Acid-sensing ion channel 1 (ASIC1) is a 527-residue protein from Gallus gallus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q1XA76.
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The mean pLDDT of this model is 83.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:16002453, PubMed:17882215, PubMed:19641589, PubMed:24507937). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:22842900, PubMed:24507937). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:24507937). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines.…
Homotrimer (PubMed:17882215, PubMed:19641589, PubMed:22842900). Heterotrimer; with other ASIC proteins producing channel with different properties (By similarity)
Cell membrane, Postsynaptic cell membrane, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2QTS | X-ray | 1.9 Å | A/B/C/D/E/F=26-463 |
| 4NTW | X-ray | 2.07 Å | A=14-463 |
| 4NTX | X-ray | 2.27 Å | A=14-463 |
| 3S3W | X-ray | 2.6 Å | A/B/C=26-463 |
| 4NTY | X-ray | 2.65 Å | A=14-463 |
| 4FZ0 | X-ray | 2.8 Å | A/B/C=14-463 |
| 6VTK | EM | 2.82 Å | A/B/C=1-527 |
| 5WKU | X-ray | 2.95 Å | A/B/C=25-463 |
| 3S3X | X-ray | 2.99 Å | A/B/C=26-463 |
| 3IJ4 | X-ray | 3.0 Å | A=2-466 |
| 4NYK | X-ray | 3.0 Å | A=2-466 |
| 6X9H | X-ray | 3.01 Å | A/B/C=26-463 |
| 5WKV | X-ray | 3.2 Å | A/B/C=25-463 |
| 4FZ1 | X-ray | 3.36 Å | A=14-463 |
| 6VTL | EM | 3.65 Å | A/B/C=1-527 |
| 6CMC | X-ray | 3.67 Å | A=14-463 |
| 6AVE | EM | 3.7 Å | A/B/C=1-527 |
| 5WKY | X-ray | 4.0 Å | A/B/C=25-463 |
| 5WKX | X-ray | 4.03 Å | A/B/C=25-463 |
| 7LIE | NMR | A=291-367 |
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