9MLC: DNA-directed RNA polymerase II subunit RPB1

Name: PDB 9MLC: Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome activated elongation complex Composite map T
Published: 2026-01-21
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome activated elongation complex Composite map T. Determined by electron microscopy at 2.4 Å resolution. Released 21 Jan 2026.

Method: Electron microscopy
Resolution: 2.4 Å
Organisms: Sus scrofa, Homo sapiens, synthetic construct
Chains: 27
Atoms: 60,473
Mol. weight: 1593.95 kDa
Ligands: MG, ZN
Released: 21 Jan 2026

Explore 9MLC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9MLC contains 437 α-helices and 399 β-strands across 24 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 83 helices, 75 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	20-25	6	2
α-helix	28-34	7
β-strand	43	1	3
β-strand	47-48	2	4
β-strand	51-52	2	4
α-helix	53	1
β-strand	56	1	3
β-strand	86-95	10	5
α-helix	100-109	10
β-strand	110	1	6
β-strand	117	1	6
α-helix	124-132	9
α-helix	137-148	12
β-strand	153-154	2	7
β-strand	184-187	4	7
α-helix	188-189	2
β-strand	190-194	5	8
β-strand	197-201	5	8
β-strand	213-216	4	8
α-helix	218-227	10
α-helix	230-235	6
α-helix	245-248	4
β-strand	249-255	7	5
α-helix	258-260	3
α-helix	262-263	2
β-strand	264	1	9
α-helix	265	1
β-strand	272	1	9
α-helix	275-295	21
α-helix	300-318	19
α-helix	326-328	3
β-strand	329	1	10
α-helix	334	1
β-strand	335	1	10
α-helix	336	1
α-helix	339-343	5
α-helix	349-355	7
β-strand	357-359	3	11
β-strand	362-369	8	12
β-strand	377-381	5	12
α-helix	382-387	6
β-strand	389-393	5	13
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	13
β-strand	426-428	3	13
α-helix	429-431	3
α-helix	435-438	4
β-strand	445-449	5	13
α-helix	450	1
β-strand	455-459	5	12
α-helix	466-468	3
β-strand	469-477	9	12
β-strand	482-484	3	12
α-helix	486-488	3
α-helix	489-492	4
β-strand	500-504	5	12
α-helix	509-518	10
β-strand	520	1	12
α-helix	521-524	4
β-strand	526-527	2	14
β-strand	532-533	2	14
α-helix	539-548	10
β-strand	554-555	2	15
α-helix	557-564	8
α-helix	573-574	2
β-strand	575	1	16
α-helix	576-577	2
β-strand	579	1	17
β-strand	585	1	17
β-strand	586-587	2	15
α-helix	588-595	8
β-strand	602-605	4	18
α-helix	611-613	3
β-strand	627-631	5	18
β-strand	634-637	4	18
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-679	18
β-strand	686	1	19
α-helix	689-692	4
α-helix	693-695	3
α-helix	696-721	26
α-helix	733-757	25
α-helix	765-771	7
α-helix	778-785	8
β-strand	789-790	2	20
β-strand	792-793	2	21
β-strand	796-797	2	21
α-helix	799	1
β-strand	802	1	22
β-strand	805	1	22
α-helix	811	1
β-strand	822-823	2	20
α-helix	833-852	20
α-helix	854-868	15
β-strand	872-873	2	23
β-strand	879-880	2	23
β-strand	886-888	3	23
α-helix	891-893	3
β-strand	896	1	24
α-helix	898-900	3
β-strand	902-905	4	25
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	26
α-helix	936-944	9
α-helix	946-969	24
β-strand	976-979	4	25
α-helix	983-993	11
β-strand	1002	1	26
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1056	6
α-helix	1062-1078	17
β-strand	1080	1	24
α-helix	1081-1082	2
α-helix	1087-1101	15
α-helix	1120-1128	9
β-strand	1139-1142	4	27
β-strand	1143	1	28
α-helix	1146-1148	3
α-helix	1151-1161	11
β-strand	1164-1165	2	29
α-helix	1166-1169	4
β-strand	1170-1177	8	30
α-helix	1192-1196	5
α-helix	1204-1206	3
β-strand	1210-1216	7	30
α-helix	1218-1223	6
α-helix	1228-1239	12
β-strand	1243	1	31
β-strand	1246-1247	2	30
β-strand	1256-1260	5	30
β-strand	1261	1	31
α-helix	1281-1295	15
β-strand	1297-1299	3	29
β-strand	1306-1310	5	27
α-helix	1315-1317	3
β-strand	1319-1322	4	32
β-strand	1328-1331	4	32
β-strand	1335-1339	5	27
α-helix	1343-1347	5
β-strand	1352	1	28
β-strand	1358-1359	2	27
α-helix	1362-1387	26
α-helix	1395-1406	12
α-helix	1416-1419	4
α-helix	1426-1430	5
α-helix	1437-1445	9
β-strand	1448-1449	2	2
α-helix	1454-1459	6
α-helix	1462-1464	3
α-helix	1467-1469	3
β-strand	1471-1475	5	33
α-helix	1479-1481	3

