9MLU: FbaA with Factor H 6-7 domain

FbaA with Factor H 6-7 domain. Determined by X-ray diffraction at 1.82 Å resolution. Released 4 Feb 2026.

Method: X-ray diffraction
Resolution: 1.82 Å
Organisms: Homo sapiens, Streptococcus pyogenes
Chains: 4
Atoms: 3,376
Mol. weight: 47.38 kDa
Released: 4 Feb 2026

Explore 9MLU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9MLU contains 20 α-helices and 30 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 5 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	325	1	1
β-strand	333-335	3	2
α-helix	338-341	4
α-helix	342-344	3
β-strand	347	1	1
β-strand	352-357	6	2
β-strand	361-362	2	3
β-strand	369-375	7	2
β-strand	378-380	3	2
β-strand	386-387	2	3
β-strand	388-390	3	4
α-helix	391-393	3
β-strand	397	1	5
β-strand	405-407	3	4
β-strand	411-413	3	6
β-strand	416	1	5
α-helix	417	1
α-helix	423-425	3
β-strand	428-432	5	6
β-strand	435-437	3	6

Chain C: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	73-86	14
α-helix	91-103	13
α-helix	107-113	7
α-helix	114-118	5
α-helix	119-122	4

Chain D: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	73-86	14
α-helix	91-103	13
α-helix	107-112	6
α-helix	113-118	6
α-helix	119-123	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Complement factor H	A, B	protein	125	Homo sapiens	P08603 (AlphaFold model)
Fibronectin-binding protein	C, D	protein	78	Streptococcus pyogenes	Q93RI1 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9MLU_1 Complement factor H (chains A, B)
MGTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG
WSPAVPCLRKCYFPYLENGYNQNYGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSP
TPRCI

Sequence of entity 2 (C, D), FASTA

>9MLU_2 Fibronectin-binding protein (chains C, D)
GPGSNWHHIDKDGLIPLGISLEAAKEEFKKEVEESRLSEAQKETYKQKIKTAPDKDKLLF
TYHSEYMTAVKDLPASTE

Primary citation

Structural mechanisms for the recruitment of factor H by Streptococcus pyogenes. Kumar, A., Wang, K.C., Ghosh, P. Structure (2026) 34:778. DOI 10.1016/j.str.2026.02.010 · PubMed

Other PDB entries of the same protein (UniProt P08603 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4K12 1.08 Å, Structural Basis for Host Specificity of Factor H Binding by Streptococcus pneumoniae
3R62 1.52 Å, Structure of complement regulator Factor H mutant, T1184R.
3KZJ 1.65 Å, Structure of complement Factor H variant R1203A
2G7I 1.75 Å, Structure of Human Complement Factor H Carboxyl Terminal Domains 19-20: a Basis for…
3SW0 1.8 Å, Structure of the C-terminal region (modules 18-20) of complement regulator Factor H
6ATG 1.8 Å, Insights to complement factor H recruitment by the borrelial CspZ protein as revealed by…
9MMX 1.9 Å, M6 protein with Factor H 6-7 domain
3KXV 2.0 Å, Structure of complement Factor H variant Q1139A
3OXU 2.1 Å, Complement components factor H CCP19-20 and C3d in complex
4ONT 2.15 Å, Ternary host recognition complex of complement factor H, C3d, and sialic acid
6ZH1 2.2 Å, Crystal structure of complex between FH19-20 and FhbA protein from Borrelia hermsii
4ZH1 2.24 Å, Complement factor H in complex with the GM1 glycan

Browse structure collections

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