Cryo-EM structure of alphaM/beta2 headpiece complex without alphaM I-domain - the consensus map from alphaM/beta2:C3d-anti-CR3-Nb headpiece complex. Determined by electron microscopy at 2.6 Å resolution. Released 29 Apr 2026.
Explore 9RM9 in 3D Show helices and sheets RCSB PDB PDBe
9RM9 contains 32 α-helices and 92 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3 | 1 | 1 |
| β-strand | 9-11 | 3 | 2 |
| β-strand | 21-24 | 4 | 3 |
| α-helix | 25 | 1 | |
| β-strand | 29-33 | 5 | 3 |
| β-strand | 40 | 1 | 4 |
| β-strand | 43 | 1 | 4 |
| β-strand | 45 | 1 | 5 |
| β-strand | 47-51 | 5 | 3 |
| β-strand | 57-59 | 3 | 3 |
| β-strand | 73 | 1 | 5 |
| β-strand | 76-80 | 5 | 6 |
| β-strand | 85-96 | 12 | 6 |
| β-strand | 101-110 | 10 | 6 |
| β-strand | 119-120 | 2 | 6 |
| β-strand | 317 | 1 | 7 |
| α-helix | 327 | 1 | |
| β-strand | 328 | 1 | 7 |
| α-helix | 329 | 1 | |
| β-strand | 338 | 1 | 8 |
| β-strand | 342-343 | 2 | 8 |
| β-strand | 348-352 | 5 | 8 |
| α-helix | 355-358 | 4 | |
| β-strand | 360 | 1 | 9 |
| β-strand | 361-365 | 5 | 8 |
| β-strand | 371-374 | 4 | 8 |
| α-helix | 376-378 | 3 | |
| β-strand | 388 | 1 | 9 |
| β-strand | 391-397 | 7 | 10 |
| β-strand | 400-407 | 8 | 10 |
| α-helix | 410-412 | 3 | |
| β-strand | 414 | 1 | 11 |
| β-strand | 415-422 | 8 | 10 |
| β-strand | 425-433 | 9 | 10 |
| β-strand | 441 | 1 | 11 |
| β-strand | 444-448 | 5 | 12 |
| β-strand | 458-467 | 10 | 12 |
| β-strand | 472 | 1 | 12 |
| β-strand | 473 | 1 | 13 |
| β-strand | 474-479 | 6 | 12 |
| β-strand | 492-495 | 4 | 12 |
| β-strand | 505 | 1 | 13 |
| β-strand | 509-513 | 5 | 14 |
| β-strand | 522-527 | 6 | 14 |
| α-helix | 530-533 | 4 | |
| β-strand | 535 | 1 | 15 |
| β-strand | 536-540 | 5 | 14 |
| β-strand | 542-543 | 2 | 16 |
| β-strand | 547-548 | 2 | 16 |
| β-strand | 554-557 | 4 | 14 |
| α-helix | 558-561 | 4 | |
| β-strand | 568 | 1 | 15 |
| β-strand | 572-576 | 5 | 2 |
| β-strand | 585-590 | 6 | 2 |
| β-strand | 593-598 | 6 | 2 |
| β-strand | 599 | 1 | 1 |
| β-strand | 602-610 | 9 | 17 |
| β-strand | 630-644 | 15 | 17 |
| β-strand | 657-665 | 9 | 18 |
| β-strand | 675-676 | 2 | 17 |
| β-strand | 683 | 1 | 18 |
| β-strand | 686-690 | 5 | 18 |
| β-strand | 695-704 | 10 | 17 |
| α-helix | 713 | 1 | |
| β-strand | 714-724 | 11 | 18 |
| α-helix | 725-727 | 3 | |
| α-helix | 733-735 | 3 | |
| β-strand | 736-737 | 2 | 17 |
| β-strand | 745-749 | 5 | 18 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 11-17 | 7 | |
| β-strand | 21-22 | 2 | 19 |
| β-strand | 24 | 1 | 20 |
| α-helix | 37-39 | 3 | |
| β-strand | 41-42 | 2 | 19 |
| α-helix | 43-47 | 5 | |
| β-strand | 56 | 1 | 20 |
| β-strand | 62-66 | 5 | 21 |
| β-strand | 76-77 | 2 | 22 |
| β-strand | 80-85 | 6 | 21 |
| β-strand | 86 | 1 | 23 |
| β-strand | 87 | 1 | 22 |
| β-strand | 89 | 1 | 23 |
| α-helix | 90 | 1 | |
| β-strand | 91-97 | 7 | 22 |
| β-strand | 99 | 1 | 24 |
| α-helix | 102-104 | 3 | |
| β-strand | 105-112 | 8 | 25 |
| α-helix | 115-117 | 3 | |
| α-helix | 121-138 | 18 | |
| β-strand | 142-149 | 8 | 25 |
| α-helix | 177-179 | 3 | |
| β-strand | 183-189 | 7 | 25 |
| α-helix | 192-200 | 9 | |
| α-helix | 202-204 | 3 | |
| β-strand | 212 | 1 | 26 |
| α-helix | 214-223 | 10 | |
| α-helix | 225-228 | 4 | |
| β-strand | 234-241 | 8 | 25 |
| β-strand | 245 | 1 | 26 |
| α-helix | 250-254 | 5 | |
| α-helix | 259-260 | 2 | |
| β-strand | 266 | 1 | 27 |
| β-strand | 270 | 1 | 25 |
| β-strand | 271 | 1 | 27 |
| α-helix | 272-276 | 5 | |
| α-helix | 278-281 | 4 | |
| α-helix | 282-292 | 11 | |
| β-strand | 294-300 | 7 | 25 |
| α-helix | 302-304 | 3 | |
| α-helix | 305-314 | 10 | |
| β-strand | 320-322 | 3 | 25 |
| α-helix | 328-339 | 12 | |
| β-strand | 344-349 | 6 | 21 |
| β-strand | 356-363 | 8 | 22 |
| β-strand | 369 | 1 | 22 |
| β-strand | 373 | 1 | 22 |
| β-strand | 376-379 | 4 | 21 |
| β-strand | 383 | 1 | 24 |
| β-strand | 387-395 | 9 | 22 |
| β-strand | 402-408 | 7 | 21 |
| β-strand | 414-421 | 8 | 21 |
| β-strand | 437 | 1 | 28 |
| β-strand | 440 | 1 | 28 |
| α-helix | 444-446 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Isoform 2 of Integrin alpha-M | A | protein | 763 | Homo sapiens | P11215 (AlphaFold model) |
| Integrin beta-2 | B | protein | 469 | Homo sapiens | P05107 (AlphaFold model) |
>9RM9_1 Isoform 2 of Integrin alpha-M (chains A) FNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPI RLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQK FPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEF RIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVI TDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVN NFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAG GVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFR QNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPL PRGQRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLF HGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQ PVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVT YDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNF SLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNTGGENLYFQ
>9RM9_2 Integrin beta-2 (chains B) QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPT SLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDD LRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPF AFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFA TDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAV TSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAYNKLSSRVFLDHNALPDTLKVTY DSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVL PQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCEPAAENLYFQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 5 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 3 |
| MN | Manganese (II) ion | Mn | 1 |
Three cryo-EM structures of complement C3d-bound alpha M beta 2 reveal an unexpected layer of dynamics for alpha I-containing integrin receptors. Lorentzen, J., Fruergaard, M.U., Lukacsi, S. et al. Sci Adv (2026) 12:eaea7241-eaea7241. DOI 10.1126/sciadv.aea7241 · PubMed
Other PDB entries of the same protein (UniProt P11215 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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