Somatostatin receptor type 2 (SSTR2) is a 369-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30874.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 81.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate…
Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this…
Cell membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7T10 | EM | 2.5 Å | R=1-237, R=253-369 |
| 7XN9 | X-ray | 2.6 Å | A=2-239, A=243-359 |
| 7XNA | X-ray | 2.65 Å | A=2-237, A=244-359 |
| 7T11 | EM | 2.7 Å | R=1-237, R=253-369 |
| 7WIG | EM | 2.7 Å | R=1-369 |
| 7WIC | EM | 2.8 Å | R=1-369 |
| 7XAT | EM | 2.85 Å | A=1-361 |
| 7XAV | EM | 2.87 Å | A=1-361 |
| 7XAU | EM | 2.97 Å | A=1-361 |
| 7UL5 | EM | 3.1 Å | A=1-237, A=254-369 |
| 7XMR | EM | 3.1 Å | R=2-359 |
| 7YAC | EM | 3.24 Å | E=31-338 |
| 7Y24 | EM | 3.25 Å | E=1-327 |
| 7Y26 | EM | 3.3 Å | E=1-337 |
| 7YAE | EM | 3.37 Å | E=1-369 |
| 7Y27 | EM | 3.48 Å | E=1-337 |
| 7WJ5 | EM | 3.72 Å | R=1-369 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.