Calcitonin receptor (CALCR) is a 474-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30988.
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The mean pLDDT of this model is 78.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed:35324283, PubMed:38603770). IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed:35324283, PubMed:38603770). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates…
Heterodimer of CALCR and RAMP1, RAMP2 or RAMP3; the receptor complexes function as AMYR1, AMYR2 and AMYR3 receptors, respectively, and respond to amylin/IAPP, calcitonin/CT and CGRP1 ligands (PubMed:35324283, PubMed:38603770). Interacts with GPRASP2 (PubMed:15086532)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6PFO | X-ray | 1.78 Å | A/B=38-141 |
| 8F0K | EM | 1.9 Å | R=25-474 |
| 8F0J | EM | 2.0 Å | R=25-474 |
| 8F2B | EM | 2.0 Å | R=25-474 |
| 5II0 | X-ray | 2.1 Å | A/B/C=25-144 |
| 7TYF | EM | 2.2 Å | R=25-474 |
| 8F2A | EM | 2.2 Å | R=25-474 |
| 9BP3 | EM | 2.2 Å | R=25-474 |
| 9BUB | EM | 2.3 Å | R=25-474 |
| 7TZF | EM | 2.4 Å | R=25-474 |
| 9AUC | EM | 2.4 Å | R=25-474 |
| 9BUD | EM | 2.5 Å | R=25-474 |
| 7TYX | EM | 2.55 Å | R=25-474 |
| 7TYN | EM | 2.6 Å | R=25-474 |
| 7TYO | EM | 2.7 Å | R=25-474 |
| 9BQ3 | EM | 2.8 Å | R=25-474 |
| 6PGQ | X-ray | 2.85 Å | A=39-141 |
| 7TYW | EM | 3.0 Å | R=25-474 |
| 7TYY | EM | 3.0 Å | R=25-474 |
| 9BTW | EM | 3.0 Å | R=25-474 |
Showing 20 of 30 experimental structures (best resolution first).
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