Epithelial sodium channel subunit beta (SCNN1B) is a 640-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51168.
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The mean pLDDT of this model is 82.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7762608, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24124190). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:24124190)
Component of the heterotrimeric epithelial sodium channel (ENaC) composed of an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit (PubMed:16423824, PubMed:30251954, PubMed:32729833). An additional delta/SCNN1D subunit can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (PubMed:7499195, PubMed:16423824). Interacts with WWP1 (via WW domains)…
Apical cell membrane, Cytoplasmic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6WTH | EM | 3.06 Å | B=1-640 |
| 9BTG | EM | 3.12 Å | A/B=1-640 |
| 9BLR | EM | 3.38 Å | B=1-640 |
| 9BTU | EM | 3.68 Å | B=1-640 |
| 6BQN | EM | 3.9 Å | B=73-515 |
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