RNA polymerase I-specific transcription initiation factor RRN7 (RRN7) is a 514-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P40992.
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The mean pLDDT of this model is 71.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 6% |
| 70 to 90 | Confident: backbone generally right | 55% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a pre-initiation complex
Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN7 interacts with RRN6, RRN11, SPT15 and RRN9
Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6RUI | EM | 2.7 Å | Q=1-514 |
| 6RQL | EM | 2.9 Å | Q=1-514 |
| 6RWE | EM | 3.0 Å | Q=1-514 |
| 6RRD | EM | 3.1 Å | Q=1-514 |
| 5O7X | X-ray | 3.2 Å | B/E/H/K/N/Q=1-514 |
| 5N61 | EM | 3.4 Å | Q=1-514 |
| 6RUO | EM | 3.5 Å | Q=1-514 |
| 6TPS | EM | 3.54 Å | Q=1-514 |
| 6RQH | EM | 3.7 Å | Q=1-514 |
| 5W5Y | EM | 3.8 Å | P=1-514 |
| 5W66 | EM | 3.9 Å | P=1-514 |
| 5W64 | EM | 4.2 Å | P=1-514 |
| 5W65 | EM | 4.3 Å | P=1-514 |
| 5OA1 | EM | 4.4 Å | U=1-514 |
| 5N5Y | EM | 7.7 Å | Q=1-514 |
| 5N5Z | EM | 7.7 Å | Q=1-514 |
| 5N60 | EM | 7.7 Å | Q=1-514 |
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