9GJP: DNA replication licensing factor MCM2

Name: PDB 9GJP: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2
Published: 2025-03-05
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: replication

OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. Determined by electron microscopy at 3.4 Å resolution. Released 5 Mar 2025.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Saccharomyces cerevisiae, synthetic construct
Chains: 15
Atoms: 50,292
Mol. weight: 1126.35 kDa
Ligands: ADP, ZN, ATP
Released: 5 Mar 2025

Explore 9GJP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9GJP contains 328 α-helices and 230 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 35 helices, 25 β-strands

Element	Residues	Length	Sheet
α-helix	186-188	3
α-helix	194-198	5
α-helix	201-216	16
α-helix	221-223	3
α-helix	226-237	12
β-strand	243-245	3	1
α-helix	246-252	7
α-helix	254-258	5
α-helix	259-261	3
α-helix	264-282	19
α-helix	286-288	3
β-strand	296-298	3	1
α-helix	311-313	3
β-strand	317-327	11	2
β-strand	331-337	7	2
β-strand	339-341	3	3
β-strand	347	1	3
α-helix	348-350	3
β-strand	351-352	2	2
β-strand	373-375	3	3
α-helix	377-379	3
β-strand	381-391	11	2
α-helix	394-396	3
α-helix	397-398	2
β-strand	405-411	7	2
β-strand	423-432	10	2
α-helix	438-441	4
β-strand	446	1	4
β-strand	449-457	9	2
α-helix	478-488	11
α-helix	494-499	6
α-helix	509-520	12
α-helix	537-538	2
β-strand	539-543	5	5
α-helix	553-559	7
β-strand	563-567	5	5
β-strand	571	1	6
α-helix	573-576	4
β-strand	578-582	5	7
β-strand	589-593	5	7
α-helix	595-598	4
β-strand	602-607	6	5
α-helix	614-618	5
α-helix	620-626	7
β-strand	628-633	6	8
β-strand	636-641	6	8
β-strand	644-650	7	5
α-helix	653-655	3
α-helix	663-666	4
α-helix	671-675	5
β-strand	679-683	5	5
α-helix	689-706	18
α-helix	740-755	16
α-helix	760-773	14
β-strand	777	1	9
α-helix	783-796	14
α-helix	807-823	17
β-strand	828	1	9
α-helix	831-847	17
α-helix	851-860	10

Chain 3: 29 helices, 26 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	36-51	16
β-strand	95-99	5	10
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-135	18
α-helix	144-146	3
α-helix	148-150	3
β-strand	154-158	5	10
β-strand	165-166	2	11
α-helix	173-175	3
β-strand	178-189	12	11
β-strand	193-203	11	11
β-strand	208-213	6	11
α-helix	224-226	3
α-helix	229-230	2
α-helix	232	1
β-strand	234	1	12
α-helix	239	1
β-strand	240	1	12
β-strand	241-243	3	11
β-strand	249-259	11	11
α-helix	262-264	3
α-helix	265-266	2
β-strand	273-279	7	11
α-helix	280-282	3
β-strand	291-301	11	11
β-strand	318-328	11	11
α-helix	344-353	10
α-helix	359-366	8
α-helix	375-386	12
β-strand	391-392	2	13
β-strand	398-399	2	13
β-strand	405-409	5	14
α-helix	415-425	11
β-strand	429-433	5	14
β-strand	447-449	3	15
β-strand	455-457	3	15
α-helix	461-464	4
β-strand	469-473	5	14
α-helix	475-477	3
α-helix	480-492	13
β-strand	494-499	6	16
β-strand	502-507	6	16
β-strand	511-516	6	14
α-helix	529-532	4
α-helix	537-540	4
β-strand	545-549	5	14
α-helix	555-567	13
α-helix	653-666	14
β-strand	670	1	17
α-helix	673-688	16
α-helix	699-716	18
β-strand	720	1	17
α-helix	723-737	15

