9G31: Exendin-4

Trp-cage fortified Tc5b-Exenatide chimera (Ex-4-Tc5bDR) at 310K. Determined by solution NMR. Released 25 Sept 2024.

Method

Solution NMR

Organism

Heloderma suspectum

Chains

1

Atoms

196

Mol. weight

2.77 kDa

Released

25 Sept 2024

Explore 9G31 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9G31 contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Molecules and chains

>9G31_1 Exendin-4 (chains A)
EEEAVRLYIQWLKDGGPSSGRPPPS

Primary citation

Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives. Horvath, D., Straner, P., Taricska, N. et al. J Med Chem (2024) 67:16757-16772. DOI 10.1021/acs.jmedchem.4c01553 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P26349 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 5OTT 1.92 Å, Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs
• 3C5T 2.1 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
• 3C59 2.3 Å, Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular…
• 7LLL 3.7 Å, Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
• 1JRJ Solution structure of exendin-4 in 30-vol% trifluoroethanol
• 2MJ9 Designed Exendin-4 analogues
• 2NAV NMR solution structure of Ex-4[1-16]/pl14a
• 2NAW NMR solution structure of Exendin-4/conotoxin chimera (Ex-4[1-27]/pl14a)
• 5NIQ exendin-4 variant with dual GLP-1 / glucagon receptor activity
• 6GDZ exendin-4 based dual GLP-1/glucagon receptor agonist
• 6GE2 exendin-4 based dual GLP-1/glucagon receptor agonist
• 7MLL Solution structure of Exenatide (exendin-4) in 30-vol% trifluoroethanol using CS-Rosetta

Browse structure collections

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