580 | 9 | |
| α-helix | 582-585 | 4 | |
| α-helix | 589-591 | 3 | |
| α-helix | 594-607 | 14 | |
| α-helix | 609-611 | 3 | |
| α-helix | 615-620 | 6 | |
| β-strand | 623-625 | 3 | 44 |
| β-strand | 638-640 | 3 | 44 |
| α-helix | 649-652 | 4 | |
| α-helix | 657-675 | 19 | |
| α-helix | 677-687 | 11 | |
| α-helix | 698-722 | 25 | |
| α-helix | 723-727 | 5 | |
| α-helix | 732-735 | 4 | |
| α-helix | 745-761 | 17 | |
| α-helix | 769-808 | 40 | |
| α-helix | 826-838 | 13 | |
| α-helix | 840-865 | 26 | |
| α-helix | 874-880 | 7 | |
| α-helix | 882-884 | 3 | |
Chain i: 15 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-9 | 6 | 103 |
| α-helix | 11-28 | 18 | |
| β-strand | 31-32 | 2 | 104 |
| β-strand | 36-37 | 2 | 104 |
| β-strand | 52-53 | 2 | 105 |
| β-strand | 61-62 | 2 | 105 |
| β-strand | 64-66 | 3 | 103 |
| α-helix | 73-79 | 7 | |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 132-140 | 9 | 103 |
| α-helix | 145-160 | 16 | |
| β-strand | 165 | 1 | 103 |
| β-strand | 168-172 | 5 | 103 |
| α-helix | 184-195 | 12 | |
| β-strand | 204-206 | 3 | 103 |
| α-helix | 207-217 | 11 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 270-273 | 4 | 106 |
| α-helix | 290-297 | 8 | |
| β-strand | 317-324 | 8 | 106 |
| α-helix | 333-343 | 11 | |
| β-strand | 348 | 1 | 106 |
| β-strand | 356-360 | 5 | 106 |
| β-strand | 376-381 | 6 | 106 |
| α-helix | 382-384 | 3 | |
| α-helix | 385-399 | 15 | |
| α-helix | 420-438 | 19 | |
Chains I and K: 32 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-8 | 7 | |
| β-strand | 17-18 | 2 | 107 |
| β-strand | 26-27 | 2 | 107 |
| α-helix | 38-61 | 24 | |
| α-helix | 84-96 | 13 | |
| α-helix | 98-113 | 16 | |
| α-helix | 119-126 | 8 | |
| α-helix | 129-131 | 3 | |
| α-helix | 133-136 | 4 | |
| α-helix | 138-144 | 7 | |
| α-helix | 150-152 | 3 | |
| α-helix | 153-156 | 4 | |
| α-helix | 166-169 | 4 | |
| α-helix | 172-193 | 22 | |
| α-helix | 270-284 | 15 | |
| α-helix | 302-316 | 15 | |
| α-helix | 322-341 | 20 | |
| α-helix | 342-347 | 6 | |
| α-helix | 350-360 | 11 | |
| α-helix | 366-375 | 10 | |
| α-helix | 378-381 | 4 | |
| α-helix | 383-384 | 2 | |
| α-helix | 388-402 | 15 | |
| β-strand | 414-418 | 5 | 108 |
| α-helix | 448-451 | 4 | |
| β-strand | 452-456 | 5 | 108 |
| α-helix | 461-463 | 3 | |
| α-helix | 470-498 | 29 | |
| α-helix | 511-513 | 3 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-547 | 12 | |
| α-helix | 554-570 | 17 | |
| α-helix | 576-597 | 22 | |
| α-helix | 607-629 | 23 | |
| α-helix | 641-647 | 7 | |
| α-helix | 652-655 | 4 | |
Chain j: 15 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-9 | 6 | 2 |
| α-helix | 11-28 | 18 | |
| β-strand | 31 | 1 | 3 |
| β-strand | 37 | 1 | 3 |
| β-strand | 53 | 1 | 4 |
| β-strand | 61 | 1 | 4 |
| β-strand | 64-66 | 3 | 2 |
| α-helix | 73-79 | 7 | |
| α-helix | 104-113 | 10 | |
| α-helix | 115-126 | 12 | |
| β-strand | 132-138 | 7 | 2 |
| β-strand | 140 | 1 | 5 |
| α-helix | 145-160 | 16 | |
| β-strand | 167-168 | 2 | 2 |
| β-strand | 171 | 1 | 5 |
| β-strand | 172 | 1 | 6 |
| α-helix | 184-195 | 12 | |
| β-strand | 206 | 1 | 6 |
| α-helix | 207-216 | 10 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-257 | 5 | |
| β-strand | 270-272 | 3 | 7 |
| α-helix | 290-297 | 8 | |
| β-strand | 303 | 1 | 7 |
| β-strand | 317-324 | 8 | 7 |
| α-helix | 333-343 | 11 | |
| β-strand | 356-360 | 5 | 7 |
| β-strand | 375-381 | 7 | 7 |
| α-helix | 382-384 | 3 | |
| α-helix | 385-399 | 15 | |
| α-helix | 420-438 | 19 | |
