9GNJ: PDB entry 9GNJ

Crystal structure of a PP2A B56gamma double phosphorylated BRCA2 complex. Determined by X-ray diffraction at 2.85 Å resolution. Released 24 Sept 2025.

Method: X-ray diffraction
Resolution: 2.85 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,825
Mol. weight: 42.92 kDa
Released: 24 Sept 2025

Explore 9GNJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9GNJ contains 24 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 0 β-strands

Element	Residues	Length
α-helix	37-48	12
α-helix	59-82	24
α-helix	91-103	13
α-helix	106-108	3
α-helix	131-145	15
α-helix	152-155	4
α-helix	161-169	9
α-helix	170-172	3
α-helix	176-192	17
α-helix	194-213	20
α-helix	221-232	12
α-helix	241-246	6
α-helix	247-251	5
α-helix	253-255	3
α-helix	260-277	18
α-helix	279-281	3
α-helix	282-291	10
α-helix	301-312	12
α-helix	317-320	4
α-helix	324-335	12
α-helix	340-347	8
α-helix	348-351	4
α-helix	353-360	8
α-helix	363-370	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	A	protein	352	Homo sapiens	Q13362 (AlphaFold model)
BRCA2	B	protein	13	Homo sapiens

Sequence of entity 1 (A), FASTA

>9GNJ_1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (chains A)
GIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVIT
EPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESP
DFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIF
YRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLA
YCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLF
RQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKT

Sequence of entity 2 (B), FASTA

>9GNJ_2 BRCA2 (chains B)
TELSTILEESGSQ

Primary citation

Crystal structure of a PP2A B56gamma double phosphorylated BRCA2 complex. Miron, S., Zinn-Justin, S. To be published.

Other PDB entries of the same protein (UniProt Q13362 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5JJA 2.35 Å, Crystal structure of a PP2A B56gamma/BubR1 complex
6VRO 2.45 Å, The structure of the PP2A B56 subunit AIM1 complex
2JAK 2.6 Å, Human PP2A regulatory subunit B56g
3FGA 2.7 Å, Structural Basis of PP2A and Sgo interaction
5K6S 2.79 Å, The structure of the PP2A B56 subunit BubR1 complex
5SWF 2.82 Å, The structure of the PP2A B56 subunit double phosphorylated BubR1 complex
5SW9 2.85 Å, The structure of the PP2A B56 subunit RepoMan complex
7OUF 3.0 Å, Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450
7OUG 3.1 Å, STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir
6OYL 3.15 Å, The structure of the PP2A B56 subunit KIF4A complex
6TOQ 3.16 Å, Crystal structure of a PP2A B56y/HTLV-1 integrase complex
9MF5 3.2 Å, CryoEM structure of the Protein Phosphatase 2A (Abeta-B56gamma-Calpha) holoenzyme complex

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