Bcl-2-binding component 3, isoforms 1/2 (BBC3) is a 193-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BXH1.
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The mean pLDDT of this model is 59.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 35% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity)
Interacts with MCL1 and BCL2A1 (By similarity). Interacts (via BH3 domain) with BCL2 (PubMed:11463391). Interacts with BCL2L1/BCL-XL (PubMed:23340338). Interacts (via BH3 domain) with NOL3/ARC (via CARD domain); this interaction prevents BBC3 association with BCL2 and results in CASP8 activation (By similarity)
Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5UUL | X-ray | 1.33 Å | B=132-154 |
| 4BPJ | X-ray | 1.6 Å | D=137-153 |
| 4BPK | X-ray | 1.76 Å | C/D=133-152 |
| 6TQP | X-ray | 1.85 Å | B=130-155 |
| 6QG8 | X-ray | 1.9 Å | B=127-149 |
| 4BPI | X-ray | 1.98 Å | B=134-152 |
| 6QFM | X-ray | 2.0 Å | B=127-149 |
| 7P9W | X-ray | 2.0 Å | B=130-155 |
| 7QTX | X-ray | 2.12 Å | B=130-155 |
| 7P0S | X-ray | 2.5 Å | C/U=130-155 |
| 7DVD | X-ray | 2.59 Å | E=136-150 |
| 4HNJ | X-ray | 2.9 Å | C=130-154 |
| 2M04 | NMR | B=130-154 |
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