8XGC: DNA replication licensing factor MCM2

Name: PDB 8XGC: Structure of yeast replisome associated with FACT and histone hexamer, Composite map
Published: 2024-02-14
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: replication

Structure of yeast replisome associated with FACT and histone hexamer, Composite map. Determined by electron microscopy at 3.7 Å resolution. Released 14 Feb 2024.

Method: Electron microscopy
Resolution: 3.7 Å
Organism: Saccharomyces cerevisiae
Chains: 29
Atoms: 82,765
Mol. weight: 2034.41 kDa
Ligands: ZN, ADP
Released: 14 Feb 2024

Explore 8XGC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8XGC contains 450 α-helices and 439 β-strands across 27 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 41 helices, 35 β-strands

Element	Residues	Length	Sheet
α-helix	55-57	3
α-helix	60-67	8
β-strand	71-72	2	1
α-helix	77-79	3
α-helix	106-124	19
β-strand	142	1	2
β-strand	148	1	2
α-helix	149-151	3
α-helix	183-187	5
α-helix	194-199	6
α-helix	201-216	16
β-strand	219	1	3
β-strand	225	1	3
α-helix	226-236	11
β-strand	241-245	5	4
α-helix	246-251	6
α-helix	254-262	9
α-helix	264-282	19
α-helix	286-288	3
β-strand	294-298	5	4
β-strand	303	1	5
α-helix	311-313	3
β-strand	316-327	12	5
α-helix	328-330	3
β-strand	331-334	4	5
β-strand	336-337	2	6
β-strand	339-341	3	7
α-helix	346	1
β-strand	347	1	7
α-helix	348-350	3
β-strand	351-352	2	6
β-strand	373-375	3	7
β-strand	382-391	10	5
α-helix	392-393	2
α-helix	398	1
β-strand	405-411	7	5
α-helix	412-414	3
β-strand	423-433	11	5
α-helix	436-442	7
β-strand	446	1	8
β-strand	448-458	11	5
α-helix	478-488	11
α-helix	493-500	8
α-helix	509-520	12
β-strand	525-527	3	9
β-strand	531-533	3	9
β-strand	539-543	5	10
α-helix	549-559	11
β-strand	563-567	5	10
α-helix	568-570	3
β-strand	571	1	11
β-strand	578-582	5	12
β-strand	589-593	5	12
α-helix	597-599	3
β-strand	603-607	5	10
α-helix	614-617	4
α-helix	621-625	5
β-strand	628-633	6	13
β-strand	636-641	6	13
β-strand	645-650	6	10
α-helix	653-655	3
α-helix	663-666	4
α-helix	671-675	5
β-strand	679-683	5	10
β-strand	686	1	14
α-helix	691-705	15
α-helix	740-753	14
α-helix	760-772	13
β-strand	777	1	15
α-helix	785-796	12
α-helix	803-804	2
α-helix	807-823	17
β-strand	828	1	15
α-helix	831-848	18
α-helix	854-860	7
α-helix	862-865	4

Chain 3: 28 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	37-53	17
β-strand	95-99	5	16
α-helix	100-104	5
α-helix	108-116	9
α-helix	122-136	15
α-helix	144-148	5
β-strand	154-158	5	16
α-helix	162-164	3
β-strand	165	1	17
α-helix	173-175	3
β-strand	178-187	10	17
α-helix	189-192	4
β-strand	193-203	11	18
β-strand	208-213	6	18
α-helix	225-227	3
α-helix	230-232	3
β-strand	234	1	19
β-strand	240	1	19
β-strand	242-243	2	18
β-strand	249-253	5	18
β-strand	254-260	7	17
α-helix	261	1
α-helix	262-264	3
β-strand	273-278	6	17
β-strand	291-301	11	17
β-strand	317	1	20
β-strand	318-327	10	17
α-helix	344-354	11
α-helix	359-365	7
α-helix	375-385	11
α-helix	387-390	4
β-strand	391-392	2	21
β-strand	398-399	2	21
β-strand	405-409	5	22
α-helix	415-424	10
β-strand	429-433	5	22
β-strand	437	1	23
α-helix	439-443	5
β-strand	444-448	5	24
β-strand	455-459	5	24
α-helix	461-464	4
β-strand	469-473	5	22
α-helix	475-477	3
α-helix	480-492	13
β-strand	494-499	6	25
β-strand	502-507	6	25
β-strand	511-516	6	22
α-helix	537-541	5
β-strand	545-549	5	22
α-helix	556-569	14
α-helix	653-665	13
β-strand	670	1	26
α-helix	673-688	16
α-helix	700-716	17
β-strand	720	1	26
α-helix	723-737	15

