Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) is a 524-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13362.
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The mean pLDDT of this model is 84.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families),…
Nucleus, Chromosome, centromere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5JJA | X-ray | 2.35 Å | A/B=30-380 |
| 6VRO | X-ray | 2.45 Å | A=31-380 |
| 2JAK | X-ray | 2.6 Å | A=11-380 |
| 3FGA | X-ray | 2.7 Å | B=34-436 |
| 5K6S | X-ray | 2.79 Å | A=31-380 |
| 5SWF | X-ray | 2.82 Å | A=31-380 |
| 5SW9 | X-ray | 2.85 Å | A=31-380 |
| 9GNJ | X-ray | 2.85 Å | A=30-380 |
| 7OUF | EM | 3.0 Å | C/F=11-380 |
| 7OUG | EM | 3.1 Å | C/F=11-380 |
| 6OYL | X-ray | 3.15 Å | A=31-380 |
| 6TOQ | X-ray | 3.16 Å | AAA=11-380 |
| 9MF5 | EM | 3.2 Å | B=1-524 |
| 2NPP | X-ray | 3.3 Å | B/E=1-442 |
| 7PEL | EM | 3.34 Å | C/F=11-380 |
| 7SOY | EM | 3.4 Å | B=1-442 |
| 9MIP | EM | 3.4 Å | B=1-524 |
| 2IAE | X-ray | 3.5 Å | B/E=30-436 |
| 7OUH | EM | 3.5 Å | C/F=11-380 |
| 2NYM | X-ray | 3.6 Å | B/E=38-425 |
Showing 20 of 22 experimental structures (best resolution first).
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