Alpha-bungarotoxin is a 95-residue protein from Bungarus multicinctus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60615.
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The mean pLDDT of this model is 89.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Binds with high affinity to muscular (tested on Torpedo marmorata, Kd=0.4 nM) and neuronal (tested on chimeric alpha-7/CHRNA7, Kd=0.95 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:9305882). It also shows an activity on GABA(A) receptors (PubMed:16549768, PubMed:25634239). It antagonises GABA-activated currents with high potency when tested on primary hippocampal neurons (PubMed:25634239). It inhibits recombinantly expressed GABA(A) receptors composed of alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits with high potency (62.3% inhibition at 20 uM of toxin)…
Monomer in solution, homodimer in crystal state
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9FYS | X-ray | 1.32 Å | X/Z=1-95 |
| 9HUB | X-ray | 1.33 Å | X/Z=1-95 |
| 1HC9 | X-ray | 1.8 Å | B=22-95 |
| 9GU1 | EM | 2.48 Å | I/J=22-95 |
| 2ABX | X-ray | 2.5 Å | A/B=22-95 |
| 8DA1 | X-ray | 2.67 Å | I=22-95 |
| 6UWZ | EM | 2.69 Å | F/G=22-95 |
| 9GU0 | EM | 2.96 Å | I/J=22-95 |
| 1ABT | NMR | A=22-95 | |
| 1BXP | NMR | A=22-95 | |
| 1HAA | NMR | A=22-95 | |
| 1HAJ | NMR | A=22-95 | |
| 1HOY | NMR | A=22-95 | |
| 1IDG | NMR | A=22-95 | |
| 1IDH | NMR | A=22-95 | |
| 1IDI | NMR | A=22-95 | |
| 1IDL | NMR | A=22-95 | |
| 1IK8 | NMR | A=22-95 | |
| 1IKC | NMR | A=22-95 | |
| 1JBD | NMR | A=22-95 |
Showing 20 of 27 experimental structures (best resolution first).
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