E3 ubiquitin-protein ligase UHRF1 (Uhrf1) is a 782-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8VDF2.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
E3 ubiquitin-protein ligase that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification (PubMed:12058012, PubMed:12084726, PubMed:14993289, PubMed:17673620, PubMed:26065575, PubMed:30392929). Plays a key role in DNA methylation inheritance by promoting recruitment of DNMT1 to hemimethylated DNA and ensure faithful propagation of the DNA methylation patterns through DNA replication (PubMed:17673620, PubMed:21268065, PubMed:26065575). Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 and H3R2me0,…
Interacts with DNMT1; the interaction is direct (PubMed:17994007, PubMed:21268065). Interacts with DNMT3A and DNMT3B (PubMed:19798101). Interacts with HDAC1, but not with HDAC2 (PubMed:15361834). Interacts with BLTP3A. Interacts with EHMT2 (PubMed:19056828). Interacts with PRAMEL7 (PubMed:28604677). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FDE | X-ray | 1.41 Å | A/B=419-628 |
| 2ZKD | X-ray | 1.6 Å | A/B=404-613 |
| 2ZKG | X-ray | 1.77 Å | A/B/C/D=404-613 |
| 2ZO1 | X-ray | 1.96 Å | B=419-628 |
| 3F8J | X-ray | 1.99 Å | B=417-628 |
| 2ZO0 | X-ray | 2.19 Å | B=419-628 |
| 3F8I | X-ray | 2.29 Å | A/B=418-628 |
| 2ZKF | X-ray | 2.55 Å | A=404-613 |
| 2ZKE | X-ray | 2.6 Å | A=404-613 |
| 6M2V | X-ray | 3.0 Å | A/B=417-628 |
| 2ZO2 | X-ray | 3.09 Å | B=419-628 |
| 9XRL | EM | 3.74 Å | AL/AR/x=1-782 |
| 9SFP | EM | 4.2 Å | d=1-782 |
| 9W2M | EM | 4.2 Å | P/Q/p/q=1-782 |
| 6VEE | NMR | A=122-305 | |
| 6VFO | NMR | A=303-380 | |
| 7XGA | NMR | A=304-372 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.