Pre-mRNA-processing factor 6 (PRPF6) is a 941-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O94906.
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The mean pLDDT of this model is 79.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 56% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation
Identified in the spliceosome B complex (PubMed:28781166). Identified in the spliceosome C complex (PubMed:11991638). Associates with the U5 snRNP particle (PubMed:10788320). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, LSm proteins…
Nucleus, nucleoplasm, Nucleus speckle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8H6L | EM | 2.6 Å | 4G=1-941 |
| 8H6K | EM | 2.7 Å | 4G=1-941 |
| 6QW6 | EM | 2.92 Å | 5J=1-941 |
| 8Q7N | EM | 3.1 Å | N=1-941 |
| 8Q91 | EM | 3.1 Å | E=1-941 |
| 8QOZ | EM | 3.1 Å | N=1-941 |
| 8QPE | EM | 3.1 Å | N=1-941 |
| 8H6E | EM | 3.2 Å | 4G=1-941 |
| 8Q7Q | EM | 3.2 Å | F=1-941 |
| 8RC0 | EM | 3.2 Å | E=1-941 |
| 8H6J | EM | 3.25 Å | 4G=1-941 |
| 6QX9 | EM | 3.28 Å | 5J=656-937 |
| 8Y6O | EM | 3.38 Å | G=1-941 |
| 8QP8 | EM | 3.5 Å | N=1-941 |
| 8QPA | EM | 3.7 Å | N=1-941 |
| 8QPB | EM | 3.7 Å | N=1-941 |
| 6AHD | EM | 3.8 Å | N=1-941 |
| 8Q7V | EM | 3.8 Å | F=1-941 |
| 8Q7W | EM | 3.9 Å | F=1-941 |
| 8QP9 | EM | 4.1 Å | N=1-941 |
Showing 20 of 33 experimental structures (best resolution first).
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