Barrier-to-autointegration factor (BANF1) is a 89-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75531.
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The mean pLDDT of this model is 96.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 97% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:31796734, PubMed:32792394). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (PubMed:9465049). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (PubMed:28841419). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA…
Homodimer (PubMed:16337940, PubMed:22399800, PubMed:28841419). Heterodimerizes with BANF2 (PubMed:16337940). Interacts with ANKLE2/LEM4, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A) (PubMed:22770216). Binds non-specifically to double-stranded DNA, and is found as a hexamer or dodecamer upon DNA binding. Binds to LEM…
Nucleus, Chromosome, Nucleus envelope, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7NDY | X-ray | 1.44 Å | A/B=2-89 |
| 7Z21 | X-ray | 1.63 Å | A/B/C/D=2-89 |
| 6URE | X-ray | 1.65 Å | A/B=1-89 |
| 6URJ | X-ray | 1.65 Å | A/B=1-89 |
| 6URZ | X-ray | 1.65 Å | A/B=1-89 |
| 6US0 | X-ray | 1.65 Å | A/B=1-89 |
| 6US1 | X-ray | 1.65 Å | A/B=1-89 |
| 6US7 | X-ray | 1.65 Å | A/B=1-89 |
| 6USD | X-ray | 1.65 Å | A/B=1-89 |
| 6USI | X-ray | 1.65 Å | A/B=1-89 |
| 6URN | X-ray | 1.68 Å | A/B=1-89 |
| 6USB | X-ray | 1.68 Å | A/B=1-89 |
| 6URL | X-ray | 1.72 Å | A/B=1-89 |
| 6UNT | X-ray | 1.75 Å | A/B=1-89 |
| 6URR | X-ray | 1.8 Å | A/B=1-89 |
| 6URK | X-ray | 1.86 Å | A/B=1-89 |
| 1CI4 | X-ray | 1.9 Å | A/B=1-89 |
| 6GHD | X-ray | 2.1 Å | A/C/D/E=2-89 |
| 6RPR | X-ray | 2.26 Å | D/E=3-89 |
| 2BZF | X-ray | 2.87 Å | A=1-89 |
Showing 20 of 29 experimental structures (best resolution first).
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