9P9H: Transcription factor BTF3

In situ human unrotated hibernating with CCDC124 state 80S ribosome. Determined by electron microscopy at 2.84 Å resolution. Released 24 Dec 2025.

Method
Electron microscopy
Resolution
2.84 Å
Organism
Homo sapiens
Chains
85
Atoms
225,614
Mol. weight
3343.54 kDa
Ligands
ZN, SPD, SPM, MG
Released
24 Dec 2025

Explore 9P9H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9P9H contains 607 α-helices and 610 β-strands across 80 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain CB: 45 helices, 43 β-strands

ElementResiduesLengthSheet
α-helix6-138
α-helix16-183
β-strand19-25733
α-helix32-4211
α-helix61-666
β-strand73-79733
α-helix83-864
β-strand98-104733
α-helix109-1113
α-helix112-12110
β-strand124-130733
α-helix137-14812
β-strand152-158733
α-helix160-1612
α-helix162-1665
α-helix171-19222
β-strand212-213233
β-strand214-216334
β-strand221-223334
α-helix225-23511
α-helix248-26013
β-strand265-266235
β-strand273-274235
β-strand278136
α-helix2831
β-strand284136
α-helix285-2862
β-strand287135
α-helix288-2892
α-helix290-2945
α-helix295-30612
α-helix309-31810
α-helix333-34311
β-strand345134
α-helix346-35712
α-helix359-3602
α-helix361-37212
β-strand373137
α-helix380-3878
β-strand395-403938
β-strand410-418938
β-strand421-422239
β-strand426-430538
β-strand443-446438
β-strand449-453538
β-strand458-461438
β-strand463-464239
β-strand469-473538
β-strand483-486438
α-helix491-4933
β-strand494137
α-helix495-4973
β-strand505-511740
α-helix514-5163
α-helix517-53014
β-strand535-538440
β-strand544-548540
α-helix551-56010
α-helix561-5655
β-strand570-573440
α-helix574-5785
β-strand580-583441
β-strand591-594442
β-strand601-608842
α-helix609-6102
α-helix613-6197
α-helix628-63912
α-helix643-6464
β-strand649-652442
α-helix654-6563
β-strand661-664442
α-helix671-6733
α-helix676-68813
β-strand697141
β-strand700-708942
α-helix718-73518
α-helix7371
β-strand738-742541
β-strand744-752943
α-helix753-7553
α-helix757-7659
β-strand769-776843
β-strand779-7891143
α-helix796-8049
β-strand809-813543
β-strand818-819241
α-helix830-84213
α-helix848-8503
Chain CE: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix10-3829
α-helix44-8037
Chain CI: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix52-6211
α-helix70-723
Chain La: 8 helices, 7 β-strands
ElementResiduesLengthSheet
α-helix3-53
α-helix7-104
α-helix42-487
α-helix65-684
β-strand72-74316
α-helix75-817
α-helix84-929
β-strand97-982124
β-strand100-102317
α-helix103-1064
β-strand110-112316
β-strand123-126417
β-strand128-129216
α-helix131-1399
β-strand143-146417
Chain LA: 10 helices, 20 β-strands
ElementResiduesLengthSheet
α-helix4-52
α-helix29-324
α-helix34-385
β-strand40-501123
α-helix511
β-strand57-64823
β-strand71-77723
β-strand79124
β-strand83125
β-strand87-91523
β-strand101-103323
α-helix104-1063
β-strand112-113226
β-strand116127
β-strand120128
β-strand122128
β-strand126127
β-strand134-140726
α-helix142-1443
β-strand145-149526
β-strand155-159526
β-strand163-165323
β-strand166126
β-strand169124
α-helix174-1763
α-helix182-1909
α-helix201-2033
β-strand224-225229
α-helix229-2302
β-strand237-238229
Chain Lb: 6 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix12-187
α-helix22-243
α-helix37-4913
α-helix54-7320
α-helix92-1009
α-helix106-11712
Chain LB: 19 helices, 20 β-strands
ElementResiduesLengthSheet
α-helix9-102
α-helix14-163
α-helix32-354
α-helix40-412
β-strand42-43244
β-strand45-591545
β-strand71-801045
α-helix82-832
β-strand84-951246
β-strand98-106946
α-helix1071
α-helix112-1165
α-helix134-1374
α-helix140-15617
β-strand159-165746
α-helix168-1703
α-helix177-1793
β-strand180-184546
β-strand185-186244
α-helix190-19910
β-strand204-205246
α-helix207-2104
β-strand216-222745
β-strand225-229547
α-helix231-2344
α-helix237-2415
β-strand270-273447
β-strand276-2881345
β-strand292-293248
β-strand297-298248
α-helix300-3034
α-helix3161
β-strand320149
β-strand324149
β-strand330-334545
β-strand344-348545
β-strand365-368445
α-helix382-3898
α-helix393-40210
Chain Lc: 4 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix10-2112
β-strand26-29450
α-helix31-4010
β-strand45-49550
α-helix54-6714
β-strand70-74550
α-helix78-858
β-strand93-98650

72 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transcription factor BTF3CIprotein31Homo sapiensP20290 (AlphaFold model)
28S rRNAL5RNA3675Homo sapiens
5S rRNAL7RNA120Homo sapiens
5.8S rRNAL8RNA156Homo sapiens
60S ribosomal protein L8LAprotein248Homo sapiensP62917 (AlphaFold model)
Large ribosomal subunit protein uL3LBprotein402Homo sapiensP39023 (AlphaFold model)
60S ribosomal protein L4LCprotein368Homo sapiensP36578 (AlphaFold model)
Large ribosomal subunit protein uL18LDprotein293Homo sapiensP46777
Large ribosomal subunit protein eL6LEprotein250Homo sapiensQ02878
60S ribosomal protein L7LFprotein225Homo sapiensP18124
60S ribosomal protein L7aLGprotein241Homo sapiensP62424
60S ribosomal protein L9LHprotein190Homo sapiensP32969

73 more molecules are not listed.

