Erbin (ERBIN) is a 1412-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96RT1.
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The mean pLDDT of this model is 55.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 60% |
What pLDDT means and how to read it
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes (PubMed:23524970)
Interacts with ERBB2, BPAG1 and ITGB4 (PubMed:10878805, PubMed:11375975, PubMed:12444095). May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin (PubMed:11821434). Interacts (via C-terminus) with DST Isoform 3 (via N-terminus) (PubMed:11375975). Interacts with NOD2 (via CARD domain)…
Cell junction, hemidesmosome, Nucleus membrane, Basolateral cell membrane, Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2H3L | X-ray | 1.0 Å | A/B=1314-1412 |
| 6Q0N | X-ray | 1.18 Å | A/B=1321-1410 |
| 6Q0M | X-ray | 1.2 Å | A/B=1321-1410 |
| 1MFG | X-ray | 1.25 Å | A=1321-1412 |
| 7LUL | X-ray | 1.65 Å | A=1321-1412 |
| 2QBW | X-ray | 1.8 Å | A=1329-1412 |
| 6UBH | X-ray | 1.8 Å | A/B/C/D=1321-1412 |
| 1MFL | X-ray | 1.88 Å | A=1321-1412 |
| 6Q0U | X-ray | 1.89 Å | A/B=1321-1410 |
| 3CH8 | X-ray | 1.9 Å | A=1329-1410 |
| 1N7T | NMR | A=1314-1412 |
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