Chain 4: 32 helices, 31 β-strands

Element	Residues	Length	Sheet
β-strand	178-180	3	27
β-strand	185-186	2	27
α-helix	187-200	14
β-strand	202	1	28
α-helix	203-208	6
α-helix	218-220	3
β-strand	224	1	28
α-helix	225-236	12
β-strand	240-244	5	29
α-helix	246-250	5
α-helix	252-254	3
α-helix	255-263	9
α-helix	265-286	22
α-helix	293-298	6
α-helix	300-301	2
β-strand	302-306	5	29
α-helix	310-313	4
α-helix	319-321	3
β-strand	324-335	12	30
α-helix	336-338	3
β-strand	339-349	11	30
β-strand	355-359	5	30
β-strand	360-361	2	31
β-strand	364-365	2	31
β-strand	382-384	3	30
β-strand	390-401	12	30
α-helix	411-413	3
β-strand	414-420	7	30
α-helix	421-423	3
β-strand	432-445	14	30
β-strand	453-455	3	30
β-strand	456	1	32
β-strand	457-468	12	30
α-helix	507-513	7
α-helix	518-526	9
α-helix	534-545	12
β-strand	550	1	33
β-strand	558	1	33
β-strand	564-567	4	34
α-helix	575-584	10
β-strand	588-592	5	34
β-strand	604-605	2	35
β-strand	616-617	2	35
α-helix	620-623	4
β-strand	628-632	5	34
α-helix	634-636	3
α-helix	639-649	11
β-strand	653-658	6	36
β-strand	661-666	6	36
β-strand	670-675	6	34
α-helix	688-690	3
α-helix	696-699	4
β-strand	704-707	4	34
α-helix	717-729	13
α-helix	744-757	14
α-helix	766-778	13
α-helix	795-812	18
α-helix	820-834	15
α-helix	852-875	24
α-helix	883-893	11
α-helix	900-912	13
β-strand	916-919	4	37
β-strand	923-926	4	37

Chain 5: 33 helices, 27 β-strands

Element	Residues	Length	Sheet
α-helix	21-37	17
α-helix	45-55	11
β-strand	61-64	4	38
α-helix	65-71	7
α-helix	73-81	9
α-helix	87-102	16
β-strand	137-140	4	38
α-helix	143-147	5
α-helix	153-155	3
β-strand	159-183	25	20
β-strand	189-193	5	20
β-strand	241-259	19	20
α-helix	260-261	2
α-helix	262-264	3
α-helix	265-266	2
α-helix	271-273	3
β-strand	274-279	6	20
α-helix	280-282	3
β-strand	291-297	7	20
β-strand	300	1	39
β-strand	326	1	39
β-strand	328-334	7	20
α-helix	351-361	11
α-helix	366-373	8
α-helix	382-393	12
β-strand	398-399	2	40
β-strand	405-406	2	40
β-strand	412-416	5	41
α-helix	422-432	11
β-strand	436-439	4	41
β-strand	444	1	13
α-helix	446-449	4
β-strand	452-455	4	42
β-strand	462-465	4	42
α-helix	468-471	4
β-strand	476-479	4	41
α-helix	487-490	4
α-helix	494-497	4
β-strand	501-506	6	23
β-strand	509-514	6	23
β-strand	518-523	6	41
α-helix	536-539	4
α-helix	544-549	6
β-strand	552-556	5	41
α-helix	562-577	16
α-helix	579-590	12
α-helix	596-609	14
β-strand	613-614	2	43
α-helix	616-638	23
α-helix	650-666	17
β-strand	671-672	2	43
α-helix	674-684	11
α-helix	685-689	5
α-helix	690-692	3
α-helix	709-721	13
β-strand	727-729	3	44
α-helix	730-737	8
α-helix	745-757	13
β-strand	761-764	4	44
β-strand	769-772	4	44

