T-cell-specific surface glycoprotein CD28 (CD28) is a 220-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10747.
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The mean pLDDT of this model is 81.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 30% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets (PubMed:12196291, PubMed:1650475, PubMed:35397202). Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B…
Homodimer; disulfide-linked (PubMed:35397202). Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70 (PubMed:12196291). Interacts with GRB2 (PubMed:24098653, PubMed:7568038). Interacts with PIK3R1 (PubMed:7568038). Interacts with PRKCQ (PubMed:21964608)
Cell membrane, Cell surface
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5GJI | X-ray | 0.9 Å | B=189-196 |
| 5AUL | X-ray | 1.1 Å | B=189-196 |
| 5GJH | X-ray | 1.2 Å | B/D=189-196 |
| 3WA4 | X-ray | 1.35 Å | B=189-196 |
| 7PPN | X-ray | 1.9 Å | B=183-198 |
| 1YJD | X-ray | 2.7 Å | C=17-152 |
| 8S6Z | X-ray | 3.05 Å | C/F=19-152 |
| 6O8D | X-ray | 3.55 Å | C=19-136 |
| 7VU5 | NMR | A/B=148-188 | |
| 8W2V | NMR | A=114-152 |
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