Chromodomain-helicase-DNA-binding protein 1 (CHD1) is a 1710-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O14646.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 62.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP…
Component of the SAGA complex (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB (By similarity). Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5AFW | X-ray | 1.6 Å | A=270-443 |
| 4B4C | X-ray | 1.62 Å | A=1119-1327 |
| 4O42 | X-ray | 1.87 Å | A=268-443 |
| 4NW2 | X-ray | 1.9 Å | A/C=268-443 |
| 2B2Y | X-ray | 2.35 Å | A/B=268-443, C=268-373 |
| 2B2W | X-ray | 2.4 Å | A/B=268-443, C=268-373 |
| 2B2T | X-ray | 2.45 Å | A/B=268-443, C=268-373 |
| 2B2V | X-ray | 2.65 Å | A/B=268-443, C=268-373 |
| 2B2U | X-ray | 2.95 Å | A/B=268-443, C=268-373 |
| 8UMG | X-ray | 3.1 Å | A/B/C=268-445 |
| 9EAR | EM | 3.1 Å | W=2-1327 |
| 9NH8 | EM | 3.2 Å | W=2-1327 |
| 2N39 | NMR | A=1409-1511 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.