5N5Y: RNA polymerase I

Name: PDB 5N5Y: Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III)
Published: 2017-04-05
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III). Determined by electron microscopy at 7.7 Å resolution. Released 5 Apr 2017.

Method: Electron microscopy
Resolution: 7.7 Å
Organism: Saccharomyces cerevisiae
Chains: 18
Atoms: 48,030
Mol. weight: 885.7 kDa
Ligands: ZN, MG
Released: 5 Apr 2017

Explore 5N5Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5N5Y contains 308 α-helices and 287 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 93 helices, 67 β-strands

Element	Residues	Length	Sheet
β-strand	10-18	9	1
α-helix	21-27	7
β-strand	31	1	2
β-strand	34	1	3
β-strand	38	1	4
α-helix	43	1
β-strand	44	1	4
α-helix	45	1
β-strand	48	1	3
α-helix	52-54	3
α-helix	61-62	2
β-strand	77-86	10	2
α-helix	88-90	3
α-helix	91-100	10
β-strand	101	1	5
β-strand	108	1	5
α-helix	112-126	15
α-helix	130-135	6
α-helix	136-138	3
α-helix	175-198	24
β-strand	203	1	6
β-strand	206	1	6
α-helix	210-228	19
α-helix	240-241	2
β-strand	242-245	4	7
β-strand	251-254	4	7
α-helix	255-257	3
α-helix	258-266	9
β-strand	314	1	7
α-helix	317-330	14
α-helix	332-338	7
α-helix	352-355	4
β-strand	356-362	7	2
α-helix	363-364	2
α-helix	365-367	3
β-strand	371-373	3	8
β-strand	376-378	3	8
α-helix	381-404	24
α-helix	415-435	21
α-helix	440-442	3
α-helix	444-446	3
α-helix	452-454	3
α-helix	456-461	6
α-helix	466-470	5
β-strand	479-486	8	9
β-strand	494-497	4	9
α-helix	499-502	4
β-strand	508-510	3	10
α-helix	511	1
α-helix	516-525	10
β-strand	533-537	5	10
β-strand	543-545	3	10
α-helix	551-558	8
α-helix	568-570	3
β-strand	576-579	4	10
α-helix	580-581	2
β-strand	586-590	5	9
α-helix	597-599	3
β-strand	600-607	8	9
β-strand	614-616	3	9
α-helix	618-620	3
α-helix	621-624	4
β-strand	632-636	5	9
α-helix	641-649	9
β-strand	652	1	9
β-strand	658	1	11
β-strand	665	1	11
α-helix	672-680	9
β-strand	686-688	3	12
α-helix	689-700	12
α-helix	715-717	3
β-strand	719-721	3	12
β-strand	725-727	3	12
α-helix	728-739	12
α-helix	745-747	3
β-strand	749-752	4	13
α-helix	757-759	3
β-strand	768-772	5	13
β-strand	775-778	4	13
α-helix	783-786	4
α-helix	793-824	32
α-helix	830-833	4
α-helix	834	1
β-strand	835	1	14
α-helix	836	1
α-helix	837-847	11
α-helix	848-850	3
α-helix	853-861	9
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	14
α-helix	924-931	8
α-helix	937-944	8
β-strand	948-949	2	15
β-strand	952	1	16
β-strand	955	1	16
α-helix	970	1
α-helix	976-979	4
β-strand	981-982	2	15
β-strand	985	1	17
β-strand	989	1	17
α-helix	993-1005	13
α-helix	1017-1027	11
β-strand	1031-1032	2	18
β-strand	1038-1039	2	18
β-strand	1045-1047	3	18
β-strand	1055	1	19
α-helix	1066-1070	5
α-helix	1073-1080	8
α-helix	1082-1088	7
β-strand	1090	1	20
α-helix	1093-1107	15
α-helix	1113-1115	3
α-helix	1123-1126	4
β-strand	1132	1	20
α-helix	1138-1150	13
α-helix	1152-1155	4
α-helix	1163-1175	13
β-strand	1178	1	19
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1196-1200	5
α-helix	1218-1226	9
β-strand	1237-1241	5	21
β-strand	1242	1	22
α-helix	1248-1258	11
β-strand	1261-1262	2	23
α-helix	1263-1266	4
β-strand	1267-1275	9	24
β-strand	1288-1296	9	24
α-helix	1299-1306	8
α-helix	1311-1316	6
α-helix	1317-1321	5
α-helix	1322-1335	14
α-helix	1442-1452	11
β-strand	1457-1462	6	24
β-strand	1469-1476	8	24
α-helix	1480-1482	3
α-helix	1485-1493	9
β-strand	1497-1499	3	23
β-strand	1507-1508	2	21
β-strand	1513	1	25
β-strand	1516	1	25
β-strand	1518-1522	5	21
α-helix	1526-1529	4
α-helix	1530-1532	3
β-strand	1536	1	22
α-helix	1538-1540	3
β-strand	1542-1543	2	21
α-helix	1546-1553	8
α-helix	1555-1572	18
α-helix	1579-1589	11
α-helix	1600-1603	4
α-helix	1609-1613	5
α-helix	1618-1627	10
β-strand	1631-1632	2	1
α-helix	1637-1643	7
α-helix	1645-1647	3
α-helix	1650-1652	3
β-strand	1654-1658	5	26

