9XC6: BMS-986187-bound MOR-Gi1 complex

Cryo-EM structure of BMS-986187-bound MOR-Gi1 complex. Determined by electron microscopy at 3.04 Å resolution. Released 8 Jul 2026.

Method: Electron microscopy
Resolution: 3.04 Å
Organisms: Oplophorus gracilirostris, Homo sapiens
Chains: 4
Atoms: 7,150
Mol. weight: 116.35 kDa
Ligands: A1D6B, A1ESG
Released: 8 Jul 2026

Explore 9XC6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9XC6 contains 35 α-helices and 38 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	7-28	22
β-strand	33-38	6	1
α-helix	46-53	8
β-strand	185-190	6	1
β-strand	195-200	6	1
α-helix	208-210	3
α-helix	212-215	4
β-strand	220-226	7	1
α-helix	227-230	4
β-strand	233-235	3	2
β-strand	239-241	3	2
α-helix	242-254	13
β-strand	263-269	7	1
α-helix	271-278	8
α-helix	283-285	3
α-helix	296-309	14
β-strand	319-322	4	1
α-helix	329-351	23

Chain B: 4 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	7-25	19
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-51	5	3
β-strand	58-63	6	4
β-strand	69-74	6	4
β-strand	78-83	6	4
β-strand	91-94	4	4
β-strand	100-105	6	5
β-strand	111-116	6	5
β-strand	121-125	5	5
β-strand	134-139	6	5
β-strand	146-151	6	6
β-strand	156-161	6	6
β-strand	165-170	6	6
β-strand	176-179	4	6
β-strand	187-192	6	7
β-strand	198-203	6	7
β-strand	207-212	6	7
β-strand	218-223	6	7
β-strand	229-234	6	8
β-strand	240-245	6	8
β-strand	249-254	6	8
β-strand	259-263	5	8
α-helix	272	1
β-strand	273-278	6	9
β-strand	284-289	6	9
β-strand	293-298	6	9
β-strand	304-308	5	9
β-strand	315-320	6	3
β-strand	327-331	5	3
β-strand	336-339	4	3

Chain C: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	10-23	14
α-helix	30-43	14
α-helix	45-47	3
α-helix	53-55	3
α-helix	56-58	3

Chain R: 16 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	70-98	29
α-helix	104-120	17
α-helix	123-132	10
α-helix	140-142	3
α-helix	149-152	4
α-helix	155-172	18
α-helix	174-180	7
α-helix	183-207	25
β-strand	208-213	6	10
β-strand	216-221	6	10
α-helix	233-239	7
α-helix	240-244	5
α-helix	245-260	16
α-helix	265-267	3
α-helix	275-307	33
α-helix	314-335	22
α-helix	336-340	5
α-helix	343-347	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Guanine nucleotide-binding protein G(i) subunit alpha-1	A	protein	353	Oplophorus gracilirostris	P63097 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	335	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	C	protein	56	Homo sapiens	P59768 (AlphaFold model)
Mu-type opioid receptor	R	protein	281	Homo sapiens	P35372 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9XC6_1 Guanine nucleotide-binding protein G(i) subunit alpha-1 (chains A)
GCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKNTIVKQMKIIHEAGY
SEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTA
ELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKT
TGIVETHFTFKDLHFKMFDVGAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMN
RMHASMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAA
YIQCQFEDLNKRKDTKEIYTHFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF

Sequence of entity 2 (B), FASTA

>9XC6_2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
QLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGT
DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYN
LKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTG
DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS
DDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRA
GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 3 (C), FASTA

>9XC6_3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains C)
IAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK

Sequence of entity 4 (R), FASTA

>9XC6_4 Mu-type opioid receptor (chains R)
TAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSV
NYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKI
INVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVL
IITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV
TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF

Ligands and cofactors

ID	Name	Formula	Copies
A1D6B	3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-4,5,7,9-tetrahydro-2~…	C31 H34 O4	1
A1ESG	Levomethadone	C21 H27 N O	1

Primary citation

Molecular mechanism of allosteric modulation of opioid receptors. Wang, H., Miao, Z., Zhao, C. et al. Signal Transduct Target Ther (2026) 11. DOI 10.1038/s41392-026-02759-5 · PubMed

Other PDB entries of the same protein (UniProt P63097 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9XDR 2.58 Å, Cryo-EM structure of asimadoline-BMS-986187-bound KOR-Gi1 complex
9J5V 2.86 Å, Human Lysophosphatidic Acid Receptor 1-Gi complex bound to CpY
6NBF 3.0 Å, Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting…
7D68 3.0 Å, Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex
9XHH 3.0 Å, Structure of the CCL19-CCR7-Gi-scFv16 complex
8X17 3.19 Å, Cryo-EM structure of adenosine receptor A3AR bound to CF102
9XHI 3.2 Å, Structure of the CCL21-CCR7-Gi-scFv16 complex
9M54 3.24 Å, Cryo-EM structure of neuropeptide FF receptor 2 complex with NPVF
8X16 3.29 Å, Cryo-EM structure of adenosine receptor A3AR bound to CF101
7EQ1 3.3 Å, GPR114-Gs-scFv16 complex
6NBH 3.5 Å, Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting…
6NBI 4.0 Å, Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting…

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