Troponin C, slow skeletal and cardiac muscles (TNNC1) is a 161-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P63316.
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The mean pLDDT of this model is 79.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 86% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3SD6 | X-ray | 1.37 Å | A=1-89 |
| 4GJE | X-ray | 1.6 Å | A=1-89 |
| 3SWB | X-ray | 1.67 Å | A=1-89 |
| 7SC2 | X-ray | 1.81 Å | A=1-92 |
| 4GJF | X-ray | 1.9 Å | A=1-89 |
| 4GJG | X-ray | 2.0 Å | A=1-89 |
| 4Y99 | X-ray | 2.0 Å | A=1-161 |
| 1WRK | X-ray | 2.15 Å | A/B=1-88 |
| 3RV5 | X-ray | 2.2 Å | A/B/C/D=1-89 |
| 7SC3 | X-ray | 2.23 Å | A=1-92 |
| 1WRL | X-ray | 2.6 Å | A/B/C/D/E/F=1-88 |
| 1J1D | X-ray | 2.61 Å | A/D=1-161 |
| 8FMO | X-ray | 2.61 Å | A/D=1-161 |
| 8FMT | X-ray | 2.8 Å | A/D=1-161 |
| 8FMN | X-ray | 3.1 Å | A/D=1-161 |
| 8FMM | X-ray | 3.11 Å | A/D=1-161 |
| 8FMP | X-ray | 3.24 Å | A/D=1-161 |
| 8FMR | X-ray | 3.24 Å | A/D=1-161 |
| 8FMQ | X-ray | 3.25 Å | A/D=1-161 |
| 1J1E | X-ray | 3.3 Å | A/D=1-161 |
Showing 20 of 61 experimental structures (best resolution first).
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