Islet amyloid polypeptide (IAPP) is a 89-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10997.
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The mean pLDDT of this model is 78.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 67% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity)
Can form homodimers (PubMed:19475663). Interacts with IDE and INS (PubMed:17051221, PubMed:19475663). Interaction with INS inhibits homodimerization and fibril formation (PubMed:19475663)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8YG2 | X-ray | 1.25 Å | A=55-60 |
| 5KO0 | EM | 1.4 Å | A/B=48-58 |
| 3FPO | X-ray | 1.5 Å | A=51-56 |
| 3FTK | X-ray | 1.5 Å | A=64-70 |
| 3FTL | X-ray | 1.6 Å | A/B=64-70 |
| 3FTR | X-ray | 1.61 Å | A=61-66 |
| 3DG1 | X-ray | 1.66 Å | A=61-66 |
| 3G7W | X-ray | 1.75 Å | A=34-55 |
| 3FTH | X-ray | 1.84 Å | A/B=47-53 |
| 3FR1 | X-ray | 1.85 Å | A=47-52 |
| 3G7V | X-ray | 1.86 Å | A/B/C/D=34-70 |
| 9CC5 | X-ray | 1.87 Å | B=34-70 |
| 5KNZ | EM | 1.9 Å | A=52-62 |
| 8F0K | EM | 1.9 Å | P=34-70 |
| 8F0J | EM | 2.0 Å | P=34-70 |
| 8F2B | EM | 2.0 Å | P=34-70 |
| 9NZH | X-ray | 2.03 Å | B=34-70 |
| 8AZ4 | EM | 2.2 Å | A/B/C/D/E/F/G/H/I/J=34-70 |
| 8F2A | EM | 2.2 Å | P=34-70 |
| 9BP3 | EM | 2.2 Å | P=33-69 |
Showing 20 of 76 experimental structures (best resolution first).
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