Solute carrier family 22 member 12 (SLC22A12) is a 553-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96S37.
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The mean pLDDT of this model is 86.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a…
Interacts with PDZK1
Apical cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9RXO | X-ray | 1.2 Å | A/B=549-553 |
| 9RXR | X-ray | 1.69 Å | A=547-553 |
| 9RXS | X-ray | 2.0 Å | A/B=547-553 |
| 9DKC | EM | 2.55 Å | A=1-518 |
| 9DK9 | EM | 2.68 Å | A=1-553 |
| 9B1G | EM | 2.7 Å | A=3-553 |
| 9DKB | EM | 2.74 Å | A=1-518 |
| 9B1F | EM | 2.9 Å | A=3-553 |
| 9B1H | EM | 2.9 Å | A=3-553 |
| 8WJG | EM | 3.0 Å | A=1-538 |
| 9B1J | EM | 3.0 Å | A=3-553 |
| 9B1M | EM | 3.0 Å | A=3-553 |
| 9DKA | EM | 3.0 Å | A=1-518 |
| 9IRX | EM | 3.0 Å | A=1-553 |
| 9B1L | EM | 3.1 Å | A=3-553 |
| 9B1N | EM | 3.1 Å | A=3-553 |
| 9B1O | EM | 3.1 Å | A=3-553 |
| 9IRY | EM | 3.2 Å | A=1-553 |
| 9JDY | EM | 3.23 Å | A=1-553 |
| 9JE0 | EM | 3.23 Å | A=1-553 |
Showing 20 of 28 experimental structures (best resolution first).
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