Chain B: 54 helices, 73 β-strands

Element	Residues	Length	Sheet
α-helix	18-26	9
α-helix	36-41	6
α-helix	43-50	8
α-helix	60-68	9
β-strand	71-74	4	27
β-strand	94-104	11	27
β-strand	108-109	2	28
β-strand	119-120	2	28
α-helix	123-129	7
β-strand	134-145	12	27
β-strand	150-162	13	27
α-helix	177-182	6
β-strand	194-196	3	29
β-strand	199-203	5	29
β-strand	206	1	30
β-strand	211	1	31
β-strand	214-218	5	31
α-helix	220-225	6
β-strand	229-239	11	31
β-strand	245-253	9	31
β-strand	258-264	7	31
β-strand	267-272	6	31
α-helix	273-280	8
α-helix	285-293	9
α-helix	300-313	14
α-helix	323-334	12
α-helix	346-357	12
α-helix	360-362	3
α-helix	367-385	19
α-helix	390-392	3
α-helix	397-399	3
β-strand	403	1	30
α-helix	405-434	30
α-helix	443-451	9
α-helix	457-467	11
β-strand	469	1	32
β-strand	482	1	32
β-strand	485-487	3	29
α-helix	493-499	7
β-strand	502-503	2	33
β-strand	504	1	30
α-helix	507-510	4
α-helix	522-524	3
β-strand	528	1	34
β-strand	543-544	2	33
β-strand	545	1	34
β-strand	550	1	35
α-helix	561-567	7
α-helix	570	1
β-strand	571-572	2	36
α-helix	573-575	3
β-strand	584-588	5	36
β-strand	591-596	6	36
α-helix	598-614	17
β-strand	625-629	5	36
α-helix	637-638	2
β-strand	639-643	5	36
β-strand	650	1	35
β-strand	651-655	5	37
β-strand	660-664	5	37
α-helix	666-669	4
β-strand	674-675	2	37
α-helix	678-680	3
β-strand	688-689	2	37
α-helix	693-696	4
α-helix	707-709	3
β-strand	710	1	38
α-helix	712-722	11
β-strand	725	1	39
α-helix	733-735	3
β-strand	740-744	5	40
β-strand	752-753	2	41
α-helix	755-759	5
α-helix	762-764	3
β-strand	769-775	7	39
β-strand	786-790	5	39
α-helix	791-795	5
β-strand	801-810	10	40
α-helix	819-821	3
β-strand	823-825	3	42
α-helix	835-838	4
β-strand	840	1	43
β-strand	846	1	43
α-helix	847	1
β-strand	851-852	2	40
β-strand	857-863	7	42
β-strand	868-873	6	42
β-strand	880-888	9	40
α-helix	896-898	3
β-strand	900-909	10	40
β-strand	916-919	4	39
β-strand	924-931	8	39
β-strand	938-939	2	44
α-helix	943-945	3
β-strand	947-949	3	39
α-helix	951-953	3
β-strand	959	1	38
α-helix	960-975	16
β-strand	979-980	2	41
β-strand	987	1	45
β-strand	990	1	45
α-helix	992-1003	12
β-strand	1010-1011	2	39
β-strand	1013-1014	2	44
β-strand	1021	1	44
α-helix	1022	1
β-strand	1026-1036	11	39
α-helix	1037	1
β-strand	1045-1047	3	9
β-strand	1052	1	47
β-strand	1059	1	47
α-helix	1060	1
α-helix	1073-1082	10
α-helix	1085-1090	6
α-helix	1091-1095	5
β-strand	1098-1104	7	48
β-strand	1113-1115	3	49
α-helix	1118-1119	2
β-strand	1126-1128	3	49
β-strand	1133-1134	2	50
α-helix	1135-1139	5
α-helix	1155-1157	3
β-strand	1158-1160	3	50
β-strand	1166-1168	3	50
β-strand	1173-1179	7	48
α-helix	1180-1191	12
β-strand	1194-1201	8	1