Chain 6: 30 helices, 33 β-strands

Element	Residues	Length	Sheet
β-strand	94-97	4	45
α-helix	102-104	3
α-helix	106-120	15
α-helix	135-146	12
β-strand	150-154	5	46
α-helix	155-160	6
α-helix	165-172	8
α-helix	174-192	19
α-helix	194-197	4
β-strand	198	1	47
β-strand	260	1	47
β-strand	264-268	5	46
β-strand	274	1	8
α-helix	281-283	3
β-strand	287-296	10	8
β-strand	301-311	11	8
β-strand	317-322	6	8
β-strand	344-346	3	8
β-strand	352-362	11	8
α-helix	373-375	3
β-strand	376-382	7	8
α-helix	383-385	3
α-helix	390	1
β-strand	394-405	12	8
α-helix	408-410	3
β-strand	437	1	48
β-strand	438	1	31
β-strand	448	1	48
β-strand	450-461	12	8
α-helix	501-507	7
α-helix	510-520	11
α-helix	525-532	8
α-helix	541-552	12
β-strand	557-558	2	49
β-strand	564-565	2	49
β-strand	571-575	5	50
α-helix	581-591	11
β-strand	595-599	5	50
β-strand	611-614	4	51
β-strand	621-624	4	51
α-helix	625	1
α-helix	627-630	4
β-strand	634-639	6	50
α-helix	646-655	10
β-strand	660-665	6	11
β-strand	668-673	6	11
β-strand	676-682	7	50
α-helix	683-684	2
α-helix	689-690	2
α-helix	695-698	4
α-helix	703-707	5
β-strand	711-715	5	50
α-helix	721-733	13
α-helix	748-760	13
β-strand	764	1	52
α-helix	767-782	16
β-strand	785	1	53
α-helix	787-789	3
β-strand	791	1	14
β-strand	792	1	53
α-helix	797-813	17
β-strand	818	1	52
α-helix	821-835	15

Chain 7: 29 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	18
α-helix	14-27	14
α-helix	62-71	10
β-strand	77-81	5	54
α-helix	82-95	14
α-helix	102-108	7
α-helix	110-123	14
α-helix	125-128	4
α-helix	138-153	16
β-strand	201-205	5	54
β-strand	225	1	55
α-helix	232-234	3
β-strand	238-248	11	55
β-strand	252-262	11	32
β-strand	268-272	5	32
β-strand	277-278	2	30
β-strand	283	1	56
α-helix	287-291	5
α-helix	296	1
β-strand	297	1	56
β-strand	298-310	13	32
β-strand	311-317	7	55
α-helix	323	1
α-helix	327-329	3
β-strand	330-335	6	55
α-helix	337-339	3
β-strand	348-358	11	55
α-helix	363-368	6
β-strand	371	1	18
β-strand	373-383	11	55
α-helix	397-407	11
α-helix	410-417	8
α-helix	426-437	12
β-strand	442	1	57
β-strand	450	1	57
β-strand	456-458	3	58
α-helix	466-476	11
β-strand	481-484	4	58
β-strand	498	1	59
α-helix	506	1
β-strand	507	1	59
α-helix	512-515	4
β-strand	519-524	6	58
α-helix	531-542	12
β-strand	545-550	6	60
β-strand	553-558	6	60
β-strand	561-566	6	58
α-helix	580-584	5
α-helix	588-593	6
β-strand	596-598	3	58
α-helix	606-618	13
α-helix	632-633	2
α-helix	638-648	11
α-helix	654-672	19
α-helix	686-702	17
α-helix	710-728	19