Chain 4: 31 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	187-200	14
α-helix	226-235	10
β-strand	240-243	4	18
α-helix	246-249	4
α-helix	252-261	10
α-helix	265-281	17
α-helix	282-286	5
α-helix	294-298	5
β-strand	302-305	4	18
α-helix	308-310	3
α-helix	319-321	3
β-strand	325-335	11	19
α-helix	336-338	3
β-strand	339-349	11	20
β-strand	355-359	5	20
β-strand	364-365	2	21
β-strand	370	1	22
β-strand	379	1	22
β-strand	382-384	3	20
α-helix	386-388	3
β-strand	390-395	6	20
β-strand	397-401	5	19
β-strand	414-418	5	19
β-strand	419-420	2	20
α-helix	421-423	3
β-strand	432-440	9	19
β-strand	460-468	9	19
α-helix	503-514	12
α-helix	518-526	9
α-helix	534-545	12
β-strand	564-566	3	23
α-helix	575-584	10
β-strand	589-592	4	23
α-helix	598-601	4
β-strand	603-606	4	24
β-strand	613	1	25
β-strand	615-618	4	24
α-helix	620-623	4
β-strand	628-632	5	23
α-helix	634-636	3
α-helix	639-651	13
β-strand	653-658	6	26
β-strand	661-666	6	26
β-strand	670-674	5	23
α-helix	676-677	2
α-helix	688-691	4
α-helix	696-701	6
β-strand	704-706	3	23
α-helix	714-725	12
α-helix	744-757	14
β-strand	761-762	2	27
α-helix	764-778	15
α-helix	796-812	17
β-strand	816-817	2	27
α-helix	819-833	15
β-strand	838	1	28
β-strand	845	1	28
α-helix	856-875	20
α-helix	883-891	9
α-helix	904-912	9

Chain 5: 35 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	25-32	8
α-helix	33-37	5
β-strand	40	1	29
β-strand	43	1	29
α-helix	45-56	12
β-strand	60-64	5	30
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-105	23
α-helix	134-135	2
β-strand	136-140	5	30
α-helix	144-147	4
α-helix	148-150	3
β-strand	158-169	12	31
β-strand	173-178	6	31
β-strand	179-183	5	32
β-strand	189-192	4	32
β-strand	241-243	3	32
α-helix	245-247	3
β-strand	249-259	11	31
α-helix	262-264	3
α-helix	266	1
α-helix	270-272	3
β-strand	273-279	7	31
α-helix	280-282	3
β-strand	291-301	11	31
α-helix	324	1
β-strand	325-334	10	31
α-helix	351-361	11
α-helix	366-373	8
α-helix	382-393	12
β-strand	399	1	33
β-strand	405	1	33
β-strand	412-414	3	34
α-helix	422-430	9
β-strand	436-440	5	34
β-strand	444	1	8
α-helix	446-449	4
β-strand	452-456	5	31
β-strand	461-465	5	31
α-helix	468-471	4
β-strand	476-480	5	34
α-helix	482-484	3
α-helix	487-499	13
β-strand	501-506	6	35
β-strand	509-514	6	35
β-strand	518-522	5	34
α-helix	544-548	5
β-strand	552-554	3	34
α-helix	563-577	15
α-helix	579-590	12
α-helix	596-609	14
β-strand	613	1	36
α-helix	616-632	17
α-helix	650-667	18
β-strand	671	1	36
α-helix	674-688	15
α-helix	707-721	15
β-strand	727-728	2	37
α-helix	730-733	4
α-helix	734-738	5
α-helix	745-757	13
β-strand	761-764	4	37
α-helix	765-767	3
β-strand	769-772	4	37