Chain C: 16 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-46	6	51
β-strand	51-57	7	51
α-helix	61-73	13
β-strand	77-88	12	52
α-helix	94-103	10
α-helix	105	1
β-strand	106-107	2	53
α-helix	110-112	3
α-helix	114-117	4
α-helix	122-125	4
β-strand	132-139	8	52
β-strand	141-142	2	54
α-helix	153-156	4
β-strand	157-158	2	54
β-strand	161-163	3	55
α-helix	164-166	3
β-strand	168-170	3	52
α-helix	175-178	4
β-strand	185-186	2	53
β-strand	192-195	4	55
β-strand	201-211	11	52
α-helix	217-219	3
β-strand	222-235	14	51
β-strand	240	1	56
α-helix	242-248	7
β-strand	256-258	3	57
β-strand	264	1	56
β-strand	265-267	3	57
α-helix	270-272	3
α-helix	278-281	4
α-helix	283-286	4
β-strand	289-304	16	51
α-helix	310-329	20
β-strand	334	1	58

Chain D: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	59
β-strand	29-30	2	59
α-helix	33-46	14
α-helix	81-95	15

Chain E: 17 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	6-25	20
β-strand	28	1	60
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	61
β-strand	53	1	61
α-helix	55-58	4
β-strand	60-62	3	62
β-strand	64	1	60
α-helix	66-71	6
β-strand	78-82	5	62
β-strand	87-88	2	63
α-helix	90-102	13
β-strand	107-112	6	62
β-strand	115-116	2	63
α-helix	118-121	4
β-strand	131-136	6	62
α-helix	137-139	3
α-helix	144-146	3
α-helix	151	1
β-strand	152-155	4	64
α-helix	156-157	2
α-helix	158-167	10
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	64
α-helix	183-188	6
α-helix	190-191	2
β-strand	195-201	7	64
α-helix	202	1
β-strand	207-214	8	64

Chain F: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	56-73	18
α-helix	76-78	3
β-strand	84	1	65
α-helix	85-86	2
α-helix	87-102	16
α-helix	117-126	10
β-strand	132-137	6	26
α-helix	138	1
β-strand	143-147	5	26
β-strand	152	1	65
α-helix	153	1

Chain G: 9 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	26-27	2
β-strand	28	1	66
α-helix	29	1
β-strand	35	1	66
β-strand	38-49	12	59
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
α-helix	67-69	3
β-strand	73-74	2	59
β-strand	79-89	11	59
β-strand	106	1	26
β-strand	107	1	59
α-helix	108	1
β-strand	114-125	12	59
β-strand	132-140	9	67
β-strand	144-149	6	67
β-strand	153-158	6	67
β-strand	167-169	3	68
β-strand	216-218	3	68
α-helix	223	1
β-strand	224	1	68
α-helix	225	1
β-strand	228-237	10	67
β-strand	244-248	5	67

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	12
β-strand	23-30	8	12
β-strand	37-43	7	12
β-strand	54-60	7	12
α-helix	89-92	4
β-strand	95-106	12	12
β-strand	111-118	8	12
β-strand	121-128	8	12
β-strand	139-145	7	12

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae	P40422

6 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>5N5Y_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>5N5Y_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>5N5Y_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>5N5Y_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>5N5Y_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>5N5Y_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>5N5Y_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>5N5Y_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>5N5Y_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>5N5Y_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>5N5Y_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>5N5Y_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	8
MG	Magnesium ion	Mg	1

Water and common crystallization additives (SO4) are not listed.

Primary citation

Structural Basis of RNA Polymerase I Transcription Initiation. Engel, C., Gubbey, T., Neyer, S. et al. Cell (2017) 169:120-131.e22. DOI 10.1016/j.cell.2017.03.003 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

Browse structure collections

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