Ankyrin-2 (ANK2) is a 555-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q01484.
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The mean pLDDT of this model is 61.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the…
Interacts with RHBG and SPTBN1 (PubMed:15262991, PubMed:15611082). Colocalizes with Na/K ATPase, Na/Ca exchanger and SPTBN1 (PubMed:19007774). Directly interacts with DMD; this interaction is necessary for DMD localization at the sarcolemma. Interacts with DCTN4; this interaction is required for DCTN4 retention at costameres. Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2,…
Cytoplasm, cytoskeleton, Membrane, Cytoplasm, myofibril, sarcomere, M line, Apical cell membrane, Cell membrane, Postsynaptic cell membrane, Early endosome, Recycling endosome, Lysosome, Mitochondrion, Cytoplasm, myofibril, sarcomere, Z line, Cell membrane, sarcolemma, T-tubule, Photoreceptor…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6KZJ | X-ray | 1.5 Å | A=1499-1570 |
| 5Y4F | X-ray | 1.95 Å | A/B=430-873 |
| 8ZE8 | X-ray | 2.07 Å | C/E/F/H=1699-1710 |
| 4D8O | X-ray | 2.2 Å | A=966-3653 |
| 5YIS | X-ray | 2.2 Å | C/D=1588-1614 |
| 5Y4E | X-ray | 2.34 Å | A/B=264-483 |
| 4RLY | X-ray | 2.5 Å | A=28-318 |
| 5YIR | X-ray | 2.75 Å | C/G/H=1588-1614 |
| 5Y4D | X-ray | 3.3 Å | A=28-693 |
| 6M3Q | X-ray | 3.44 Å | E=951-1458 |
| 4RLV | X-ray | 3.49 Å | A=29-873 |
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