Chain 6: 33 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	102-104	3
α-helix	106-121	16
α-helix	135-146	12
β-strand	150-154	5	38
α-helix	155-158	4
α-helix	162-164	3
α-helix	165-172	8
α-helix	174-192	19
α-helix	194-197	4
β-strand	264-268	5	38
β-strand	273-274	2	4
α-helix	276-278	3
α-helix	281-283	3
β-strand	284	1	4
β-strand	287-297	11	4
β-strand	301-311	11	4
β-strand	317-322	6	4
β-strand	344-346	3	4
β-strand	352-362	11	4
α-helix	369	1
β-strand	375	1	25
β-strand	376-382	7	4
α-helix	383-385	3
β-strand	394-404	11	4
β-strand	418-419	2	21
β-strand	446	1	21
β-strand	451-461	11	4
α-helix	501-505	5
α-helix	510-517	8
α-helix	525-530	6
α-helix	541-550	10
β-strand	557-558	2	39
β-strand	564-565	2	39
β-strand	571-575	5	40
α-helix	582-591	10
β-strand	595-599	5	40
α-helix	605-608	4
β-strand	610-614	5	41
α-helix	615	1
β-strand	621-625	5	41
β-strand	634-639	6	40
α-helix	641-643	3
α-helix	646-649	4
α-helix	650-652	3
α-helix	653-657	5
β-strand	660-662	3	42
β-strand	664	1	6
β-strand	671-673	3	42
β-strand	676-682	7	40
α-helix	695-698	4
α-helix	703-708	6
β-strand	711-715	5	40
α-helix	721-736	16
α-helix	748-758	11
β-strand	764-765	2	43
α-helix	767-782	16
α-helix	797-812	16
β-strand	818-819	2	43
α-helix	821-832	12
α-helix	906-926	21
α-helix	933-942	10
α-helix	951-970	20
β-strand	974-977	4	44
β-strand	998-1001	4	44

Chain 7: 32 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	11
α-helix	14-27	14
β-strand	29	1	45
β-strand	61	1	45
α-helix	62-71	10
β-strand	77-81	5	46
α-helix	82-95	14
α-helix	102-108	7
α-helix	110-124	15
α-helix	194-197	4
β-strand	201-205	5	46
α-helix	206-208	3
α-helix	209-214	6
β-strand	225	1	47
α-helix	227-229	3
α-helix	232-234	3
β-strand	237-248	12	47
α-helix	249-251	3
β-strand	252-257	6	47
β-strand	259-262	4	48
β-strand	268-270	3	48
β-strand	283	1	49
α-helix	287-291	5
α-helix	296	1
β-strand	297	1	49
β-strand	298-300	3	48
α-helix	302-304	3
β-strand	306-316	11	47
α-helix	319-321	3
α-helix	326-329	4
β-strand	330-336	7	47
α-helix	337-339	3
β-strand	348-356	9	47
β-strand	371	1	11
β-strand	375-383	9	47
α-helix	395-407	13
α-helix	410-417	8
α-helix	426-437	12
β-strand	442-445	4	50
β-strand	448-450	3	50
β-strand	456-459	4	51
α-helix	467-476	10
β-strand	480-484	5	51
β-strand	495-496	2	52
β-strand	509-510	2	52
α-helix	512-515	4
β-strand	519-524	6	51
α-helix	526-528	3
α-helix	531-543	13
β-strand	561-567	7	51
α-helix	588-591	4
β-strand	596	1	51
β-strand	599	1	51
α-helix	606-621	16
α-helix	632-634	3
α-helix	635-647	13
β-strand	651	1	53
α-helix	654-676	23
α-helix	686-702	17
β-strand	707	1	53
α-helix	710-724	15
α-helix	725-728	4

Chain 8: 25 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	17-19	3	54
α-helix	26-39	14
β-strand	42-46	5	54
α-helix	51-63	13
α-helix	69-71	3
β-strand	73	1	54
β-strand	79-82	4	54
α-helix	84-86	3
β-strand	87-95	9	54
α-helix	109-133	25
α-helix	137-139	3
β-strand	149-157	9	54
α-helix	187	1
β-strand	188-190	3	55
β-strand	196-199	4	54
β-strand	202-206	5	55
β-strand	221-224	4	55
β-strand	228-232	5	54
α-helix	234-239	6
β-strand	249-251	3	55
β-strand	258-263	6	54
β-strand	269	1	56
β-strand	277	1	56
α-helix	278-289	12
α-helix	291-297	7
α-helix	299-330	32
α-helix	336-338	3
β-strand	339	1	57
α-helix	340-351	12
α-helix	357-366	10
β-strand	372	1	58
α-helix	374-376	3
β-strand	382	1	57
β-strand	384	1	58
α-helix	393-416	24
α-helix	420-422	3
α-helix	425-428	4
α-helix	482-492	11
α-helix	494-512	19
α-helix	513-515	3
α-helix	517-523	7
β-strand	530	1	59
α-helix	531-538	8
α-helix	551-564	14
β-strand	573	1	60
β-strand	578	1	60
β-strand	579	1	59
α-helix	590-594	5