Chain J: 27 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 268-279 | 12 | |
| α-helix | 305-307 | 3 | |
| α-helix | 309-335 | 27 | |
| α-helix | 361-387 | 27 | |
| α-helix | 395-401 | 7 | |
| α-helix | 403-415 | 13 | |
| α-helix | 416-419 | 4 | |
| α-helix | 429-446 | 18 | |
| α-helix | 457-481 | 25 | |
| α-helix | 553-570 | 18 | |
| α-helix | 639-647 | 9 | |
| α-helix | 688-690 | 3 | |
| α-helix | 692-711 | 20 | |
| α-helix | 716-723 | 8 | |
| α-helix | 735-743 | 9 | |
| α-helix | 757-763 | 7 | |
| α-helix | 807-810 | 4 | |
| α-helix | 815-840 | 26 | |
| α-helix | 882-899 | 18 | |
| α-helix | 900-905 | 6 | |
| α-helix | 908-917 | 10 | |
| α-helix | 923-940 | 18 | |
| α-helix | 947-951 | 5 | |
| α-helix | 952-966 | 15 | |
| α-helix | 981-998 | 18 | |
| α-helix | 1008-1010 | 3 | |
| α-helix | 1011-1014 | 4 | |
Chain k: 17 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-9 | 5 | 8 |
| α-helix | 11-28 | 18 | |
| β-strand | 31 | 1 | 9 |
| β-strand | 37 | 1 | 9 |
| β-strand | 52-53 | 2 | 10 |
| β-strand | 61-62 | 2 | 10 |
| β-strand | 64-66 | 3 | 8 |
| α-helix | 73-79 | 7 | |
| α-helix | 83-85 | 3 | |
| α-helix | 104-113 | 10 | |
| α-helix | 115-128 | 14 | |
| β-strand | 134-138 | 5 | 8 |
| α-helix | 144-145 | 2 | |
| α-helix | 146-150 | 5 | |
| α-helix | 151-160 | 10 | |
| β-strand | 165-168 | 4 | 8 |
| α-helix | 184-195 | 12 | |
| α-helix | 207-216 | 10 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 254-257 | 4 | |
| β-strand | 270-273 | 4 | 11 |
| α-helix | 290-297 | 8 | |
| β-strand | 303 | 1 | 11 |
| β-strand | 317-324 | 8 | 11 |
| α-helix | 333-343 | 11 | |
| β-strand | 356-360 | 5 | 11 |
| β-strand | 376-381 | 6 | 11 |
| α-helix | 384-399 | 16 | |
| α-helix | 420-436 | 17 | |
9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Gamma-tubulin complex component 3 | B, D, F, H, N, O | protein | 907 | Homo sapiens | Q96CW5 (AlphaFold model) |
| TUBGCP6 protein | L, P, T | protein | 1811 | Homo sapiens | Q96RT7 (AlphaFold model) |
| Mitotic-spindle organizing protein 1 | Q, R | protein | 82 | Homo sapiens | Q08AG7 (AlphaFold model) |
| Actin, cytoplasmic 1 | S | protein | 375 | Homo sapiens | P60709 (AlphaFold model) |
| Isoform 3 of Gamma-tubulin complex component 2 | A, C, E, G, M | protein | 930 | Homo sapiens | Q9BSJ2 |
| Tubulin gamma-1 chain | a, b, c, d, e, f, g, h, i, j, k, l, m, n | protein | 457 | Homo sapiens | P23258 |
| Isoform 2 of Gamma-tubulin complex component 4 | I, K | protein | 666 | Homo sapiens | Q9UGJ1 |
| Gamma-tubulin complex component 5 | J | protein | 1024 | Homo sapiens | Q96RT8 |
Sequence of entity 1 (B, D, F, H, N, O), FASTA
>8VRD_1 Gamma-tubulin complex component 3 (chains B, D, F, H, N, O)
MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQ
ALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSL
LPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTG
GTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWL
HNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLES
SLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILS
LVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQS
RKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFE
TSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGI
LETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHY
LRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQY
YITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFD
QIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESI
PKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTR
