DNA polymerase alpha catalytic subunit A (POL1) is a 1468-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P13382.
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The mean pLDDT of this model is 74.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 41% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) constitutes a replicative polymerase (PubMed:10898792, PubMed:22119860, PubMed:31488849). POL1 has a role in promoting telomere replication during interaction with CDC13 (PubMed:10898792)
DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A POL1 and B POL12, and the DNA primase large PRI2 and small PRI1 subunits (PubMed:3061469). Subunit B POL12 binds to subunit A POL1 (PubMed:19494830). POL1 interacts with CDC13, POB3, SPT16 and MCM10 (PubMed:10898792, PubMed:16675460,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4FVM | X-ray | 2.3 Å | A=349-1258 |
| 3OIQ | X-ray | 2.4 Å | B=215-250 |
| 3FLO | X-ray | 2.5 Å | B/D/F/H=1263-1468 |
| 4B08 | X-ray | 2.67 Å | A=349-1258 |
| 4C93 | X-ray | 2.69 Å | D/E=137-149 |
| 4FXD | X-ray | 3.0 Å | A/B=349-1258 |
| 4FYD | X-ray | 3.1 Å | A/B=349-1258 |
| 8B9A | EM | 3.5 Å | J=1-1468 |
| 8B9B | EM | 3.5 Å | J=1-1468 |
| 8FOK | EM | 3.56 Å | 1=1-1468 |
| 8FOC | EM | 3.7 Å | 1=1-1468 |
| 8FOD | EM | 3.8 Å | 1=1-1468 |
| 8B9C | EM | 4.6 Å | J=1-1468 |
| 8FOJ | EM | 4.8 Å | 1=1-1468 |
| 8FOH | EM | 4.93 Å | 1=1-1468 |
| 8FOE | EM | 5.6 Å | 1=1-1468 |
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