Chain A: 7 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	789-794	6
α-helix	799-815	17
β-strand	820-821	2	61
α-helix	822-834	13
α-helix	840-850	11
α-helix	866-875	10
β-strand	879-881	3	61
α-helix	887-889	3
β-strand	891-894	4	61
α-helix	898-906	9

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA replication licensing factor MCM2	2	protein	868	Saccharomyces cerevisiae	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3	protein	1006	Saccharomyces cerevisiae	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4	protein	933	Saccharomyces cerevisiae	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5	protein	775	Saccharomyces cerevisiae	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6	protein	1017	Saccharomyces cerevisiae	P53091
DNA replication licensing factor MCM7	7	protein	845	Saccharomyces cerevisiae	P38132
Cell division cycle protein CDT1	8	protein	604	Saccharomyces cerevisiae	P47112
Origin recognition complex subunit 1	A	protein	949	Saccharomyces cerevisiae	P54784
Origin recognition complex subunit 2	B	protein	620	Saccharomyces cerevisiae	P32833
Origin recognition complex subunit 3	C	protein	616	Saccharomyces cerevisiae	P54790
Origin recognition complex subunit 4	D	protein	529	Saccharomyces cerevisiae	P54791
Origin recognition complex subunit 5	E	protein	479	Saccharomyces cerevisiae	P50874

2 more molecules are not listed.

Sequence of entity 1 (2), FASTA

>9GJP_1 DNA replication licensing factor MCM2 (chains 2)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 2 (3), FASTA

>9GJP_2 DNA replication licensing factor MCM3 (chains 3)
MKRRWKKNFIAVSAANRFKKISSSGALENLYFQGEMEGSTGFDGDATTFFAPDAVFGDRV
RRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKKAAS
STSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNAS
AVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAK
TGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMA
PAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNT
VYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLML
MGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAA
VTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTT
LNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHV
LRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKF
NPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTD
LRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGND
IDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRI
LRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTE
VGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTISTGRLSLISGIIARLMQTEIFEEESYP
VASLFERINEELPEEEKFSAQEYLAGLKIMSDRNNLMVADDKVWRV

Sequence of entity 3 (4), FASTA

>9GJP_3 DNA replication licensing factor MCM4 (chains 4)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 4 (5), FASTA

>9GJP_4 Minichromosome maintenance protein 5 (chains 5)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSAFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 5 (6), FASTA

>9GJP_5 DNA replication licensing factor MCM6 (chains 6)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 6 (7), FASTA

>9GJP_6 DNA replication licensing factor MCM7 (chains 7)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 7 (8), FASTA

>9GJP_7 Cell division cycle protein CDT1 (chains 8)
MSGTANSRRKEVLRVPVIDLNRVSDEEQLLPVVRAILLQHDTFLLKNYANKAVLDALLAG
LTTKDLPDTSQGFDANFTGTLPLEDDVWLEQYIFDTDPQLRFDRKCRNESLCSIYSRLFK
LGLFFAQLCVKSVVSSAELQDCISTSHYATKLTRYFNDNGSTHDGADAGATVLPTGDDFQ
YLFERDYVTFLPTGVLTIFPCAKAIRYKPSTMATTDNSWVSIDEPDCLLFHTGTLLARWS
QGMHTTSPLQIDPRANIVSLTIWPPLTTPISSKGEGTIANHLLEQQIKAFPKVAQQYYPR
ELSILRLQDAMKFVKELFTVCETVLSLNALSRSTGVPPELHVLLPQISSMMKRKIVQDDI
LKLLTIWSDAYVVELNSRGELTMNLPKRDNLTTLTNKSRTLAFVERAESWYQQVIASKDE
IMTDVPAFKINKRRSSSNSKTVLSSKVQTKSSNANALNNSRYLANSKENFMYKEKMPDSQ
ANLMDRLRERERRSAALLSQRQKRYQQFLAMKMTQVFDILFSLTRGQPYTETYLSSLIVD
SLQDSNNPIGTKEASEILAGLQGILPMDISVHQVDGGLKVYRWNSLDKNRFSKLLQIHKS
KQQD