Chain B: 64 helices, 79 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-68	4	34
β-strand	83-93	11	34
α-helix	94	1
α-helix	96	1
β-strand	97-99	3	35
β-strand	105-107	3	35
α-helix	110-116	7
β-strand	121-134	14	34
α-helix	135-137	3
β-strand	138-153	16	34
α-helix	168-173	6
β-strand	185-187	3	36
β-strand	190-194	5	36
β-strand	196-200	5	37
α-helix	201	1
β-strand	205-208	4	38
β-strand	215-223	9	38
α-helix	231-232	2
β-strand	233-240	8	38
β-strand	256-259	4	38
β-strand	267-268	2	38
α-helix	269-275	7
α-helix	281-285	5
α-helix	295-307	13
α-helix	308-310	3
α-helix	314-325	12
α-helix	327	1
α-helix	332-341	10
α-helix	342-346	5
α-helix	349-351	3
α-helix	358-376	19
α-helix	381-383	3
α-helix	388-390	3
β-strand	391-394	4	37
α-helix	396-423	28
α-helix	431-434	4
α-helix	438-450	13
β-strand	453	1	39
α-helix	456-458	3
β-strand	463	1	39
α-helix	464	1
β-strand	467-469	3	36
α-helix	470-471	2
α-helix	475-482	8
β-strand	484-486	3	37
α-helix	497-499	3
α-helix	503-505	3
β-strand	509	1	40
β-strand	523-525	3	37
β-strand	526	1	40
β-strand	531-532	2	41
α-helix	539-547	9
α-helix	550	1
β-strand	551-552	2	42
β-strand	565-569	5	42
β-strand	572-577	6	42
α-helix	580-593	14
β-strand	602-606	5	42
β-strand	611-615	5	42
β-strand	621-627	7	41
β-strand	628	1	43
β-strand	633	1	43
α-helix	637-644	8
β-strand	646	1	44
β-strand	649	1	44
α-helix	653-658	6
β-strand	662-666	5	41
α-helix	669-671	3
β-strand	675-676	2	41
β-strand	695-696	2	41
α-helix	700-703	4
α-helix	708-710	3
α-helix	714-716	3
β-strand	717	1	45
α-helix	719-728	10
α-helix	729-731	3
β-strand	732	1	46
β-strand	734	1	47
α-helix	740-742	3
β-strand	747-751	5	47
β-strand	759-760	2	48
α-helix	762-765	4
β-strand	776-782	7	49
β-strand	783	1	19
β-strand	794-797	4	49
α-helix	798-802	5
β-strand	808-817	10	47
β-strand	819-820	2	50
β-strand	826-829	4	50
β-strand	837-838	2	50
α-helix	845-847	3
β-strand	853	1	51
β-strand	859-861	3	47
β-strand	865-867	3	51
β-strand	869-872	4	50
β-strand	889-891	3	50
β-strand	894-895	2	51
α-helix	896-897	2
β-strand	901-911	11	47
β-strand	917-927	11	47
β-strand	934-936	3	52
β-strand	942-944	3	52
β-strand	945-949	5	49
β-strand	956	1	53
β-strand	965-967	3	49
α-helix	969-971	3
β-strand	977	1	45
α-helix	978-993	16
β-strand	996-998	3	48
α-helix	1008-1017	10
β-strand	1025-1026	2	49
α-helix	1028	1
β-strand	1029	1	53
α-helix	1030	1
α-helix	1035	1
β-strand	1036	1	53
α-helix	1037	1
β-strand	1041-1048	8	49
β-strand	1049-1050	2	52
β-strand	1051	1	46
α-helix	1055-1057	3
β-strand	1060-1061	2	12
β-strand	1067	1	54
β-strand	1074	1	54
α-helix	1075	1
α-helix	1078-1080	3
α-helix	1082-1083	2
β-strand	1084-1086	3	11
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1113-1119	7	1
β-strand	1125	1	1
β-strand	1127-1129	3	55
β-strand	1134-1136	3	55
β-strand	1146-1152	7	1
α-helix	1153-1164	12
β-strand	1167-1172	6	2

