9SMX: CM1-activated gTuRC
CM1-activated gTuRC in complex with nascent alpha-E254D mutant microtubules. Determined by electron microscopy at 3.67 Å resolution. Released 13 May 2026.
- Method
- Electron microscopy
- Resolution
- 3.67 Å
- Organisms
- Homo sapiens, Saccharomyces cerevisiae S288C
- Chains
- 73
- Atoms
- 204,937
- Mol. weight
- 4442.41 kDa
- Ligands
- GTP
- Released
- 13 May 2026
Explore 9SMX in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9SMX contains 1,416 α-helices and 722 β-strands across 73 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 3: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-20 | 12 | |
| α-helix | 29-41 | 13 | |
| α-helix | 51-64 | 14 | |
| α-helix | 68-82 | 15 | |
| α-helix | 92-99 | 8 | |
Chain 4: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-35 | 19 | |
| α-helix | 41-53 | 13 | |
| α-helix | 57-72 | 16 | |
Chain 5: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 66-79 | 14 | |
| α-helix | 83-96 | 14 | |
| α-helix | 106-112 | 7 | |
Chain 6: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-35 | 22 | |
| α-helix | 41-51 | 11 | |
| α-helix | 57-70 | 14 | |
Chain 7: 26 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-7 | 3 | |
| β-strand | 8-11 | 4 | 18 |
| β-strand | 17-21 | 5 | 18 |
| β-strand | 29-31 | 3 | 18 |
| β-strand | 35-36 | 2 | 19 |
| β-strand | 54 | 1 | 19 |
| α-helix | 57-60 | 4 | |
| α-helix | 61-63 | 3 | |
| β-strand | 67-68 | 2 | 19 |
| β-strand | 71 | 1 | 20 |
| β-strand | 76 | 1 | 20 |
| α-helix | 79-88 | 10 | |
| α-helix | 89-93 | 5 | |
| β-strand | 103-107 | 5 | 18 |
| α-helix | 108 | 1 | |
| α-helix | 113-125 | 13 | |
| β-strand | 131-136 | 6 | 18 |
| α-helix | 137-145 | 9 | |
| β-strand | 150-155 | 6 | 21 |
| β-strand | 160-166 | 7 | 21 |
| β-strand | 169-170 | 2 | 21 |
| β-strand | 176-177 | 2 | 21 |
| α-helix | 182-196 | 15 | |
| α-helix | 199-201 | 3 | |
| α-helix | 205-216 | 12 | |
| α-helix | 223-231 | 9 | |
| α-helix | 234-237 | 4 | |
| β-strand | 239-241 | 3 | 22 |
| β-strand | 247-249 | 3 | 22 |
| α-helix | 253-256 | 4 | |
| α-helix | 257-261 | 5 | |
| α-helix | 274-284 | 11 | |
| α-helix | 287-289 | 3 | |
| α-helix | 290-295 | 6 | |
| β-strand | 297-300 | 4 | 21 |
| α-helix | 302-305 | 4 | |
| α-helix | 309-317 | 9 | |
| α-helix | 335-337 | 3 | |
| α-helix | 338-348 | 11 | |
| α-helix | 350-354 | 5 | |
| β-strand | 357-358 | 2 | 18 |
| α-helix | 359-365 | 7 | |
| α-helix | 366-369 | 4 | |
| α-helix | 370-373 | 4 | |
Chain a: 28 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-10 | 7 | 48 |
| α-helix | 12-14 | 3 | |
| α-helix | 15-28 | 14 | |
| β-strand | 31 | 1 | 49 |
| α-helix | 36 | 1 | |
| β-strand | 37 | 1 | 49 |
| α-helix | 38 | 1 | |
| α-helix | 48-50 | 3 | |
| β-strand | 52-54 | 3 | 50 |
| β-strand | 60-62 | 3 | 50 |
| β-strand | 64-67 | 4 | 48 |
| α-helix | 74-77 | 4 | |
| α-helix | 81-83 | 3 | |
| α-helix | 104-105 | 2 | |
| α-helix | 106-110 | 5 | |
| α-helix | 111-113 | 3 | |
| α-helix | 115-127 | 13 | |
| β-strand | 132-137 | 6 | 48 |
| α-helix | 146-160 | 15 | |
| β-strand | 165-172 | 8 | 48 |
| α-helix | 184-197 | 14 | |
| β-strand | 201-206 | 6 | 48 |
| α-helix | 207-213 | 7 | |
| α-helix | 214-216 | 3 | |
| α-helix | 229-239 | 11 | |
| α-helix | 241-244 | 4 | |
| α-helix | 254-258 | 5 | |
| α-helix | 264-266 | 3 | |
| β-strand | 268-269 | 2 | 48 |
| β-strand | 270-273 | 4 | 51 |
| α-helix | 276-278 | 3 | |
| α-helix | 290-298 | 9 | |
| β-strand | 317-326 | 10 | 51 |
| α-helix | 330-343 | 14 | |
| β-strand | 356-361 | 6 | 51 |
| α-helix | 362-364 | 3 | |
| β-strand | 373-381 | 9 | 51 |
| α-helix | 382-384 | 3 | |
| α-helix | 385-395 | 11 | |
| α-helix | 411-414 | 4 | |
| α-helix | 419-437 | 19 | |
| α-helix | 441-443 | 3 | |
Chain A: 47 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 151-167 | 17 | |
| α-helix | 179-183 | 5 | |
| α-helix | 185-187 | 3 | |
| α-helix | 205-207 | 3 | |
| α-helix | 210-226 | 17 | |
| β-strand | 234-235 | 2 | 31 |
| α-helix | 236-237 | 2 | |
| β-strand | 246-247 | 2 | 31 |
| α-helix | 248-249 | 2 | |
| α-helix | 254-260 | 7 | |
| α-helix | 264-280 | 17 | |
