Protein PAXX (PAXX) is a 204-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BUH6.
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The mean pLDDT of this model is 82.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:25574025, PubMed:25670504, PubMed:25941166, PubMed:27705800). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:25574025, PubMed:25670504, PubMed:25941166). Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (PubMed:27703001). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends…
Homodimer (PubMed:25574025). Interacts with the DNA-bound XRCC5/Ku80 and XRCC6/Ku70 heterodimer (Ku complex); the interaction is direct (PubMed:25574025, PubMed:27601299, PubMed:27705800). Associated component of the non-homologous end joining (NHEJ) complex, composed of the core proteins PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (PubMed:25670504, PubMed:25941166). Interacts with…
Nucleus, Chromosome, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3WTD | X-ray | 2.35 Å | A/B=1-166 |
| 4WJA | X-ray | 2.6 Å | A/B=1-145 |
| 7ZYG | EM | 2.68 Å | C=1-204 |
| 7ZWA | EM | 2.8 Å | C=1-204 |
| 9CQ3 | EM | 2.8 Å | G/H=1-204 |
| 9GYF | EM | 2.8 Å | C=180-202 |
| 9N81 | EM | 2.8 Å | G/H=1-204 |
| 8ASC | X-ray | 2.95 Å | J/T=177-204 |
| 9CQ6 | EM | 3.1 Å | G/H=1-204 |
| 9N83 | EM | 3.1 Å | G/H=1-204 |
| 9N82 | EM | 3.3 Å | G/H=1-204 |
| 9CQC | EM | 3.4 Å | G/H=1-204 |
| 3WTF | X-ray | 3.45 Å | A/B=1-204 |
| 9GD7 | EM | 4.25 Å | M=1-204 |
| 8EZA | EM | 4.39 Å | S/T=1-204 |
| 8BHV | EM | 4.51 Å | c/i=1-204 |
| 8BH3 | EM | 4.55 Å | D/M=1-204 |
| 9G9L | EM | 4.63 Å | M=1-204 |
| 8BHY | EM | 5.33 Å | D/M=1-204 |
| 8EZB | EM | 8.9 Å | S/T=1-204 |
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