Tissue inhibitor of metalloproteinase-1 (TIMP-1). Determined by X-ray diffraction at 1.95 Å resolution. Released 15 Sept 2025.
Explore 9SOP in 3D Show helices and sheets RCSB PDB PDBe
9SOP contains 23 α-helices and 23 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 5-7 | 3 | |
| α-helix | 8-14 | 7 | |
| β-strand | 17-29 | 13 | 1 |
| β-strand | 35-47 | 13 | 1 |
| α-helix | 49-52 | 4 | |
| α-helix | 53-55 | 3 | |
| β-strand | 60-64 | 5 | 1 |
| α-helix | 67-69 | 3 | |
| β-strand | 83-90 | 8 | 1 |
| β-strand | 93-95 | 3 | 1 |
| β-strand | 102-104 | 3 | 1 |
| α-helix | 105-107 | 3 | |
| α-helix | 110-114 | 5 | |
| α-helix | 115-119 | 5 | |
| α-helix | 120-123 | 4 | |
| β-strand | 128-131 | 4 | 2 |
| β-strand | 144-147 | 4 | 2 |
| α-helix | 148-151 | 4 | |
| α-helix | 155-157 | 3 | |
| α-helix | 159-163 | 5 | |
| β-strand | 164-170 | 7 | 3 |
| β-strand | 173-178 | 6 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 5-7 | 3 | |
| α-helix | 8-14 | 7 | |
| β-strand | 17-23 | 7 | 4 |
| β-strand | 28-29 | 2 | 5 |
| β-strand | 35-39 | 5 | 5 |
| β-strand | 40-47 | 8 | 4 |
| α-helix | 50-52 | 3 | |
| β-strand | 60-64 | 5 | 5 |
| α-helix | 67-69 | 3 | |
| β-strand | 83-87 | 5 | 4 |
| β-strand | 88-90 | 3 | 5 |
| β-strand | 93-95 | 3 | 5 |
| β-strand | 101-104 | 4 | 4 |
| α-helix | 105-107 | 3 | |
| α-helix | 110-114 | 5 | |
| α-helix | 115-119 | 5 | |
| α-helix | 121-124 | 4 | |
| β-strand | 128-131 | 4 | 6 |
| β-strand | 144-147 | 4 | 6 |
| α-helix | 148-151 | 4 | |
| α-helix | 155-157 | 3 | |
| α-helix | 159-163 | 5 | |
| β-strand | 164-170 | 7 | 7 |
| β-strand | 173-178 | 6 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Metalloproteinase inhibitor 1 | A, B | protein | 180 | Homo sapiens | P01033 (AlphaFold model) |
>9SOP_1 Metalloproteinase inhibitor 1 (chains A, B) CTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRF VYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTY TVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLR
Water and common crystallization additives (GOL, EDO, PGE) are not listed.
The human TIMP-1 unbound structure provides a platform for fragment screening. Shemy, A., Van Broeckhoven, J., Hellings, N. et al. Acta Crystallogr D Struct Biol (2026) 82:330-335. DOI 10.1107/S2059798326001749 · PubMed
Other PDB entries of the same protein (UniProt P01033 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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