Sequence of entity 1 (CI), FASTA
>9P9H_1 Transcription factor BTF3 (chains CI)
IMNQEKLAKLQAQVRIGGKGTARRKKKVVHR
Sequence of entity 2 (L5), FASTA
>9P9H_2 28S rRNA (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCGCGGGGGACCGUCCCCCGACC
GGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCGGG
ACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGCCCCCGAGUGUUACAGCCCCCC
CGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGAGCGAGACCCGUCGCCGCGCUCUCC
CCCCUCGGGGGGGCCGGGCCACCCCUCCCACGGCGCGACCGCUCGGGGCGGACUGUCCCC
AGUGCGCCCCGGGCGGGUCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGC
GCGUCCCCCGAAGAGGGGGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUA
CCCACCCGACCCGUCUUGAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGC
UCGCACGAAAGCCGCCGUGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGU
GGGAUCCCGAGGCCUCUCCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGC
GCCGGGGAGGUGGAGCACGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUG
GGCAGGGCGAAGCCAGAGGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUC
GGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCC
UCCGAAGUUUCCCUCAGGAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCA
GUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUC
UCAAACUUUAAAUGGGUAAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGA
GUGCCUAGUGGGCCACUUUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGG
GUUAAGGCGCCCGAUGCCGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGAC
AGCAGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCC
GAAUCAACUAGCCCUGAAAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGC
CGGCAGUCGAGAGUGGACGGGAGCGGCGGCCGGAGCCCCGCGGACGCUACGCCGCGACGA
GUAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCG
CAGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUG
GAGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCG
AGCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGU
CGGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGG
UAACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGU
GAAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGC
GUCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGG
GUGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCU
CUGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGA
UAAGGAUUGGCUCUAAGGGCUGGGUCGGUCGCGGCCGGCGCCUAGCAGCCGACUUAGAAC
UGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAAGGCCCGCGG
CGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCA
AUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCG
UCAUCUAAUUAGUGACGCGCAUGAAXGGAUGAACGAGAUUCCCACUGUCCCUACCUACUA
UCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCU
GUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAACUCUGAUCGUUUUUUCA
CUGACCCGGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCC
CGGCCGCGCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGAC
UGGGGCGGUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACA
GAAACCUCCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUA
CAGACCGUGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUG
UCAGAAAAGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCG
CUUUUUGAUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUU
GGAUUGUUCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUA
GUUUUACCCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACC
GCAGGUUCAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAU
CUGUGGGAUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGC
AGCGCCGCGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCGGGGUCCGGUGCGGA
GUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGCCCCCUCGCCCGUCA
CGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGACGACCUGCUUCUGGG
UCGGGGUUUCGUACGUAGCAGAGCAGCUCCCUCGCUGCGAUCUAUUGAAAGUCAGCCCUC
GACACAAGGGUUUGU
Sequence of entity 3 (L7), FASTA
>9P9H_3 5S rRNA (chains L7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
Sequence of entity 4 (L8), FASTA
>9P9H_4 5.8S rRNA (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU
Sequence of entity 5 (LA), FASTA
>9P9H_5 60S ribosomal protein L8 (chains LA)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGRLRGT
Sequence of entity 6 (LB), FASTA
>9P9H_6 Large ribosomal subunit protein uL3 (chains LB)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 7 (LC), FASTA
>9P9H_7 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEK
Sequence of entity 8 (LD), FASTA
>9P9H_8 Large ribosomal subunit protein uL18 (chains LD)
GFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDII
CQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEG
QVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFP
GYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYK
KAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERA
Sequence of entity 9 (LE), FASTA
>9P9H_9 Large ribosomal subunit protein eL6 (chains LE)
KGKPHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGG
DKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHR
GKRVVFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFK
KKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALT
NGIYPHKLVF
Sequence of entity 10 (LF), FASTA
>9P9H_10 60S ribosomal protein L7 (chains LF)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN
Sequence of entity 11 (LG), FASTA
>9P9H_11 60S ribosomal protein L7a (chains LG)
KVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQ
ALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTT
LVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFT
QVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKL
G
Sequence of entity 12 (LH), FASTA
>9P9H_12 60S ribosomal protein L9 (chains LH)
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQA

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn6
SPDSpermidineC7 H19 N310
SPMSpermineC10 H26 N47
MGMagnesium ionMg219

Primary citation

Visualizing the translation landscape in human cells at high resolution. Zheng, W., Zhang, Y., Wang, J. et al. Nat Commun (2025) 16:10757-10757. DOI 10.1038/s41467-025-65795-9 · PubMed

Other PDB entries of the same protein (UniProt P20290 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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