Myosin heavy chain, striated muscle is a 1938-residue protein from Argopecten irradians. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P24733.
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The mean pLDDT of this model is 73.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 53% |
| 50 to 70 | Low: treat with caution | 31% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Muscle contraction
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
Cytoplasm, myofibril
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1WDC | X-ray | 2.0 Å | A=774-837 |
| 3JVT | X-ray | 2.1 Å | A=773-837 |
| 1KK8 | X-ray | 2.3 Å | A=1-837 |
| 3BAS | X-ray | 2.3 Å | A/B=835-885 |
| 3BAT | X-ray | 2.3 Å | A/B/C/D=835-885 |
| 1B7T | X-ray | 2.5 Å | A=1-835 |
| 1QVI | X-ray | 2.54 Å | A=1-840 |
| 3JTD | X-ray | 2.57 Å | A=773-837 |
| 1SR6 | X-ray | 2.75 Å | A=1-840 |
| 1L2O | X-ray | 2.8 Å | A=1-835 |
| 1SCM | X-ray | 2.8 Å | A=777-836 |
| 1KQM | X-ray | 3.0 Å | A=1-835 |
| 1S5G | X-ray | 3.1 Å | A=1-840 |
| 1KK7 | X-ray | 3.2 Å | A=1-837 |
| 1KWO | X-ray | 3.8 Å | A=1-835 |
| 1DFK | X-ray | 4.2 Å | A=6-835 |
| 1DFL | X-ray | 4.2 Å | A/B=5-835 |
| 2W4T | EM | 35.0 Å | C=5-835 |
| 2W4V | EM | 35.0 Å | C=5-835 |
| 2W4W | EM | 35.0 Å | C=5-835 |
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