Myosin-A (MyoA) is a 818-residue protein from Plasmodium falciparum (isolate 3D7). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IDR3.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). In complex with light chains, binds actin and moves actin filaments (PubMed:28893907, PubMed:31337750, PubMed:33046215, PubMed:37308472). Required for parasite invasion into host red blood cells; plays a key role in host erythrocyte deformation and internalization during merozoite invasion (PubMed:31337750, PubMed:33104759)
Component of the glideosome complex composed of GAP50, GAP45, GAP40, MTIP and MyoA; the complex is formed during the late schizont stage and in merozoites (PubMed:16750579, PubMed:25802338, PubMed:28893907). MyoA, MTIP and GAP45 probably form an initial complex in the cytoplasm which is then recruited to the outer face of the inner membrane complex via the interaction with GAP50…
Cell membrane, Inner membrane complex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4MZJ | X-ray | 1.47 Å | T=799-816 |
| 4MZK | X-ray | 1.82 Å | T=799-816 |
| 4AOM | X-ray | 1.94 Å | T=799-816 |
| 4R1E | X-ray | 1.98 Å | B=803-816 |
| 4MZL | X-ray | 2.01 Å | C/D=800-816 |
| 8A12 | X-ray | 2.03 Å | A=1-818 |
| 8CDQ | X-ray | 2.21 Å | A=1-818 |
| 8CDM | X-ray | 2.35 Å | A=1-818 |
| 6ZN3 | X-ray | 2.51 Å | C/F/I/L/O=775-816 |
| 6YCY | X-ray | 2.55 Å | A=1-818 |
| 6I7D | X-ray | 2.82 Å | A/B/C/D=1-768 |
| 6TU7 | EM | 3.1 Å | AP1/GP1=2-818 |
| 6YCZ | X-ray | 3.27 Å | A=1-818 |
| 6I7E | X-ray | 3.49 Å | A=1-768 |
| 7ALN | EM | 3.77 Å | F=1-818 |
| 6YCX | X-ray | 3.99 Å | A/B=1-818 |
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