Heterogeneous nuclear ribonucleoprotein K (HNRNPK) is a 463-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61978.
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The mean pLDDT of this model is 64.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 40% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the…
Identified in the spliceosome C complex (PubMed:11991638). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPL (PubMed:33174841). Interacts with RBM42 and ZIK1 (By similarity). Interacts with BRDT (By similarity). Interacts with ANKRD28 (PubMed:16564677). Interacts with ASFV p30 protein (PubMed:18775702). Interacts with…
Cytoplasm, Nucleus, nucleoplasm, Cell projection, podosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1ZZK | X-ray | 0.95 Å | A=385-463 |
| 7RJO | X-ray | 1.38 Å | B=57-66 |
| 1ZZI | X-ray | 1.8 Å | A/B=385-463 |
| 7RJK | X-ray | 1.85 Å | C/D=57-66 |
| 1ZZJ | X-ray | 2.3 Å | A/B/C=385-463 |
| 7CRU | X-ray | 2.8 Å | B/D=18-38 |
| 7CRE | X-ray | 3.0 Å | A=382-457 |
| 1J5K | NMR | A=379-463 | |
| 1KHM | NMR | A=375-463 |
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