Sequence of entity 8 (A), FASTA

>9GJP_8 Origin recognition complex subunit 1 (chains A)
MKRRWKKNFIAVSAANRFKKISSSGALENLYFQGEMAKTLKDLQGWEIITTDEQGNIIDG
GQKRLRRRGAKTEHYLKRSSDGIKLGRGDSVVMHNEAAGTYSVYMIQELRLNTLNNVVEL
WALTYLRWFEVNPLAHYRQFNPDANILNRPLNYYNKLFSETANKNELYLTAELAELQLFN
FIRVANVMDGSKWEVLKGNVDPERDFTVRYICEPTGEKFVDINIEDVKAYIKKVEPREAQ
EYLKDLTLPSKKKEIKRGPQKKDKATQTAQISDAETRATDITDNEDGNEDESSDYESPSD
IDVSEDMDSGEISADELEEEEDEEEDEDEEEKEARHTNSPRKRGRKIKLGKDDIDASVQP
PPKKRGRKPKDPSKPRQMLLISSCRANNTPVIRKFTKKNVARAKKKYTPFSKRFKSIAAI
PDLTSLPEFYGNSSELMASRFENKLKTTQKHQIVETIFSKVKKQLNSSYVKEEILKSANF
QDYLPARENEFASIYLSAYSAIESDSATTIYVAGTPGVGKTLTVREVVKELLSSSAQREI
PDFLYVEINGLKMVKPTDCYETLWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLL
DELDAMVTKSQDIMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMFT
GYTHEELKNIIDLRLKGLNDSFFYVDTKTGNAILIDAAGNDTTVKQTLPEDVRKVRLRMS
ADAIEIASRKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGKTVIEDENEEQIYD
DEDKDLIESNKAKDDNDDDDDNDGVQTVHITHVMKALNETLNSHVITFMTRLSFTAKLFI
YALLNLMKKNGSQEQELGDIVDEIKLLIEVNGSNKFVMEIAKTLFQQGSDNISEQLRIIS
WDFVLNQLLDAGILFKQTMKNDRICCVKLNISVEEAKRAMNEDETLRNL

Sequence of entity 9 (B), FASTA

>9GJP_9 Origin recognition complex subunit 2 (chains B)
MLNGEDFVEHNDILSSPAKSRNVTPKRVDPHGERQLRRIHSSKKNLLERISLVGNERKNT
SPDPALKPKTPSKAPRKRGRPRKIQEELTDRIKKDEKDTISSKKKRKLDKDTSGNVNEES
KTSNNKQVMEKTGIKEKREREKIQVATTTYEDNVTPQTDDNFVSNSPEPPEPATPSKKSL
TTNHDFTSPLKQIIMNNLKEYKDSTSPGKLTLSRNFTPTPVPKNKKLYQTSETKSASSFL
DTFEGYFDQRKIVRTNAKSRHTMSMAPDVTREEFSLVSNFFNENFQKRPRQKLFEIQKKM
FPQYWFELTQGFSLLFYGVGSKRNFLEEFAIDYLSPKIAYSQLAYENELQQNKPVNSIPC
LILNGYNPSCNYRDVFKEITDLLVPAELTRSETKYWGNHVILQIQKMIDFYKNQPLDIKL
ILVVHNLDGPSIRKNTFQTMLSFLSVIRQIAIVASTDHIYAPLLWDNMKAQNYNFVFHDI
SNFEPSTVESTFQDVMKMGKSDTSSGAEGAKYVLQSLTVNSKKMYKLLIETQMQNMGNLS
ANTGPKRGTQRTGVELKLFNHLCAADFIASNEIALRSMLREFIEHKMANITKNNSGMEII
WVPYTYAELEKLLKTVLNTL

