Integrator complex subunit 1 (INTS1) is a 2190-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8N201.
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The mean pLDDT of this model is 74.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 59% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound…
Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15 (PubMed:16239144, PubMed:25201415, PubMed:29471365, PubMed:33243860, PubMed:34762484, PubMed:38570683, PubMed:39032490). The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to…
Nucleus, Nucleus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8RC4 | EM | 3.1 Å | a=1-2190 |
| 7CUN | EM | 3.5 Å | A=1-2190 |
| 7PKS | EM | 3.6 Å | a=1-2190 |
| 8RBZ | EM | 3.7 Å | a=1-2190 |
| 8RBX | EM | 4.1 Å | a=1-2190 |
| 8YJB | EM | 4.1 Å | A=1-2190 |
| 7YCX | EM | 4.18 Å | A=1-2190 |
| 9VD9 | EM | 4.6 Å | A=1-2190 |
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