Rho guanine nucleotide exchange factor TIAM1 (TIAM1) is a 1591-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13009.
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The mean pLDDT of this model is 58.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration
Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus)
Cell junction, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3KZD | X-ray | 1.3 Å | A=841-930 |
| 4GVC | X-ray | 1.54 Å | A=841-930 |
| 3KZE | X-ray | 1.8 Å | A/B/C=841-930 |
| 4GVD | X-ray | 1.85 Å | A/B=841-930 |
| 4NXR | X-ray | 1.9 Å | A=841-930 |
| 4K2P | X-ray | 1.98 Å | A/B/C/D=429-702 |
| 4NXQ | X-ray | 2.1 Å | A/B/C=841-930 |
| 4K2O | X-ray | 2.15 Å | A=429-702 |
| 4NXP | X-ray | 2.3 Å | A=841-930 |
| 2D8I | NMR | A=835-935 |
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