GRRSSHT
Sequence of entity 2 (L, P, T), FASTA
>8VRD_2 TUBGCP6 protein (chains L, P, T)
MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD
MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS
GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ
VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD
LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV
GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL
IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD
SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG
AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV
YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK
TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE
KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR
QAARQEELDDDFSYARELRDRERRLKSLEEELERKASKLSAEAARREQKALWRIQRHRLE
SARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSA
EQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEP
SVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPG
PLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQ
VSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASI
SLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNASIRVGENV
SDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGESVSDMAPT
RPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVVSTRPRWNT
HVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSAVLDCGPRLPVEVGPS
LSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDLSPNWPLNS
QEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHLLR
PVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVNKAAVDYFF
VELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQC
SLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCLSKYSGVF
SFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVIQGYIANQI
LHVTWCEFRARLATVGDLEEIQRAHAEYLHEAVFRGLLTEKAAPVMNVIHSIFSLVLKFR
SQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLL
RINFNNYYQDA
Sequence of entity 3 (Q, R), FASTA
>8VRD_3 Mitotic-spindle organizing protein 1 (chains Q, R)
MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEAL
SSVIKELRKATEALKAAENMTS
Sequence of entity 4 (S), FASTA
>8VRD_4 Actin, cytoplasmic 1 (chains S)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Sequence of entity 5 (A, C, E, G, M), FASTA
>8VRD_5 Isoform 3 of Gamma-tubulin complex component 2 (chains A, C, E, G, M)
MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTP
EDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQYLQQNAKERAELAAAAVGSSTTSI
NVPAAASKISMQELEELRKQLGSVATGSTLQQSLELKRKMLRDKQNKKNSGQHLPIFPAW
VYERPALIGDFLIGAGISTDTALPIVLLGWSLALSPRLKCSGVISAHCGLHLPGTLPLAS
QESAVVEDLLYVLVGVDGRYVSAQPLAGRQSRTFLVDPNLDLSIRELVHRILPVAASYSA
VTRFIEEKSSFEYGQVNHALAAAMRTLVKEHLILVSQLEQLHRQGLLSLQKLWFYIQPAM
RTMDILASLATSVDKGECLGGSTLSLLHDRSFSYTGDSQAQELCLYLTKAASAPYFEVLE
KWIYRGIIHDPYSEFMVEEHELRKERIQEDYNDKYWDQRYTIVQQQIPSFLQKMADKILS
TGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELVAH
LRSIKRYFLMDQGDFFVHFMDLAEEELRKPVEDITPPRLEALLELALRMSTANTDPFKDD
LKIDLMPHDLITQLLRVLAIETKQEKAMAHADPTELALSGLEAFSFDYIVKWPLSLIINR
KALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQN
IQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTGFLDTCLKDCMLTNPELLKVFSKLM
SVCVMFTNCMQKFTQSMKLDGELGGQTLEHSTVLGLPAGAEERARKELARKHLAEHADTV
QLVSGFEATINKFDKNFSAHLLDLLARLSIYSTSDCEHGMASVISRLDFNGFYTERLERL
SAERSQKATPQVPVLRGPPAPAPRVAVTAQ
Sequence of entity 6 (a, b, c, d, e, f, g, h, i, j, k, l, m, n), FASTA
>8VRD_6 Tubulin gamma-1 chain (chains a, b, c, d, e, f, g, h, i, j, k, l, m, n)
