Vasopressin V2 receptor (AVPR2) is a 371-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30518.
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The mean pLDDT of this model is 76.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption (PubMed:1534149, PubMed:19440390, PubMed:33664408, PubMed:33742150). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:33664408, PubMed:33742150). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:33664408, PubMed:33742150)
Interacts with ARRDC4 (PubMed:23236378). Identified in a complex containing at least ARRDC4, V2R and HGS (PubMed:23236378). Interacts with TMEM147 (PubMed:21056967). Interacts (when phosphorylated) with ARRB2; the interaction is associated with internalization of the receptor and short-term desensitization to the ligand (PubMed:37209686)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7DFC | X-ray | 2.49 Å | V=346-367 |
| 9HAP | EM | 2.5 Å | R=4-371 |
| 9HB3 | EM | 2.5 Å | R=4-371 |
| 7DFA | X-ray | 2.54 Å | V=346-368 |
| 4JQI | X-ray | 2.6 Å | V=343-371 |
| 7DW9 | EM | 2.6 Å | R=1-371 |
| 7KH0 | EM | 2.8 Å | R=1-371 |
| 9WSV | EM | 2.8 Å | R=342-371 |
| 9WSW | EM | 2.8 Å | R=342-371 |
| 9WSX | EM | 2.8 Å | R=342-371 |
| 9UVW | EM | 2.89 Å | A=1-236, A=265-371 |
| 9UYN | EM | 2.9 Å | R=343-371 |
| 9U80 | EM | 2.94 Å | R=35-234, R=264-371 |
| 9UVY | EM | 2.98 Å | A=1-236, A=239-247, A=251-256, A=260-371 |
| 9LZ2 | EM | 3.0 Å | R=343-368 |
| 9UVV | EM | 3.02 Å | A=1-236, A=265-371 |
| 9U81 | EM | 3.08 Å | R=33-234, R=264-371 |
| 9LY2 | EM | 3.1 Å | R=343-371 |
| 7DF9 | X-ray | 3.17 Å | V=346-368 |
| 8WU1 | EM | 3.2 Å | R=342-371 |
Showing 20 of 42 experimental structures (best resolution first).
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