Chain 8: 34 helices, 31 β-strands

Element	Residues	Length	Sheet
β-strand	1322-1328	7	61
β-strand	1335-1342	8	61
β-strand	1345-1352	8	61
β-strand	1355-1361	7	62
β-strand	1375-1378	4	62
β-strand	1397-1402	6	62
α-helix	1404-1409	6
α-helix	1417-1419	3
β-strand	1423-1427	5	62
α-helix	1433-1441	9
β-strand	1444-1447	4	61
α-helix	1455-1461	7
β-strand	1463	1	61
α-helix	1465-1467	3
β-strand	1468-1470	3	61
β-strand	1484-1491	8	63
β-strand	1497-1503	7	63
β-strand	1508-1514	7	63
α-helix	1525-1543	19
β-strand	1557-1563	7	63
α-helix	1567-1584	18
β-strand	1589-1593	5	63
α-helix	1598-1603	6
α-helix	1606-1609	4
β-strand	1612-1614	3	63
α-helix	1618-1620	3
α-helix	1628-1656	29
α-helix	1669-1682	14
α-helix	1698-1700	3
α-helix	1707-1714	8
β-strand	1721-1722	2	64
β-strand	1725-1727	3	64
β-strand	1731-1737	7	64
α-helix	1739-1745	7
α-helix	1747-1750	4
α-helix	1782-1784	3
α-helix	1785-1802	18
α-helix	1807-1821	15
α-helix	1830-1852	23
β-strand	1857-1861	5	64
β-strand	1865-1869	5	64
α-helix	1875-1891	17
β-strand	1899-1913	15	64
β-strand	1916-1922	7	64
β-strand	1934-1937	4	64
α-helix	1941-1943	3
α-helix	1950-1976	27
α-helix	2003-2005	3
α-helix	2008-2025	18
α-helix	2032-2034	3
α-helix	2036-2038	3
α-helix	2050-2062	13
α-helix	2069-2079	11
β-strand	2102-2107	6	65
β-strand	2114-2118	5	65
β-strand	2129	1	66
β-strand	2136	1	66
α-helix	2137-2138	2
α-helix	2139-2158	20
β-strand	2162-2164	3	67
β-strand	2170	1	67
α-helix	2183-2184	2
β-strand	2185-2187	3	67
α-helix	2191-2208	18
α-helix	2211-2221	11

Chain 9: 28 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	2-5	4
α-helix	8-9	2
α-helix	19-21	3
α-helix	22-27	6
β-strand	34	1	68
α-helix	35-49	15
α-helix	51-53	3
α-helix	57-73	17
α-helix	81-102	22
α-helix	166-168	3
β-strand	171-173	3	69
α-helix	179	1
β-strand	180-184	5	70
β-strand	189-193	5	70
α-helix	202-205	4
α-helix	213-230	18
α-helix	233-235	3
β-strand	268	1	71
α-helix	271-273	3
β-strand	280-290	11	71
β-strand	296-300	5	71
β-strand	303-308	6	71
β-strand	313-314	2	71
α-helix	315	1
β-strand	325-333	9	71
β-strand	338-345	8	71
α-helix	346-349	4
α-helix	352-359	8
β-strand	362	1	72
β-strand	378	1	72
α-helix	381-393	13
β-strand	399-402	4	73
β-strand	404	1	74
α-helix	411-426	16
β-strand	431-434	4	73
α-helix	452-453	2
α-helix	454-469	16
α-helix	473-478	6
β-strand	480-483	4	73
α-helix	493-496	4
α-helix	505-509	5
α-helix	510-512	3
α-helix	514-517	4
β-strand	523-525	3	73
β-strand	530-534	5	69
β-strand	537-543	7	69
α-helix	546-552	7
α-helix	594-609	16
β-strand	611	1	75
β-strand	631	1	75
β-strand	638-642	5	69
β-strand	649-653	5	69
β-strand	656-660	5	69
β-strand	663	1	74
β-strand	665	1	73
β-strand	669-676	8	73
β-strand	681-688	8	73

