Focal adhesion kinase 1 (PTK2) is a 1052-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q05397.
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The mean pLDDT of this model is 74.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin…
Interacts (via first Pro-rich region) with CAS family members (via SH3 domain), including BCAR1, BCAR3, and CASS4. Interacts with NEDD9 (via SH3 domain) (PubMed:9360983). Interacts with GIT1. Interacts with SORBS1. Interacts with ARHGEF28. Interacts with SHB. Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (PubMed:29069646). Interacts with PXN and TLN1. Interacts with STAT1.…
Cell junction, focal adhesion, Cell membrane, Cytoplasm, perinuclear region, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6YOJ | X-ray | 1.36 Å | A=411-689 |
| 6YT6 | X-ray | 1.54 Å | A/B=411-689 |
| 4I4E | X-ray | 1.55 Å | A=411-686 |
| 1MP8 | X-ray | 1.6 Å | A=411-686 |
| 4EBV | X-ray | 1.67 Å | A=411-686 |
| 4I4F | X-ray | 1.75 Å | A=411-686 |
| 6YQ1 | X-ray | 1.78 Å | A/B/C/D=411-689 |
| 3PXK | X-ray | 1.79 Å | A/B=410-689 |
| 6YVS | X-ray | 1.81 Å | A/B/C/D=411-689 |
| 6YVY | X-ray | 1.92 Å | A/B/C/D=411-689 |
| 6YR9 | X-ray | 1.93 Å | A/B/C/D=411-689 |
| 7W8I | X-ray | 1.94 Å | A=892-1052 |
| 1K04 | X-ray | 1.95 Å | A=891-1052 |
| 4GU6 | X-ray | 1.95 Å | A/B=411-689 |
| 6PW8 | X-ray | 1.95 Å | A=922-1047 |
| 6I8Z | X-ray | 1.99 Å | A=411-689 |
| 4K9Y | X-ray | 2.0 Å | A=410-686 |
| 6LES | X-ray | 2.0 Å | A/B/X/Y=805-832 |
| 4Q9S | X-ray | 2.07 Å | A=411-686 |
| 7W8B | X-ray | 2.09 Å | A=892-1052 |
Showing 20 of 40 experimental structures (best resolution first).
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