Chain C: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	56
β-strand	18-24	7	56
α-helix	28-40	13
β-strand	43-55	13	57
α-helix	61-70	10
β-strand	73	1	58
α-helix	83-84	2
β-strand	99-106	8	57
α-helix	112	1
β-strand	113-116	4	59
α-helix	117-119	3
β-strand	121-122	2	57
β-strand	129	1	58
α-helix	146-148	3
β-strand	149-153	5	59
β-strand	158-169	12	57
α-helix	174-176	3
β-strand	179-186	8	56
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	228-235	8	56
α-helix	241-269	29

Chain D: 8 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	60
β-strand	21	1	60
β-strand	30-31	2	33
α-helix	34-48	15
α-helix	54-58	5
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-135	12

Chain E: 13 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	3-23	21
β-strand	26	1	61
α-helix	30-34	5
α-helix	37-44	8
β-strand	60-63	4	62
β-strand	64	1	61
β-strand	71-75	5	62
β-strand	81	1	63
α-helix	84-95	12
β-strand	101-106	6	62
β-strand	108	1	63
α-helix	109-111	3
α-helix	112-120	9
β-strand	126-131	6	62
α-helix	132-135	4
α-helix	139-141	3
β-strand	147-150	4	64
α-helix	151-152	2
α-helix	153-163	11
α-helix	167-169	3
β-strand	172-173	2	64
α-helix	178-183	6
α-helix	185-186	2
β-strand	190-197	8	64
β-strand	201-209	9	64

Chain F: 5 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	65
α-helix	57-58	2
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-98	10
β-strand	104-109	6	33
β-strand	115-119	5	33
β-strand	124	1	65
α-helix	125	1

Chain G: 4 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	33
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	33
β-strand	43-54	12	33
β-strand	57-59	3	33
α-helix	60	1
β-strand	66-77	12	33
β-strand	84-93	10	66
β-strand	96-101	6	66
β-strand	104-109	6	66
α-helix	110-112	3
β-strand	117-120	4	67
β-strand	127-130	4	67
β-strand	136-138	3	67
β-strand	142-153	12	66
β-strand	156-162	7	66
β-strand	169-170	2	66

Chain H: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	17
β-strand	25-32	8	17
β-strand	38-44	7	17
β-strand	55-61	7	17
β-strand	65	1	68
α-helix	69-71	3
β-strand	74	1	16
β-strand	83	1	68
α-helix	84-87	4
β-strand	90-101	12	17
β-strand	111-119	9	17
β-strand	121-128	8	17
α-helix	129-132	4
β-strand	140-147	8	17

16 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1984	Sus scrofa
DNA-directed RNA polymerase subunit beta	B	protein	1300	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	A0A481DF93 (AlphaFold model)
RPOL4c domain-containing protein	D	protein	184	Sus scrofa	A0A8D1GCS3 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	A0A4X1VTX4 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	A0A8D1AQR7
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
RNA polymerase II subunit J	K	protein	117	Sus scrofa	A0A8D0TE17
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6

15 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9MLC_1 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMQLETNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPT
SPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSY
SPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTS
PKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDS
DEEN

Sequence of entity 2 (B), FASTA

>9MLC_2 DNA-directed RNA polymerase subunit beta (chains B)
MKPLRPENPPKAELKGLLFVQQHCKTRLHSVAVTRPRGAATEESTPKLRMCSTNLSQALA
YFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLAVSCVSLRGLGA
PGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMS
VQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEAR
LRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCEL
NECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTST
IWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
FASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISV
GSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM
DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQ
DLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP
DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPA
GINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTR
ETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCST
FLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDM
PFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNL
LSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQP
MEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHT
YECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>9MLC_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>9MLC_4 RPOL4c domain-containing protein (chains D)
MWGPAQPYSDSALSPKPRPFRAVFRGSALPFPAVRVEVRGRSMAAGGSDPRAGDVEEDAS
QLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRE
TIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKR
SFQY

Sequence of entity 5 (E), FASTA

>9MLC_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>9MLC_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>9MLC_7 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>9MLC_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>9MLC_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>9MLC_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>9MLC_11 RNA polymerase II subunit J (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>9MLC_12 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	10

Primary citation

Structure and function of IWS1 in transcription elongation. Syau, D., Steinruecke, F., Roth, S. et al. Nucleic Acids Res (2026) 54. DOI 10.1093/nar/gkag357 · PubMed

Other PDB entries of the same protein (UniProt I3LGP4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9BZ0 1.9 Å, Structure of an STK19-containing TC-NER complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…
7B7U 2.8 Å, Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2

Browse structure collections

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