Transcription elongation factor S-II (DST1) is a 309-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07273.
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The mean pLDDT of this model is 78.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 57% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7FAW | X-ray | 2.44 Å | A/B/C=1-73 |
| 3PO3 | X-ray | 3.3 Å | S=132-309 |
| 7UI9 | EM | 3.3 Å | S=1-309 |
| 7UIO | EM | 3.3 Å | AS/BS=1-309 |
| 8UMI | EM | 3.7 Å | S=1-309 |
| 8UOT | EM | 3.7 Å | S=1-309 |
| 1PQV | X-ray | 3.8 Å | S=1-309 |
| 1Y1V | X-ray | 3.8 Å | S=131-309 |
| 3GTM | X-ray | 3.8 Å | S=145-304 |
| 8UOQ | EM | 3.8 Å | S=1-309 |
| 1Y1Y | X-ray | 4.0 Å | S=131-309 |
| 8UMH | EM | 4.1 Å | S=1-309 |
| 7UIF | EM | 4.6 Å | S=1-309 |
| 5FMF | EM | 6.0 Å | 2=136-309 |
| 1ENW | NMR | A=131-240 | |
| 1EO0 | NMR | A=1-77 |
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