Regulatory-associated protein of mTOR (RPTOR) is a 1335-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8N122.
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The mean pLDDT of this model is 79.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827,…
Part of the mechanistic target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8 and RPTOR (PubMed:12408816, PubMed:24403073, PubMed:25940091, PubMed:27909983, PubMed:29236692, PubMed:31601708, PubMed:31601764, PubMed:36697823). mTORC1 associates with AKT1S1/PRAS40, which inhibits its activity (PubMed:17386266, PubMed:31601764). mTORC1 associates with DEPTOR, which regulates its…
Lysosome membrane, Cytoplasm, Cytoplasmic granule
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8ERA | EM | 2.86 Å | Y=1-1335 |
| 7UX2 | EM | 2.9 Å | A=1-1335 |
| 6BCX | EM | 3.0 Å | W/Y=2-1335 |
| 8RCN | EM | 3.1 Å | Y=1-1335 |
| 6U62 | EM | 3.18 Å | A=1-1335 |
| 7UXC | EM | 3.2 Å | C=1-1335 |
| 7UXH | EM | 3.2 Å | E/U=1-1335 |
| 9ED4 | EM | 3.23 Å | C/U=1-1335 |
| 9F42 | EM | 3.27 Å | E=1-1335 |
| 8RCK | EM | 3.4 Å | Y=1-1335 |
| 6BCU | EM | 3.43 Å | W/Y=2-1335 |
| 9F43 | EM | 3.49 Å | E=1-1335 |
| 7PEB | EM | 3.67 Å | E=1-1335 |
| 9F44 | EM | 3.68 Å | E/F=1-1335 |
| 9F45 | EM | 3.74 Å | E/F=1-1335 |
| 8RCH | EM | 4.0 Å | W/Y=1-1335 |
| 7PEA | EM | 4.07 Å | E/F=1-1335 |
| 7PEC | EM | 4.24 Å | E=1-1335 |
| 5H64 | EM | 4.4 Å | B/b=1-1335 |
| 7OWG | EM | 4.7 Å | Y=1-1335 |
Showing 20 of 22 experimental structures (best resolution first).
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