Gamma-aminobutyric acid receptor subunit alpha-1 (Gabra1) is a 455-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62812.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:27129275). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-1/GABRA1-containing GABAARs are largely synaptic (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening…
Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) subunits, each subunit exhibiting distinct physiological and pharmacological properties (PubMed:25422464). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (PubMed:16380713). Interacts with KIF21B (By similarity).…
Postsynaptic cell membrane, Cell membrane, Cytoplasmic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8FOI | EM | 2.5 Å | A/C=1-455 |
| 8G4X | EM | 2.56 Å | A=1-455 |
| 8G5F | EM | 2.64 Å | C=1-455 |
| 8G4N | EM | 2.67 Å | A/C=1-455 |
| 5OSA | X-ray | 2.75 Å | A/B/C/D/E=250-338, A/B/C/D/E=417-455 |
| 8G5H | EM | 2.89 Å | C=1-455 |
| 8G5G | EM | 2.94 Å | A=1-455 |
| 8G4O | EM | 3.06 Å | A/C=1-455 |
| 5OSC | X-ray | 3.1 Å | A/B/C/D/E=421-455 |
| 5OSB | X-ray | 3.8 Å | A/B/C/D/E=250-338, A/B/C/D/E=417-455 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.