19 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA replication licensing factor MCM2	2	protein	868	Saccharomyces cerevisiae	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3	protein	971	Saccharomyces cerevisiae	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4	protein	933	Saccharomyces cerevisiae	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5	protein	775	Saccharomyces cerevisiae	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6	protein	1017	Saccharomyces cerevisiae	P53091
DNA replication licensing factor MCM7	7	protein	845	Saccharomyces cerevisiae	P38132
DNA polymerase epsilon catalytic subunit A	8	protein	2222	Saccharomyces cerevisiae	P21951
DNA polymerase epsilon subunit B	9	protein	689	Saccharomyces cerevisiae	P24482
DNA replication complex GINS protein PSF1	A	protein	208	Saccharomyces cerevisiae	Q12488
DNA replication complex GINS protein PSF2	B	protein	251	Saccharomyces cerevisiae	P40359
DNA replication complex GINS protein PSF3	C	protein	194	Saccharomyces cerevisiae	Q12146
DNA replication complex GINS protein SLD5	D	protein	294	Saccharomyces cerevisiae	Q03406

13 more molecules are not listed.

Sequence of entity 1 (2), FASTA

>8XGC_1 DNA replication licensing factor MCM2 (chains 2)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 2 (3), FASTA

>8XGC_2 DNA replication licensing factor MCM3 (chains 3)
MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQ
DDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY
FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLV
SVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNK
LTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIF
DILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLR
FVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTD
VDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLL
SRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINP
EEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYV
QYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKT
VNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSG
SPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQL
GLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTIST
GRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNN
LMVADDKVWRV

Sequence of entity 3 (4), FASTA

>8XGC_3 DNA replication licensing factor MCM4 (chains 4)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 4 (5), FASTA

>8XGC_4 Minichromosome maintenance protein 5 (chains 5)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 5 (6), FASTA

>8XGC_5 DNA replication licensing factor MCM6 (chains 6)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 6 (7), FASTA

>8XGC_6 DNA replication licensing factor MCM7 (chains 7)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 7 (8), FASTA

>8XGC_7 DNA polymerase epsilon catalytic subunit A (chains 8)
MMFGKKKNNGGSSTARYSAGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQY
NGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNSNDGERVTTNQGISGVDFY
FLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNH
LLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIYNVAANGSEKVDAKHLIE
DIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKF
PDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQ
RFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHM
DCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVA
TYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIE
RFYDGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVEN
KSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIK
AERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKV
LTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDR
RYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSR
WYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKK
LYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKE
EGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVA
SVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGED
MVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTI
IDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIATKEDKFKQTSLTKFF
SKTKNVPTMGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVSKRKRNQLTNEEDPLVLPS
EIPSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNTNSSRERSALGSMIRKQAESYANS
TWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLQKIKNCLIEKSS
ASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQRAIMD
LGASVTFRSKAMGALGKGIQQGFEMKDLSMAENERYLSGFSMDIGYLLHFPTSIGYEFFS
LFKSWGDTITILVLKPSNQAQEINASSLGQIYKQMFEKKKGKIETYSYLVDIKEDINFEF
VYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPFITKLLGTIRLLNQMPIVKLSLNEV
LLPQLNWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSMDYIIDVLYARKL
KKENIVLWWNEKAPLPDHGGIQNDFDLNTSWIMNDSEFPKINNSGVYDNVVLDVGVDNLT
VNTILTSALINDAEGSDLVNNNMGIDDKDAVINSPSEFVHDAFSNDALNVLRGMLKEWWD
EALKENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNLTKKALLQLVNEFSALGSTIVY
ADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPMFSYLDLNIKRYWDLLIWMDKFNFSGL
ACIEIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMMIILDSMLKTKQSYLKLNSGTQR
PTQIVNVKKQDKEDSVENSLNGFSHLFSKPLMKRVKKLFKNQQEFILDPQYEADYVIPVL
PGSHLNVKNPLLELVKSLCHVMLLSKSTILEIRTLRKELLKIFELREFAKVAEFKDPSLS
LVVPDFLCEYCFFISDIDFCKAAPESIFSCVRCHKAFNQVLLQEHLIQKLRSDIESYLIQ
DLRCSRCHKVKRDYMSAHCPCAGAWEGTLPRESIVQKLNVFKQVAKYYGFDILLSCIADL
TI