| α-helix | 283-285 | 3 | |
| α-helix | 286-304 | 19 | |
| α-helix | 321-327 | 7 | |
| α-helix | 329-347 | 19 | |
| α-helix | 353-365 | 13 | |
| α-helix | 372-383 | 12 | |
| α-helix | 391-394 | 4 | |
| β-strand | 409-410 | 2 | 32 |
| α-helix | 422-424 | 3 | |
| α-helix | 428-431 | 4 | |
| β-strand | 433-434 | 2 | 32 |
| α-helix | 436-438 | 3 | |
| α-helix | 441-446 | 6 | |
| α-helix | 447-457 | 11 | |
| α-helix | 483-505 | 23 | |
| α-helix | 509-520 | 12 | |
| α-helix | 527-539 | 13 | |
| β-strand | 542 | 1 | 33 |
| α-helix | 550-560 | 11 | |
| α-helix | 563-566 | 4 | |
| α-helix | 570-572 | 3 | |
| β-strand | 573-577 | 5 | 34 |
| β-strand | 611 | 1 | 33 |
| β-strand | 616-620 | 5 | 34 |
| α-helix | 624-627 | 4 | |
| α-helix | 632-635 | 4 | |
| α-helix | 636-638 | 3 | |
| α-helix | 641-661 | 21 | |
| α-helix | 664-668 | 5 | |
| α-helix | 676-697 | 22 | |
| α-helix | 698-702 | 5 | |
| α-helix | 703-714 | 12 | |
| α-helix | 719-736 | 18 | |
| α-helix | 738-740 | 3 | |
| α-helix | 748 | 1 | |
| α-helix | 749-753 | 5 | |
| α-helix | 754-774 | 21 | |
| α-helix | 809-838 | 30 | |
| α-helix | 839-843 | 5 | |
| α-helix | 844-846 | 3 | |
| α-helix | 852-855 | 4 | |
| α-helix | 856-859 | 4 | |
| α-helix | 866-870 | 5 | |
| α-helix | 873-876 | 4 | |
Chain AC: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 62-89 | 28 | |
64 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Gamma-tubulin complex component 3 | 3, B, D, F, H, N | protein | 907 | Homo sapiens | Q96CW5 (AlphaFold model) |
| Mitotic-spindle organizing protein 1 | 4, 6, Y | protein | 82 | Homo sapiens | Q08AG7 (AlphaFold model) |
| Gamma-tubulin complex component 6 | 5, L | protein | 1819 | Homo sapiens | Q96RT7 (AlphaFold model) |
| Actin, cytoplasmic 2, N-terminally processed | 7 | protein | 374 | Homo sapiens | P63261 (AlphaFold model) |
| Gamma-tubulin complex component 2 | A, C, CN, E, EN, G, GN, M | protein | 902 | Homo sapiens | Q9BSJ2 |
| Ubiquitin-like protein SMT3,CDK5 regulatory subunit-associated protein 2,Microtubule-associated… | AC, CC, Cc, EC, Ec, GC, Gc, MC, Mc | protein | 229 | Saccharomyces cerevisiae S288C, Homo sapiens | Q12306, Q15691, Q96SN8 |
| Isoform 1 of Tubulin alpha-1B chain | BA, CA, DA, EA, FA, GA, HA, IA, JA, KA, LA | protein | 451 | Homo sapiens | P68363 |
| Tubulin beta-3 chain | BB, CB, DB, EB, FB, GB, HB, IB, JB, KB, LB | protein | 451 | Homo sapiens | Q13509 |
| Mitotic-spindle organizing protein 2A | CM, EM, GM, MM | protein | 158 | Homo sapiens | Q6P582 |
| Gamma-tubulin complex component 4 | I, K | protein | 667 | Homo sapiens | Q9UGJ1 |
| Gamma-tubulin complex component 5 | J, Z | protein | 1024 | Homo sapiens | Q96RT8 |
| Tubulin gamma-1 chain | a, b, c, d, e, f, g, h, i, j, k, l, m, n | protein | 451 | Homo sapiens | P23258 |
Sequence of entity 1 (3, B, D, F, H, N), FASTA
>9SMX_1 Gamma-tubulin complex component 3 (chains 3, B, D, F, H, N)
MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQ
ALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSL
LPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTG
GTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWL
HNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLES
SLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILS
LVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQS
RKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFE
TSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGI
LETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHY
LRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQY
YITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFD
QIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESI
PKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTR
GRRSSHT
Sequence of entity 2 (4, 6, Y), FASTA
>9SMX_2 Mitotic-spindle organizing protein 1 (chains 4, 6, Y)
MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEAL
SSVIKELRKATEALKAAENMTS
Sequence of entity 3 (5, L), FASTA
>9SMX_3 Gamma-tubulin complex component 6 (chains 5, L)
MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD
MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS
GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ
VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD
LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV
GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL
IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD
SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG
AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV
YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK
TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE
KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR
QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW
RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG
QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL
PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA
VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ
PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH
GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA
SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE
SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV
STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR
LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL
SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE
PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN
KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS
VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC
VSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI
QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI
FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ
PHLEDFLLRINFNNYYQDA
Sequence of entity 4 (7), FASTA
>9SMX_4 Actin, cytoplasmic 2, N-terminally processed (chains 7)
DEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSK
RGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQ
IMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLA
GRDLTDYLMKILTERGYSFTTTEEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYE
LKDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSG
GTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQE
YDESGPSIVHRKCF
Sequence of entity 5 (A, C, CN, E, EN, G, GN, M), FASTA
>9SMX_5 Gamma-tubulin complex component 2 (chains A, C, CN, E, EN, G, GN, M)
MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTP
EDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQYLQQNAKERAELAAAAVGSSTTSI
NVPAAASKISMQELEELRKQLGSVATGSTLQQSLELKRKMLRDKQNKKNSGQHLPIFPAW
VYERPALIGDFLIGAGISTDTALPIGTLPLASQESAVVEDLLYVLVGVDGRYVSAQPLAG
RQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLV
KEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGECLGGSTLSLLH
DRSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQ
EDYNDKYWDQRYTIVQQQIPSFLQKMADKILSTGKYLNVVRECGHDVTCPVAKEIIYTLK
ERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLAEEELR
KPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAM
AHADPTELALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWI
SNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNID
DVLGHHTGFLDTCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGELGGQTL
EHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLARL
SIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKATPQVPVLRGPPAPAPRVAVT
AQ
Sequence of entity 6 (AC, CC, Cc, EC, Ec, GC, Gc, MC, Mc), FASTA
>9SMX_6 Ubiquitin-like protein SMT3,CDK5 regulatory subunit-associated protein 2,Microtubule-associated protein RP/EB family member 1 (chains AC, CC, Cc, EC, Ec, GC, Gc, MC, Mc)
MGSSHHHHHHGSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLME
AFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGAWSHPQFEKSAT
VSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGDDEAAELMQQVNVLKLT
VEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVI
Sequence of entity 7 (BA, CA, DA, EA, FA, GA, HA, IA, JA, KA, LA), FASTA
>9SMX_7 Isoform 1 of Tubulin alpha-1B chain (chains BA, CA, DA, EA, FA, GA, HA, IA, JA, KA, LA)
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTDFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
Sequence of entity 8 (BB, CB, DB, EB, FB, GB, HB, IB, JB, KB, LB), FASTA