Sequence of entity 10 (C), FASTA

>9GJP_10 Origin recognition complex subunit 3 (chains C)
MSDLNQSKKMNVSEFADAQRSHYTVYPSLPQSNKNDKHIPFVKLLSGKESEVNVEKRWEL
YHQLHSHFHDQVDHIIDNIEADLKAEISDLLYSETTQKRRCFNTIFLLGSDSTTKIELKD
ESSRYNVLIELTPKESPNVRMMLRRSMYKLYSAADAEEHPTIKYEDINDEDGDFTEQNND
VSYDLSLVENFKRLFGKDLAMVFNFKDVDSINFNTLDNFIILLKSAFKYDHVKISLIFNI
NTNLSNIEKNLRQSTIRLLKRNYHKLDVSSNKGFKYGNQIFQSFLDTVDGKLNLSDRFVE
FILSKMANNTNHNLQLLTKMLDYSLMSYFFQNAFSVFIDPVNVDFLNDDYLKILSRCPTF
MFFVEGLIKQHAPADEILSLLTNKNRGLEEFFVEFLVRENPINGHAKFVARFLEEELNIT
NFNLIELYHNLLIGKLDSYLDRWSACKEYKDRLHFEPIDTIFQELFTLDNRSGLLTQSIF
PSYKSNIEDNLLSWEQVLPSLDKENYDTLSGDLDKIMAPVLGQLFKLYREANMTINIYDF
YIAFRETLPKEEILNFIRKDPSNTKLLELAETPDAFDKVALILFMQAIFAFENMGLIKFQ
STKSYDLVEKCVWRGI

Sequence of entity 11 (D), FASTA

>9GJP_11 Origin recognition complex subunit 4 (chains D)
MTISEARLSPQVNLLPIKRHSNEEVEETAAILKKRTIDNEKCKDSDPGFGSLQRRLLQQL
YGTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKESHSVILVGPRQSYKTYLLDYELSLLQ
QSYKEQFITIRLNGFIHSEQTAINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEV
FEKILLLLDSTTKTRNEDSGEVDRESITKITVVFIFDEIDTFAGPVRQTLLYNLFDMVEH
SRVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIYMPQIQNLDDMVDAVRNLLTVRSEISP
WVSQWNETLEKELSDPRSNLNRHIRMNFETFRSLPTLKNSIIPLVATSKNFGSLCTAIKS
CSFLDIYNKNQLSNNLTGRLQSLSDLELAILISAARVALRAKDGSFNFNLAYAEYEKMIK
AINSRIPTVAPTTNVGTGQSTFSIDNTIKLWLKKDVKNVWENLVQLDFFTEKSAVGLRDN
ATAAFYASNYQFQGTMIPFDLRSYQMQIILQELRRIIPKSNMYYSWTQL

Sequence of entity 12 (E), FASTA

>9GJP_12 Origin recognition complex subunit 5 (chains E)
MNVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKYFNANPNLHAV
WLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPLQVEEPFLLVKTLHNIFVQYE
SLQEKTCLFLILDGFDSLQDLDAALFNKYIKLNELLPKDSKINIKFIYTMLETSFLQRYS
THCIPTVMFPRYNVDEVSTILVMSRCGELMEDSCLRKRIIEEQITDCTDDQFQNVAANFI
HLIVQAFHSYTGNDIFALNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLS
ENGQGESAITTNRDDLENSQTYDLSIISKYLLIASYICSYLEPRYDASIFSRKTRIIQGR
AAYGRRKKKEVNPRYLQPSLFAIERLLAIFQAIFPIQGKAESGSLSALREESLMKANIEV
FQNLSELHTLKLIATTMNKNIDYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSDIHE

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	4
ZN	Zinc ion	Zn	5
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	2

Primary citation

Unidirectional MCM translocation away from ORC drives origin licensing. Butryn, A., Greiwe, J.F., Costa, A. Nat Commun (2025) 16:782-782. DOI 10.1038/s41467-025-56143-y · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
8KG6 3.07 Å, Yeast replisome in state I
9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD

Browse structure collections

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