Exendin-4 is a 87-residue protein from Heloderma suspectum. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26349.
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The mean pLDDT of this model is 72.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 37% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5OTT | X-ray | 1.92 Å | B=48-86 |
| 3C5T | X-ray | 2.1 Å | B=56-86 |
| 3C59 | X-ray | 2.3 Å | B=56-86 |
| 7LLL | EM | 3.7 Å | P=48-86 |
| 1JRJ | NMR | A=48-86 | |
| 2MJ9 | NMR | A=48-86 | |
| 2NAV | NMR | A=48-56 | |
| 2NAW | NMR | A=48-67 | |
| 5NIQ | NMR | A=48-86 | |
| 6GDZ | NMR | A=48-86 | |
| 6GE2 | NMR | A=48-86 | |
| 7MLL | NMR | A=48-86 | |
| 9G0M | NMR | A=62-86 | |
| 9G0N | NMR | A=62-86 | |
| 9G20 | NMR | A=62-86 | |
| 9G21 | NMR | A=62-86 | |
| 9G22 | NMR | A=62-86 | |
| 9G2N | NMR | A=62-86 | |
| 9G2O | NMR | A=62-86 | |
| 9G31 | NMR | A=62-86 |
Showing 20 of 22 experimental structures (best resolution first).
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