Mitotic-spindle organizing protein 1 (MZT1) is a 82-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q08AG7.
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The mean pLDDT of this model is 92.2 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 82% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809)
Associates with the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2; within the complex, interacts with TUBGCP3 and TUBGCP6 to form a luminal bridge with actin that stabilizes the initial structure during complex assembly (PubMed:38609661, PubMed:39321809). Interacts with TUBG1 (PubMed:20360068)
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6L81 | X-ray | 2.2 Å | B/D=1-82 |
| 6M33 | X-ray | 3.29 Å | B=1-82 |
| 8RX1 | EM | 3.57 Å | a/c=1-82 |
| 6X0U | EM | 3.6 Å | A/C=1-82 |
| 7AS4 | EM | 4.13 Å | 5/6=1-82 |
| 9QVN | EM | 4.7 Å | O/P/Q/R/S/T/U=1-82 |
| 7QJ0 | EM | 5.32 Å | b/m=1-82 |
| 9QVM | EM | 6.8 Å | O/P/Q/R/S/T/U=1-82 |
| 7QJ1 | EM | 7.0 Å | b/m=1-82 |
| 8VRD | EM | 7.0 Å | Q/R=1-82 |
| 7QJD | EM | 7.1 Å | b/d/g/i/k/m/o=1-82 |
| 7QJ3 | EM | 7.6 Å | b/m/o=1-82 |
| 8VRJ | EM | 7.7 Å | 7/8=1-82 |
| 7QJ6 | EM | 7.8 Å | b/d/i/k/m=1-82 |
| 7QJ9 | EM | 8.1 Å | b/d/i/k/m=1-82 |
| 8VRK | EM | 8.5 Å | 7/8=1-82 |
| 7QJ2 | EM | 8.6 Å | b/k/m=1-82 |
| 7QJ5 | EM | 8.7 Å | b/d/g/i/k/m=1-82 |
| 7QJ7 | EM | 8.7 Å | b/d/g/i/k/m=1-82 |
| 7QJ8 | EM | 8.7 Å | b/d/i/k/m=1-82 |
Showing 20 of 26 experimental structures (best resolution first).
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