Receptor activity-modifying protein 1 (RAMP1) is a 148-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O60894.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 89.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:33602864, PubMed:9620797, PubMed:35324283, PubMed:38603770). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB (PubMed:33602864, PubMed:9620797). Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA (PubMed:35324283, PubMed:38603770)
Heterodimer of CALCRL and RAMP1; the interaction induces allosteric modulation of CALCRL function and CGRP1/CALCA and CGRP2/CALCB ligand specificity (PubMed:18725456, PubMed:20826335, PubMed:33602864). Heterodimer of CALCR and RAMP1; interaction forms the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA ligands (PubMed:35324283, PubMed:38603770)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6ZHO | X-ray | 1.6 Å | A=24-111 |
| 8AX7 | X-ray | 1.65 Å | A=24-111 |
| 6ZIS | X-ray | 1.73 Å | A=24-111 |
| 7P0F | X-ray | 1.85 Å | A=24-111 |
| 8AX6 | X-ray | 1.9 Å | A=24-111 |
| 6D1U | X-ray | 2.05 Å | A/B/C=24-111 |
| 3N7S | X-ray | 2.1 Å | C/D=26-117 |
| 7TYF | EM | 2.2 Å | E=27-148 |
| 9BP3 | EM | 2.2 Å | E=27-148 |
| 7P0I | X-ray | 2.3 Å | A=24-111 |
| 2YX8 | X-ray | 2.4 Å | A=27-112 |
| 9AUC | EM | 2.4 Å | E=27-148 |
| 4RWG | X-ray | 2.44 Å | A/B/C=23-108 |
| 6UMG | X-ray | 2.7 Å | R/r=26-117 |
| 8AX5 | X-ray | 2.75 Å | A=24-111 |
| 3N7P | X-ray | 2.8 Å | D/E/F/R=26-117 |
| 5V6Y | X-ray | 2.8 Å | A/B/C/D=24-111 |
| 3N7R | X-ray | 2.9 Å | C/D=26-117 |
| 7TYW | EM | 3.0 Å | E=27-148 |
| 7KNT | EM | 3.15 Å | E=27-148 |
Showing 20 of 25 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.