Sequence of entity 8 (9), FASTA

>8XGC_8 DNA polymerase epsilon subunit B (chains 9)
MFGSGNVLPVKIQPPLLRPLAYRVLSRKYGLSIKSDGLSALAEFVGTNIGANWRQGPATI
KFLEQFAAVWKQQERGLFIDQSGVKEVIQEMKEREKVEWSHEHPIQHEENILGRTDDDEN
NSDDEMPIAADSSLQNVSLSSPMRQPTERDEYKQPFKPESSKALDWRDYFKVINASQQQR
FSYNPHKMQFIFVPNKKQNGLGGIAGFLPDIEDKVQMFLTRYYLTNDRVMRNENFQNSDM
FNPLSSMVSLQNELSNTNRQQQSSSMSITPIKNLLGRDAQNFLLLGLLNKNFKGNWSLED
PSGSVEIDISQTIPTQGHYYVPGCMVLVEGIYYSVGNKFHVTSMTLPPGERREITLETIG
NLDLLGIHGISNNNFIARLDKDLKIRLHLLEKELTDHKFVILGANLFLDDLKIMTALSKI
LQKLNDDPPTLLIWQGSFTSVPVFASMSSRNISSSTQFKNNFDALATLLSRFDNLTENTT
MIFIPGPNDLWGSMVSLGASGTLPQDPIPSAFTKKINKVCKNVVWSSNPTRIAYLSQEIV
IFRDDLSGRFKRHRLEFPFNESEDVYTENDNMMSKDTDIVPIDELVKEPDQLPQKVQETR
KLVKTILDQGHLSPFLDSLRPISWDLDHTLTLCPIPSTMVLCDTTSAQFDLTYNGCKVIN
PGSFIHNRRARYMEYVPSSKKTIQEEIYI

Sequence of entity 9 (A), FASTA

>8XGC_9 DNA replication complex GINS protein PSF1 (chains A)
MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQL
GMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDT
NNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGV
FNLIKDSQFFVRQSDVERLIQQGYLQKI

Sequence of entity 10 (B), FASTA

>8XGC_10 DNA replication complex GINS protein PSF2 (chains B)
MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKAL
NNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWL
VLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINE
LRPFITEIMDKLREIHTASLTAGTENDEEEFNIENLYFQGSGGGGGGSRDYKDHDGDYKD
HDIDYKDDDDK

Sequence of entity 11 (C), FASTA

>8XGC_11 DNA replication complex GINS protein PSF3 (chains C)
MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGD
EALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKEL
ANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKS
HESYKDTKRWMFKK

Sequence of entity 12 (D), FASTA

>8XGC_12 DNA replication complex GINS protein SLD5 (chains D)
MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDF
SDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPN
ESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEI
KYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKW
NEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	5

Primary citation

Parental histone transfer caught at the replication fork. Li, N., Gao, Y., Zhang, Y. et al. Nature (2024) 627:890-897. DOI 10.1038/s41586-024-07152-2 · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
8KG6 3.07 Å, Yeast replisome in state I
9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD

Browse structure collections

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