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE
MDTSREIVQQLIDEYHAATRPDYISWGTQEQENLYFQ
Sequence of entity 7 (I, K), FASTA
>8VRD_7 Isoform 2 of Gamma-tubulin complex component 4 (chains I, K)
MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIE
QYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSIS
HVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCH
GVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQD
LRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSIL
KNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDF
YLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEY
HGKEHKDATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFKY
LLSVRRVQAELQHCWALQMQRKHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQF
SQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQNL
GPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGGT
LGSFGM
Sequence of entity 8 (J), FASTA
>8VRD_8 Gamma-tubulin complex component 5 (chains J)
MARHGPPWSRLDAQQERDVRELVRGVAGLQDEADPNFQLALNFAWSNFRFHRFLDVNSHK
IEKTIEGIYEKFVIHSDLSKAASWKRLTEEFLNAPLPSIKEIKTDAHYSILSLLLCLSDS
PSNSSYVETPRNKEVEKKDDFDWGKYLMEDEEMDIGPYMDTPNWSEESEEENDQQPLSRE
DSGIQVDRTPLEEQDQNGKLDPCISWKDEPDDRSWLEHHVVHQYWTARPSQFPHSLHLHS
NLAAVWDQHLYSSDPLYVPDDRVLVTETQVIRETLWLLSGVKKLFIFQLIDGKVTVRNNI
IVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEAPFRT
YQAFMWALYKYFISFKEELAEIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGV
AEVPPDTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWI
VHGHLWDGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQG
PSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCAESTTCQAGARDAERKSLYTLFLESV
QSRLRHGEDSTPQVLTEQQATKENLMKMQSIAESHLELDDVHDPLLAINFARMYLEQSDF
HEKFAGGDVCVDRSSESVTCQTFELTLRSCLYPHIDKQYLDCCGNLMQTLKKDYRLVEYL
QAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSIS
FENVDTAKKKLPVHILDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLDV
LLFGELVSTAEKPRLKEGLIHEQDTVAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHNY
IMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLNL
ALMFADGWQAGLGTWRMESIEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSLMAG
MEQS
Primary citation
Structure of the gamma-tubulin ring complex-capped microtubule. Aher, A., Urnavicius, L., Xue, A. et al. Nat Struct Mol Biol (2024) 31:1124-1133. DOI 10.1038/s41594-024-01264-z · PubMed
Other PDB entries of the same protein (UniProt Q96CW5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8RX1 3.57 Å, CryoEM structure of the gTuRC-CM1dim complex
- 6X0U 3.6 Å, Structure of MZT1/GCP3-NHD and MZT1/GCP6-NHD in the gamma-TuRC lumenal bridge
- 9SMX 3.67 Å, CM1-activated gTuRC in complex with nascent alpha-E254D mutant microtubules
- 8Q62 3.72 Å, Early closed conformation of the g-tubulin ring complex
- 6V6B 3.8 Å, Structures of GCP2 and GCP3 in the native human gamma-tubulin ring complex
- 7AS4 4.13 Å, Recombinant human gTuRC
- 6V6S 4.3 Å, Structure of the native human gamma-tubulin ring complex
- 9QVN 4.7 Å, Cryo-EM reconstruction of the NEDD1 anchor protein bound to the gamma-tubulin ring complex
- 7QJ0 5.32 Å, Structure of recombinant human gamma-Tubulin Ring Complex 6-spoked assembly intermediate…
- 9QVM 6.8 Å, Cryo-EM reconstruction of the NEDD1 anchor protein and CDK5RAP2 bound to the…
- 7QJ1 7.0 Å, Structure of the recombinant human gamma-Tubulin Ring Complex 6-spoked assembly…
- 7QJD 7.1 Å, Structure of recombinant human gamma-Tubulin Ring Complex without actin
Browse structure collections
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