>9SMX_8 Tubulin beta-3 chain (chains BB, CB, DB, EB, FB, GB, HB, IB, JB, KB, LB)
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPKG
Sequence of entity 9 (CM, EM, GM, MM), FASTA
>9SMX_9 Mitotic-spindle organizing protein 2A (chains CM, EM, GM, MM)
MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGGIDPDVFKILV
DLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETRGRDKGSAALGGVLA
LAERSNHEGSSQRMPRQPSATRLPKGGGPGKSPTQGST
Sequence of entity 10 (I, K), FASTA
>9SMX_10 Gamma-tubulin complex component 4 (chains I, K)
MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIE
QYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSIS
HVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCH
GVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQD
LRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSIL
KNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDF
YLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEY
HGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFK
YLLSVRRVQAELQHCWALQMQRKHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQ
FSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQN
LGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGG
TLGSFGM
Sequence of entity 11 (J, Z), FASTA
>9SMX_11 Gamma-tubulin complex component 5 (chains J, Z)
MARHGPPWSRLDAQQERDVRELVRGVAGLQDEADPNFQLALNFAWSNFRFHRFLDVNSHK
IEKTIEGIYEKFVIHSDLSKAASWKRLTEEFLNAPLPSIKEIKTDAHYSILSLLLCLSDS
PSNSSYVETPRNKEVEKKDDFDWGKYLMEDEEMDIGPYMDTPNWSEESEEENDQQPLSRE
DSGIQVDRTPLEEQDQNRKLDPCISWKDEPDDRSWLEHHVVHQYWTARPSQFPHSLHLHS
NLAAVWDQHLYSSDPLYVPDDRVLVTETQVIRETLWLLSGVKKLFIFQLIDGKVTVRNNI
IVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESMLPGSGSVPKKSTEAPFRT
YQAFMWALYKYFISFKEELAEIEKCIINNDTTITLAIVVDKLAPRLSQLKVLHKVFSTGV
AEVPPDTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQTVDEWI
VHGHLWDGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQG
PSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCAESTTCQAGARDAERKSLYTLFLESV
QSRLRHGEDSTPQVLTEQQATKENLMKMQSIAESHLELDDVHDPLLAINFARMYLEQSDF
HEKFAGGDVCVDRSSESVTCQTFELTLRSCLYPHIDKQYLDCCGNLMQTLKKDYRLVEYL
QAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSIS
FENVDTAKKKLPVHILDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLDV
LLFGELVSTAEKPRLKEGLIHEQDTVAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHNY
IMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLNL
ALMFADGWQAGLGTWRMESIEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSLMAG
MEQS
Sequence of entity 12 (a, b, c, d, e, f, g, h, i, j, k, l, m, n), FASTA
>9SMX_12 Tubulin gamma-1 chain (chains a, b, c, d, e, f, g, h, i, j, k, l, m, n)
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDE
MDTSREIVQQLIDEYHAATRPDYISWGTQEQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 11 |
Primary citation
Structural basis of human gamma TuRC closure during CM1-activated microtubule nucleation. Serna, M., Brito, C., Speroni, S. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-70773-w · PubMed
Other PDB entries of the same protein (UniProt Q96CW5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8RX1 3.57 Å, CryoEM structure of the gTuRC-CM1dim complex
- 6X0U 3.6 Å, Structure of MZT1/GCP3-NHD and MZT1/GCP6-NHD in the gamma-TuRC lumenal bridge
- 8Q62 3.72 Å, Early closed conformation of the g-tubulin ring complex
- 6V6B 3.8 Å, Structures of GCP2 and GCP3 in the native human gamma-tubulin ring complex
- 7AS4 4.13 Å, Recombinant human gTuRC
- 6V6S 4.3 Å, Structure of the native human gamma-tubulin ring complex
- 9QVN 4.7 Å, Cryo-EM reconstruction of the NEDD1 anchor protein bound to the gamma-tubulin ring complex
- 7QJ0 5.32 Å, Structure of recombinant human gamma-Tubulin Ring Complex 6-spoked assembly intermediate…
- 9QVM 6.8 Å, Cryo-EM reconstruction of the NEDD1 anchor protein and CDK5RAP2 bound to the…
- 7QJ1 7.0 Å, Structure of the recombinant human gamma-Tubulin Ring Complex 6-spoked assembly…
- 8VRD 7.0 Å, Rigid body fitted model for free recombinant gamma tubulin ring complex.
- 7QJD 7.1 Å, Structure of recombinant human gamma-Tubulin Ring Complex without actin
Browse structure collections
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