Crystal structure of yeast DNA polymerase alpha. Determined by X-ray diffraction at 2.3 Å resolution. Released 27 Feb 2013.
Explore 4FVM in 3D Show helices and sheets RCSB PDB PDBe
4FVM contains 41 α-helices and 33 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 352-362 | 11 | 1 |
| β-strand | 365-373 | 9 | 1 |
| β-strand | 379-386 | 8 | 1 |
| β-strand | 390-397 | 8 | 2 |
| α-helix | 403-418 | 16 | |
| β-strand | 425-431 | 7 | 2 |
| β-strand | 442-451 | 10 | 2 |
| α-helix | 460-463 | 4 | |
| β-strand | 471-475 | 5 | 2 |
| α-helix | 481-488 | 8 | |
| β-strand | 496-499 | 4 | 1 |
| β-strand | 503 | 1 | 1 |
| β-strand | 511 | 1 | 3 |
| β-strand | 515-519 | 5 | 1 |
| α-helix | 522-524 | 3 | |
| β-strand | 525-527 | 3 | 1 |
| β-strand | 536-548 | 13 | 4 |
| β-strand | 553-567 | 15 | 4 |
| α-helix | 572-574 | 3 | |
| α-helix | 577-579 | 3 | |
| β-strand | 581-586 | 6 | 4 |
| α-helix | 594-595 | 2 | |
| α-helix | 598-605 | 8 | |
| β-strand | 609-612 | 4 | 4 |
| α-helix | 616-630 | 15 | |
| β-strand | 634-637 | 4 | 4 |
| α-helix | 640-644 | 5 | |
| α-helix | 645-654 | 10 | |
| α-helix | 660-663 | 4 | |
| β-strand | 666 | 1 | 3 |
| α-helix | 682-691 | 10 | |
| β-strand | 695-698 | 4 | 4 |
| α-helix | 702-706 | 5 | |
| α-helix | 716-724 | 9 | |
| α-helix | 739-742 | 4 | |
| α-helix | 744-767 | 24 | |
| α-helix | 770-781 | 12 | |
| α-helix | 785-790 | 6 | |
| α-helix | 793-807 | 15 | |
| β-strand | 810 | 1 | 2 |
| α-helix | 811-814 | 4 | |
| β-strand | 849 | 1 | 5 |
| β-strand | 854-856 | 3 | 5 |
| β-strand | 860-864 | 5 | 5 |
| α-helix | 868-875 | 8 | |
| α-helix | 896-898 | 3 | |
| α-helix | 902-903 | 2 | |
| α-helix | 905-926 | 22 | |
| α-helix | 930-947 | 18 | |
| α-helix | 951-955 | 5 | |
| α-helix | 964-987 | 24 | |
| β-strand | 991-995 | 5 | 5 |
| β-strand | 999-1003 | 5 | 5 |
| α-helix | 1009-1026 | 18 | |
| β-strand | 1033-1045 | 13 | 5 |
| β-strand | 1048-1054 | 7 | 5 |
| β-strand | 1064-1069 | 6 | 5 |
| α-helix | 1080-1093 | 14 | |
| α-helix | 1101-1118 | 18 | |
| α-helix | 1124-1127 | 4 | |
| β-strand | 1129-1132 | 4 | 6 |
| α-helix | 1137-1139 | 3 | |
| α-helix | 1143-1145 | 3 | |
| α-helix | 1147-1158 | 12 | |
| α-helix | 1166 | 1 | |
| β-strand | 1167-1172 | 6 | 6 |
| β-strand | 1173 | 1 | 7 |
| β-strand | 1193-1195 | 3 | 6 |
| α-helix | 1196-1200 | 5 | |
| α-helix | 1202-1204 | 3 | |
| β-strand | 1208 | 1 | 7 |
| α-helix | 1210-1212 | 3 | |
| α-helix | 1213-1219 | 7 | |
| α-helix | 1220-1225 | 6 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| DNA polymerase alpha catalytic subunit A | A | protein | 910 | Saccharomyces cerevisiae | P13382 (AlphaFold model) |
>4FVM_1 DNA polymerase alpha catalytic subunit A (chains A) TDTFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREGKTPTDIHE EIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLLPYQTPKSSRDTIPSDLSS DTFYHVFGGNSNIFESFVIQNRIMGPCWLDIKGADFNSIRNASHCAVEVSVDKPQNITPT TTKTMPNLRCLSLSIQTLMNPKENKQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRP PQSTSFPLGLAALAKQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVL AHRMHDLNIPTFSSIGRRLRRTWPEKFGRGNSNMNHFFISDICSGRLICDIANEMGQSLT PKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMALQENITNCMISAEVSYRI QLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYILLHEFSRNGFIVPDKEGNRSRAQKQRQN EENADAPVNSKKAKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNKE DIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHKRVQCDIRQQALKLTAN SMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESMNLLVVYGDTDSVMIDTGCDN YADAIKIGLGFKRLVNERYRLLEIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEV KGLDMKRREFCPLSRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYK INMKLSKDPKAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKQDEIDNAADTPALS VAERAHALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALGLDSKKY FRREGGNNNG
Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha. Perera, R.L., Torella, R., Klinge, S. et al. Elife (2013) 2:e00482. DOI 10.7554/eLife.00482 · PubMed
Other PDB entries of the same protein (UniProt P13382 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 4FVM directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.