Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a 588-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96RR4.
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The mean pLDDT of this model is 66.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite…
Interacts with calmodulin
Nucleus, Cytoplasm, Cell projection, neuron projection
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y3O | X-ray | 1.5 Å | P=97-104 |
| 6Y8A | X-ray | 1.5 Å | P=508-515 |
| 8TUC | X-ray | 1.5 Å | A=161-449 |
| 5UYJ | X-ray | 1.6 Å | A=161-449 |
| 5UY6 | X-ray | 1.7 Å | A=161-449 |
| 6BQQ | X-ray | 1.8 Å | A=161-449 |
| 5VT1 | X-ray | 1.9 Å | A=161-449 |
| 6BLE | X-ray | 1.9 Å | A=161-449 |
| 5YV8 | X-ray | 1.93 Å | A=158-448 |
| 6BQP | X-ray | 1.95 Å | A=161-449 |
| 6BKU | X-ray | 2.0 Å | A=162-449 |
| 6BQL | X-ray | 2.0 Å | A=161-449 |
| 5YVB | X-ray | 2.02 Å | A=158-448 |
| 5YVC | X-ray | 2.02 Å | A=158-448 |
| 6BRC | X-ray | 2.2 Å | A/B=161-449 |
| 2ZV2 | X-ray | 2.4 Å | A=158-448 |
| 6CMJ | X-ray | 2.4 Å | A/B=149-465 |
| 6EF5 | X-ray | 2.44 Å | Q/S=508-514 |
| 5YV9 | X-ray | 2.53 Å | A=158-448 |
| 5YVA | X-ray | 2.57 Å | A=158-448 |
Showing 20 of 24 experimental structures (best resolution first).
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