8XX7: CXCR2

Structure of CXCR2 bound to CXCL5 (CXCR2-CXCL5-Go Full map). Determined by electron microscopy at 3.32 Å resolution. Released 15 Jan 2025.

Method: Electron microscopy
Resolution: 3.32 Å
Organism: Homo sapiens
Chains: 10
Atoms: 15,054
Mol. weight: 256.97 kDa
Released: 15 Jan 2025

Explore 8XX7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8XX7 contains 70 α-helices and 84 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and F: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	7-29	23
β-strand	33-40	8	4
β-strand	186-188	3	4
β-strand	191-192	2	4
β-strand	195-201	7	4
α-helix	209-211	3
α-helix	213-216	4
β-strand	221-227	7	4
α-helix	244-255	12
β-strand	265-270	6	4
α-helix	272-281	10
α-helix	297-309	13
β-strand	319-323	5	4
α-helix	331-351	21

Chains B and D: 3 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	19	1	1
α-helix	24-26	3
β-strand	27-33	7	1
α-helix	34	1
β-strand	43-48	6	1
β-strand	53-56	4	1
α-helix	61-70	10

Chains C and R: 17 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	32-35	4
α-helix	45-75	31
α-helix	82-110	29
α-helix	116-148	33
α-helix	155-159	5
α-helix	162-176	15
α-helix	178-183	6
β-strand	184-187	4	3
β-strand	195-198	4	3
α-helix	204-211	8
α-helix	213-216	4
α-helix	217-221	5
α-helix	222-239	18
α-helix	246-278	33
α-helix	283-284	2
α-helix	286-303	18
α-helix	306-310	5
α-helix	311-315	5
α-helix	319-328	10

Chains E and H: 4 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	6-25	20
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-52	6	5
β-strand	58-63	6	6
β-strand	69-74	6	6
β-strand	78-83	6	6
β-strand	88-94	7	6
β-strand	100-103	4	7
β-strand	111-113	3	8
β-strand	114-116	3	7
β-strand	121-125	5	8
β-strand	134-139	6	8
β-strand	146-153	8	9
β-strand	156-161	6	9
β-strand	165-169	5	9
β-strand	176-181	6	9
β-strand	187-192	6	10
β-strand	198-203	6	10
β-strand	207-212	6	10
β-strand	218-223	6	10
β-strand	229-234	6	11
β-strand	240-245	6	11
β-strand	250-254	5	11
β-strand	260-263	4	11
α-helix	272	1
β-strand	273-278	6	12
β-strand	284-289	6	12
β-strand	294-298	5	12
β-strand	303-307	5	12
β-strand	315-320	6	5
β-strand	327-331	5	5
β-strand	335-339	5	5

Chains G and I: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	13-23	11
α-helix	30-43	14
α-helix	54-55	2
α-helix	56-58	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C-X-C motif chemokine 5	B, D	protein	78	Homo sapiens	P42830 (AlphaFold model)
C-X-C chemokine receptor type 2	C, R	protein	416	Homo sapiens	P25025 (AlphaFold model)
Guanine nucleotide-binding protein G(o) subunit alpha	A, F	protein	240	Homo sapiens	P09471 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	E, H	protein	350	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	G, I	protein	71	Homo sapiens	P59768

Sequence of entity 1 (B, D), FASTA

>8XX7_1 C-X-C motif chemokine 5 (chains B, D)
AGPAAAVLRELRCVCLQTTQGVHPKMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEA
PFLKKVIQKILDGGNKEN

Sequence of entity 2 (C, R), FASTA

>8XX7_2 C-X-C chemokine receptor type 2 (chains C, R)
MGKTIIALSYIFCLVFADYKDDDDAANFTPVNGSSGNQSVRLVTSSSLEVLFQGPGSEDF
NMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLL
GNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSL
LKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFR
RTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG
QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGI
LHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

Sequence of entity 3 (A, F), FASTA

>8XX7_3 Guanine nucleotide-binding protein G(o) subunit alpha (chains A, F)
MGHHHHHHENLYFQGTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGADNSGKST
IVKQMKIIHGGSGGSGGTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIF
CVDLSDYNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGP
NTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNAQVIFDAVTDIIIANNLRGCGLY

Sequence of entity 4 (E, H), FASTA

>8XX7_4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains E, H)
MHHHHHHGSSGSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRT
LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN
YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWD
IETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDIN
AICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYD
DFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 5 (G, I), FASTA

>8XX7_5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains G, I)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Primary citation

Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2. Saha, S., Sano, F.K., Sharma, S. et al. Mol Cell (2025) 85:976-988.e9. DOI 10.1016/j.molcel.2025.01.024 · PubMed

Other PDB entries of the same protein (UniProt P42830 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8XWS 3.06 Å, Structure of CXCR2 bound to CXCL5 (Ligand-receptor focused map)
2MGS Solution structure of CXCL5

Browse structure collections

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